Synthesis of higher-membered heterocycles

Heterocycles constitute a very important class of compounds in organic chemistry. The heterocyclic frameworks represent the main structural subunits of various natural products and biologically active compounds. The formation of higher-membered heterocyclic compounds has been a center of focus for a very long time and has attracted great attention for the development of improved synthetic approaches toward milder, clean, and high yielding strategies. Several classical approaches involve carbon-heteroatom bond-forming reactions like dipolar cycloaddition for ring closure, reductive amination, or nucleophilic substitution in the synthesis of these compounds. This review article is focused on the synthesis of several higher-membered heterocyclic compounds.

Automated summary

Heterocycles are an important category of compounds in organic chemistry, which serve as the main structural subunits of various natural products and biologically active compounds. The synthesis of higher-membered heterocyclic compounds has been a subject of interest for developing improved synthetic procedures with milder conditions and higher yields. This review article specifically discusses the synthesis of higher-membered heterocyclic compounds, highlighting the classical approaches involving carbon-heteroatom bond-forming reactions.