Chemoselective oxidation of alcohols in the presence of amines using an oxoammonium salt

The oxidation of alcohols in the presence of reactive amines employing the commercially available oxoammonium cation, Bobbitt's salt is described. The oxidation is accomplished under acidic condi-tions and subsequent treatment with a suitable base affords a convenient one-pot method to access imines in good to excellent isolated yields (74-99%).(c) 2022 Elsevier Ltd. All rights reserved.

Automated summary

The oxidation of alcohols in the presence of reactive amines using the commercially available oxoammonium cation, Bobbitt's salt, is reported. The oxidation is carried out under acidic conditions, and subsequent treatment with a suitable base provides a convenient one-pot method for the synthesis of imines with high yields (74-99%).