Proximity labeling of endogenous protein interactions enabled by directed evolution

Enhanced ascorbate peroxidase 2 (APEX2) is a protein generated with directed evolution by Lam et al. that has transformed our understanding of subcellular entities and phenomena. The rapid kinetics of this engineered protein highlights the power of directed evolution to expand the molecular toolkit for biologists.

Automated summary

Enhanced ascorbate peroxidase 2 (APEX2), created through directed evolution by Lam et al., has revolutionized our understanding of subcellular structures and phenomena. The rapid kinetics of this engineered protein demonstrate the immense potential of directed evolution in expanding the molecular toolkit for biologists.