Micro/nanofluidic-electrochemical biosensors for in situ tumor cell analysis

Micro/nanofluidics have been demonstrated as exciting avenues for efficient capture and in situ analysis of tumor cells, which is of great importance for early tumor diagnosis, staging and treatment monitoring. Among various analytical methods, the electrochemistry has advantages of high sensitivity, easy inte-gration, and low cost. In this review, we systematically summarize the recent advances in micro/ nanofluidic-electrochemi cal biosensors for in situ tumor cell analysis, including circulating tumor cells, biomarkers on tumor cells and biomarkers secreted by tumor cells. Perspectives associated with micro/ nanofluidic-based electrochemical in situ analysis of tumor cells are then discussed.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

This review systematically summarizes the recent advances in micro/nanofluidic-electrochemical biosensors for in situ tumor cell analysis, including circulating tumor cells, biomarkers on tumor cells, and biomarkers secreted by tumor cells. The technology offers advantages of high sensitivity, easy integration, and low cost.