An easy and regioselective synthesis of new functionalized isoxazoline derivatives via a 1,3-dipolar cycloaddition reaction

An efficient and original synthesis of various aminophosphonate-containing isoxazoline derivatives is reported. A library of variously substituted compounds was readily synthesized via a 1,3-dipolar cycloaddition reaction of beta-ethoxycarbonyl N-methylphosphonated allylic amines used as dipolarophiles with chloroximes under mild conditions.

Automated summary

An efficient and original method for the synthesis of aminophosphonate-containing isoxazoline derivatives is described. A library of various substituted compounds can be readily synthesized through a 1,3-dipolar cycloaddition reaction under mild conditions.