Transplant of organs from donors with positive SARS-CoV-2 nucleic acid testing: A report from the organ procurement and transplantation network ad hoc disease transmission advisory committee

Letter Surgery

Kidney transplantation from SARS-CoV-2-positive deceased donor

Miklos Z. Molnar et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

Article Immunology

Short-term liver transplant outcomes from SARS-CoV-2 lower respiratory tract NAT positive donors

Ricardo M. La Hoz et al.

Summary: In April 2021, the US approved a policy requiring lower respiratory SARS-CoV-2 testing for lung donors. This led to the emergence of a new population of potential donors and showed promise in increasing the pool for organ donation.

TRANSPLANT INFECTIOUS DISEASE (2022)

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Article Surgery

Quantifying excess deaths among solid organ transplant recipients in the COVID-19 era

Allan B. Massie et al.

Summary: Estimating the mortality burden of COVID-19 on solid organ transplant recipients is crucial for understanding the impact of the disease. A study found that COVID-19 likely caused over 5000 excess deaths among SOTRs, representing 1 in 75 SOTRs and a substantial proportion of all deaths among SOTRs during the study period.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Editorial Material Immunology

Solid Organ Transplantation From Donors With COVID-19 Infection

Peter Boan et al.

TRANSPLANTATION (2022)

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Letter Immunology

Early Data on Utilization and Discard of Organs From COVID-19-infected Donors: A US National Registry Analysis

Gaurav Gupta et al.

TRANSPLANTATION (2022)

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Article Immunology

Solid Organ Donation and Transplantation Activity in the Eurotransplant Area During the First Year of COVID-19

Gabriel Putzer et al.

Summary: The COVID-19 pandemic had a significant impact on organ donations and transplantations in the Eurotransplant region, with a substantial decrease in the number of donors and transplantations. Pancreas transplantation was the most affected. Despite the severity of the second wave, the decline in organ donation and transplantation was comparable to that of the first wave.

TRANSPLANTATION (2022)

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Article Immunology

Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission Through Solid Organ Transplantation and Outcomes of Coronavirus Disease 2019 Among Recent Transplant Recipients

Rebecca J. Free et al.

Summary: This study investigated the transmission risk and outcomes of SARS-CoV-2 through solid organ transplantation. The study found that transmission of SARS-CoV-2 through transplantation is uncommon and pretransplant nucleic acid amplification testing can prevent transmission. Extrapulmonary organs from SARS-CoV-2-infected donors may be safely usable.

OPEN FORUM INFECTIOUS DISEASES (2022)

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Article Surgery

Utilization and outcomes of deceased donor SARS-CoV-2-positive organs for solid organ transplantation in the United States

Jesse D. Schold et al.

Summary: The impact of the coronavirus disease-19 on the transplant population and processes of care for transplant centers and organ allocation was examined in this study. The utilization of deceased donors with positive SARS-CoV-2 tests was characterized, and transplant outcomes were evaluated. The study found a significantly lower utilization of SARS-CoV-2 donors, but no evidence of reduced recipient graft survival. Practice variations were observed over time.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Article Surgery

Organ transplantation using COVID-19-positive deceased donors

Matthew J. Bock et al.

Summary: The study suggests that COVID-19 infection in deceased solid organ transplant donors does not affect recipient survival. However, there is a lack of information regarding the selection of COVID-19-positive donors.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Article Cardiac & Cardiovascular Systems

Transplanting thoracic COVID-19 positive donors: An institutional protocol and report of the first 14 cases

Emily M. Eichenberger et al.

Summary: The article presents our institution's protocol for evaluating and transplanting thoracic organs from COVID-19 positive donors and summarizes the outcomes to date. The use of thoracic organs from COVID-19 positive donors in transplantation has shown good results, with no recipients or healthcare members acquiring COVID-19 and high survival rates.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2022)

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Article Immunology

Short-term kidney transplant outcomes from severe acute respiratory syndrome coronavirus 2 lower respiratory tract positive donors

Jorge A. Sanchez-Vivaldi et al.

Summary: This study assessed short-term allograft outcomes in patients who received kidney transplants from deceased donors with lower respiratory tract (LRT) positive nucleic acid testing (NAT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The results showed excellent short-term allograft outcomes and no clinical evidence of donor-derived COVID-19 post-transplantation, regardless of whether the recipients were vaccinated or not. This suggests that the use of SARS-CoV-2 LRT NAT positive deceased donors could be considered.

TRANSPLANT INFECTIOUS DISEASE (2022)

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Article Surgery

Ten years of donor-derived disease: A report of the disease transmission advisory committee

Daniel R. Kaul et al.

Summary: Unexpected transmission of disease from donor to recipient remains a low risk of organ transplantation, with infections being the most common form followed by malignancies and other disease processes. Most cases of donor-derived disease (DDD) show symptoms within 30 days, with bacterial infections typically recognized within 45 days. DDD can lead to graft loss or death, with higher rates associated with malignancy transmission, parasitic, and fungal diseases.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Immunology

Coronavirus Disease 2019 in Solid Organ Transplant: A Multicenter Cohort Study

Olivia S. Kates et al.

