Gutsy sensations modulate intestinal disease

Article Biochemistry & Molecular Biology

Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection

Wen Zhang et al.

Summary: Research has found that nociceptive neurons have a significant impact on intestinal inflammation. Disrupted nociception leads to more severe inflammation and defective tissue repair processes. This disruption also causes changes in the intestinal microbiota and dysbiosis, while certain bacteria can promote tissue protection. Additionally, abnormal nociceptor gene expression was observed in intestinal biopsies from patients with inflammatory bowel diseases.

CELL (2022)

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Article Biochemistry & Molecular Biology

Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection

Daping Yang et al.

Summary: Neuroepithelial crosstalk plays a critical role in gut physiology, particularly in mediating gut barrier protection. Sensory neurons communicate with intestinal goblet cells to promote mucus secretion and gut protection via the CGRP-Ramp1 pathway. Additionally, commensal microbes can activate nociceptors to regulate CGRP release.

CELL (2022)

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Article Multidisciplinary Sciences

Non-redundant functions of group 2 innate lymphoid cells

Katja J. Jarick et al.

Summary: This article investigates the role of innate lymphoid cells (ILCs) in protective immunity. Using a mouse model specific to ILCs, researchers found that ILC2s have non-redundant functions during steady state and disease, and they interact with adaptive immune cells to organize the immune system.

NATURE (2022)

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Article Multidisciplinary Sciences

Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces

Amy M. Tsou et al.

Summary: Emerging studies have found that cooperation between neurons and immune cells plays a crucial role in regulating antimicrobial immunity, inflammation, and tissue homeostasis. Specifically, neuropeptide-mediated regulation of non-redundant functions of innate lymphoid cells (ILC2s) has been identified as an evolutionarily conserved mechanism that integrates immunity and tissue protection.

NATURE (2022)

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Article Biochemistry & Molecular Biology