Organocatalytic regio- and enantioselective vinylogous aza-Morita-Baylis-Hillman reaction

Asymmetric regioselective vinylogous aza-Morita-Baylis-Hillman reactions by organocatalysis were developed. The reactions of 3-vinylcyclopentenone with various aldimines in the presence of chiral pyrrolidinopyridine catalysts gave the 7-adducts in high regioselectivity and moderate enantioselectivity.(c) 2022 Elsevier Ltd. All rights reserved.

Automated summary

Asymmetric regioselective vinylogous aza-Morita-Baylis-Hillman reactions were conducted using organocatalysis. The reactions between 3-vinylcyclopentenone and various aldimines, in the presence of chiral pyrrolidinopyridine catalysts, yielded 7-adducts with high regioselectivity and moderate enantioselectivity.