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Review
Multidisciplinary Sciences
Qian Zhang et al.
Summary: SARS-CoV-2 infection is generally mild, but in around 10% of cases, it can lead to severe pneumonia and potentially death. Genetic factors, such as inborn errors of type I interferons, and pre-existing auto-antibodies can increase the risk of critical illness. The production of type I interferons is essential for host defense against the virus.
Article
Multidisciplinary Sciences
Maria Sabater Molina et al.
Summary: This study found that several SNPs in the ACE2 gene are associated with the severity of COVID-19 in patients. Some SNPs show a protective effect, while others increase the risk of hospitalization and a more severe course of the disease. These findings suggest that genetic variations may play a significant role in the severity of COVID-19 infection.
Article
Multidisciplinary Sciences
Athanasios Kousathanas et al.
Summary: This study used whole-genome sequencing to compare the genomes of 7,491 critically ill individuals with 48,400 controls, and identified 23 independent variants associated with critical COVID-19. The research found multiple genes that are involved in interferon signaling, leukocyte differentiation, and blood-type antigen secretion to be associated with critical illness.
Article
Genetics & Heredity
Julie E. Horowitz et al.
Summary: A variant that downregulates ACE2 expression is found to reduce the risk of SARS-CoV-2 infection. Associations of previously reported risk variants are replicated, and certain variants are associated with worse outcomes in individuals infected with the virus. A genetic risk score improves the prediction of disease severity.
Editorial Material
Multidisciplinary Sciences
Gita A. Pathak et al.
Article
Multidisciplinary Sciences
Gillian S. Dite et al.
Summary: The study found that age and gender are not the main factors contributing to the risk of severe COVID-19, but rather other risk factors. By developing a model that includes single-nucleotide polymorphisms and clinical risk factors, the risk of severe COVID-19 can be more accurately predicted.
Editorial Material
Genetics & Heredity
Patrick Brest et al.
Summary: By utilizing CRISPR-based whole-genome screening, Daniloski and his colleagues have identified key cellular pathways associated with SARS-CoV-2 infectivity, potentially offering new or repurposed drugs for combating COVID-19.
TRENDS IN GENETICS
(2021)
Review
Immunology
Fei Chen et al.
Summary: COVID-19, caused by SARS-CoV-2, is significantly influenced by ACE2 variants and epigenetic factors. Understanding these factors can help explain individual differences in disease susceptibility and outcomes, as well as aid in developing effective solutions and managing future outbreaks of SARS-CoV-2.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Immunology
Mankgopo Magdeline Kgatle et al.
Summary: Severe cases of COVID-19 may be influenced by metabolic and epigenetic mechanisms, including DNA methylation and histone/chromatin alterations. These epigenetic phenomena may lead to enhanced viral replication, resulting in severe symptoms and fatalities.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Mari E. K. Niemi et al.
Summary: The genetic make-up of an individual plays a role in susceptibility and response to viral infections. A global network of researchers identified 13 significant genetic loci associated with SARS-CoV-2 infection and severe COVID-19 cases. Mendelian randomization analyses suggest a causal role for smoking and body-mass index in severe COVID-19. Collaboration among human genetics researchers has allowed for the discovery of novel host genetic factors linked to COVID-19.
Article
Immunology
Yonghong Zhang et al.
JOURNAL OF INFECTIOUS DISEASES
(2020)
Editorial Material
Genetics & Heredity
Patrick Brest et al.
TRENDS IN GENETICS
(2020)
Article
Medical Laboratory Technology
Yan-Hui Wu et al.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2017)
