Mosquito bypassers: infectious sporozoites grown in vitro

The whole-sporozoite-based vaccine approach has been limited by the difficulty of mass production of infectious sporozoites from infected mosquitoes. Eappen et al. describe a method for producing a large quantity of sporozoites in vitro, which opens new areas of investigations in sporozoite biology and large-scale sporozoite production for vaccine development.

Automated summary

Eappen et al. present a method for in vitro production of a large quantity of sporozoites, addressing the challenge of mass production of infectious sporozoites from infected mosquitoes. This opens up new avenues for investigating sporozoite biology and scaling up sporozoite production for vaccine development.