4.4 Article

Function of a pathway-associated major facilitator superfamily gene hsaf-orf1 in the biosynthesis of the antifungal HSAF in Lysobacter enzymogenes

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Biosynthesis, regulation, and engineering of natural products from Lysobacter

Huan Yue et al.

Summary: This article reviews the progress in Lysobacter natural product research over the past ten years, including molecular mechanisms for biosynthesis, regulation and mode of action, genome mining of cryptic biosynthetic gene clusters, and metabolic engineering using synthetic biology tools.

NATURAL PRODUCT REPORTS (2022)

Article Biotechnology & Applied Microbiology

An Antifungal Polycyclic Tetramate Macrolactam, Heat-Stable Antifungal Factor (HSAF), Is a Novel Oxidative Stress Modulator in Lysobacter enzymogenes

Lingjun Yu et al.

Summary: PoTeMs are a rapidly growing family of antibiotic natural products with iron-chelating properties that can protect DNA from oxidative damage, helping bacteria survive under oxidative stress.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2021)

Review Chemistry, Multidisciplinary

Structures and General Transport Mechanisms by the Major Facilitator Superfamily (MFS)

David Drew et al.

Summary: The major facilitator superfamily (MFS) is the largest known superfamily of secondary active transporters, responsible for transporting a wide range of substrates with remarkable diversity and complex gating mechanisms. Studies have shown that residues far from the substrate binding site in MFS transporters can be just as important, and some have evolved to form unique complexes. Through in-depth descriptions of glucose transporters and multidrug resistance antiporters, novel refinements to the rocker-switch alternating-access model have been proposed.

CHEMICAL REVIEWS (2021)

Article Biochemistry & Molecular Biology

Outer Membrane Vesicle-Mediated Codelivery of the Antifungal HSAF Metabolites and Lytic Polysaccharide Monooxygenase in the Predatory Lysobacter enzymogenes

Huan Yue et al.

Summary: Lysobacter, particularly L. enzymogenes, known for producing lytic enzymes and bioactive metabolites, utilizes a previously uncharacterized synergistic strategy involving the LeLPMO10A-encoded chitin-binding protein and antifungal compounds colocalized in outer membrane vesicles when interacting with fungal prey. This study sheds light on the predatory interaction mechanism with fungi.

ACS CHEMICAL BIOLOGY (2021)

Review Microbiology

Antifungal weapons of Lysobacter, a mighty biocontrol agent

Long Lin et al.

Summary: This article describes the antifungal mechanisms of Lysobacter and the structure, biosynthetic pathway, action mode, and applications of its weapons, with a discussion on the evolution of flagellar type III secretion system into an enzyme secretion machine for intermediate-range antifungal weapons, and the coordination between the long-range weapon HSAF and the proposed contact-dependent killing device, type VI secretion system. It also outlines the regulatory mechanisms of HSAF production involving specific transcription factors and the bacterial second messenger c-di-GMP.

ENVIRONMENTAL MICROBIOLOGY (2021)

Article Chemistry, Multidisciplinary

Biosynthesis of the Polycyclic System in the Antifungal HSAF and Analogues from Lysobacter enzymogenes

Yaoyao Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Article Biotechnology & Applied Microbiology

Vesicular Delivery of the Antifungal Antibiotics of Lysobacter enzymogenes C3

Paul R. Meers et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2018)

Review Cell Biology

Understanding transport by the major facilitator superfamily (MFS): structures pave the way

Esben M. Quistgaard et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Chemistry, Multidisciplinary

Heterologous Reconstitution of Ikarugamycin Biosynthesis in E. coli

Janine Antosch et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Article Chemistry, Multidisciplinary

Mechanistic Insights into Polycycle Formation by Reductive Cyclization in Ikarugamycin Biosynthesis

Guangtao Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Article Biochemistry & Molecular Biology

The major facilitator superfamily (MFS) revisited

Vamsee S. Reddy et al.

FEBS JOURNAL (2012)

Review Biochemistry & Molecular Biology

Bioactive natural products from Lysobacter

Yunxuan Xie et al.

NATURAL PRODUCT REPORTS (2012)

Article Chemistry, Multidisciplinary

Biosynthesis of HSAF, a Tetramic Acid-Containing Macrolactam from Lysobacter enzymogenes

Lili Lou et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Agriculture, Multidisciplinary

Identification and Characterization of Lysobacter enzymogenes as a Biological Control Agent Against Some Fungal Pathogens

Qian Guo-liang et al.

AGRICULTURAL SCIENCES IN CHINA (2009)