Summary: The mortality rate among SOT recipients hospitalized for COVID-19 was 20.5%, with age and underlying comorbidities being the major drivers of mortality, rather than measures related to immunosuppression intensity.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Immunology

Highly Sensitive Quantification of Plasma Severe Acute Respiratory Syndrome Coronavirus 2 RNA Sheds Light on its Potential Clinical Value

David Veyer et al.

Summary: This study analyzed 58 COVID-19 patients and found that 74.1% had SARS-CoV-2 RNAemia, which correlated with disease severity. Levels of SARS-CoV-2 RNAemia were associated with severity, suggesting that it could be a potential prognostic marker for COVID-19 patients.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Immunology

Organ recovery from deceased donors with prior COVID-19: A case series

Nikole A. Neidlinger et al.

Summary: Although limited data exist regarding organ donation from deceased donors with a history of COVID-19 infection, a case series of six deceased donors with a prior history of COVID-19 showed no transmission of SARS-CoV-2 to recipients or medical personnel. This suggests that organ donation from deceased donors who have recovered from COVID-19 should be considered, pending further research.

TRANSPLANT INFECTIOUS DISEASE (2021)

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Article Immunology

Is it Safe to Be Transplanted From Living Donors Who Recovered From COVID-19? Experience of 31 Kidney Transplants in a Multicenter Cohort Study From India

Vivek B. Kute et al.

Summary: This study demonstrated the safety and feasibility of kidney transplants from living donors who recovered from COVID-19 in India, with a 100% patient and graft survival rate.

TRANSPLANTATION (2021)

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Article Surgery

Liver transplantation performed in a SARS-CoV-2 positive hospitalized recipient using a SARS-CoV-2 infected donor

Tommaso Maria Manzia et al.

Summary: This case report describes the first successful liver transplantation using a liver procured from a SARS-CoV-2 positive donor, with the recipient clearing the infection and recovering normal liver function after the surgery. The findings suggest that the prompt use of SARS-CoV-2 infected liver donors could offer a life-saving opportunity for SARS-CoV-2 positive patients who have developed neutralizing antibodies.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Surgery

Donor to recipient transmission of SARS-CoV-2 by lung transplantation despite negative donor upper respiratory tract testing

Daniel R. Kaul et al.

Summary: This case report highlights a proven transmission of SARS-CoV-2 from a lung donor to recipient, with sequence analysis confirming the donor origin of infection in both the recipient and a healthcare worker. It emphasizes the importance of testing lower respiratory tract specimens from potential lung donors and enhancing personal protective equipment for healthcare workers involved in lung procurement and transplantation.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Letter Surgery

Screening for SARS-CoV-2 in potential deceased organ donors

Ines Ushiro-Lumb et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Letter Surgery

A call to routinely test lower respiratory tract samples for SARS-CoV-2 in lung donors

Deepali Kumar et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Immunology

Evidence of SARS-CoV-2 Infection in Cells, Tissues, and Organs and the Risk of Transmission Through Transplantation

Amaury Gaussen et al.

Summary: The emergence of SARS-CoV-2 raised concerns for transplantation programs due to the potential risk of transmission through donated organs. Initial consensus excluded COVID-19 positive patients from donation, leading to a global decrease in transplantation procedures. Studies on the transmission risk through transplantation have produced inconsistent findings, highlighting the need for standardized screening practices and systematic recipient follow-up.

TRANSPLANTATION (2021)

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Article Surgery

Liver transplantation from active COVID-19 donors: A lifesaving opportunity worth grasping?

Renato Romagnoli et al.

Summary: In specific circumstances, liver transplant from donors with active COVID-19 may be considered for recipients with SARS-CoV-2 immunity to safely expand the donor pool and minimize transmission risks.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Surgery

Early success transplanting kidneys from donors with new SARS-CoV-2 RNA positivity: A report of 10 cases

Christine E. Koval et al.

Summary: Although transplantation of solid organs from donors with active SARS-CoV-2 infection is not recommended, our study suggests that transplanting extrapulmonary organs, such as kidneys, from donors with detected SARS-CoV-2 RNA during evaluation is feasible and safe, with excellent outcomes for both patients and allografts during follow-up.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Review Immunology

Organ Donation and Transplantation During the COVID-19 Pandemic: A Summary of the Spanish Experience

Beatriz Dominguez-Gil et al.

Summary: Spain has successfully rebuilt its donation and transplantation program in the face of the COVID-19 pandemic by establishing standards, actively collecting evidence, and issuing management recommendations. The experience and lessons learned from this process can potentially benefit other countries in addressing similar challenges.

TRANSPLANTATION (2021)

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Article Surgery