期刊
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
卷 61, 期 6, 页码 984-988出版社
ELSEVIER TAIWAN
DOI: 10.1016/j.tjog.2021.01.034
关键词
Chronic endometritis; CD138; Repeated implantation failure
资金
- National Key Research & Developmental Program of China [2018YFC1003900, 2018YFC1003904]
- National Natural Science Foundation of China [8160060585, 81601279]
- Sanming Project of Medicine in Shenzhen [SZSM201502035]
- Basic Research Program of Shenzhen [JCYJ20180228164631121, JCYJ20190813161203606]
Chronic endometritis (CE) may affect embryo implantation and clinical pregnancy outcomes in patients with repeated implantation failure (RIF).
Objective: To assess whether chronic endometritis (CE) affects embryo implantation in patients with repeated implantation failure (RIF). Materials and methods: We retrospectively analyzed 126 RIF patients who were never diagnosed with CE and received no prior antibiotic therapy. Endometrial specimens obtained by endometrial scratching during mid-luteal phase were immunostained by CD138, a hallmark plasmacyte marker, to identify CE. Pregnancy outcome in RIF patients who underwent IVF-ET frozen-embryo within transfers 6 months after endometrial scratching was compared between women with and without CE. Results: The prevalence of CE in patients with RIF was found to be 11.9% (15/126). Moreover, a significantly reduced clinical pregnancy rate was observed in RIF patients with CE (20% vs. 46.85%; p = 0.04). The live birth rate also exhibited a decreasing trend in RIF patients with CE, although there was no statistically significant difference (20% vs. 41.58%; p = 0.109). Conclusions: CE may be involved in the failure of embryo implantation and reduced clinical pregnancy outcome in patients with RIF. (c) 2022 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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