Transposable elements and Alzheimer's disease pathogenesis

Alzheimer's disease (AD) is charac- terized by the pathological accumu- lation of amyloid beta (A beta) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. Microglia and astrocytes respond to the ab- normal presence of tau protein with induced transposable element (TE) transcription. In this Forum, we dis- cuss new data that link dysregulated TE expression to AD pathogenesis.

Automated summary

Alzheimer's disease (AD) is characterized by the accumulation of amyloid beta (A beta) plaques and hyperphosphorylated tau, which trigger the abnormal transcription of transposable elements (TE) by microglia and astrocytes. This forum presents new data linking dysregulated TE expression to AD pathogenesis.