A study of the reactivity of cyclic aminomethylammonium mannich salts

A novel method for the preparation of aminoalkylaminomethyl products was developed utilising novel Mannich-type salts featuring a R2NCH2NR3thorn moiety. This methodology showed good nucleophile scope and was successfully employed in reactions under basic, acidic, and neutral conditions. A wide range of diamine products was successfully synthesised, including a neuropeptide Y antagonist. (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Automated summary

A novel method utilizing novel Mannich-type salts was developed for the preparation of aminoalkylaminomethyl products. The method showed good nucleophile scope and was applicable to reactions under basic, acidic, and neutral conditions, successfully synthesizing a wide range of diamine products.