A Concise Total Synthesis of (±)-Stepharine and (±)-Pronuciferine

A concise total synthesis of (+/-)-stepharine and (+/-)-pronuciferine using readily available reagents as the starting materials is reported. This synthesis features a three-component Catellani reaction/Aucatalyzed 6-exo-dig cyclization for the assembly of 1-methylene-tetrahydroisoquinoline scaffold and an oxidative dearomatization for constructing spiro-cyclohexadienone scaffold.

Automated summary

A concise total synthesis of (+/-)-stepharine and (+/-)-pronuciferine using readily available reagents as the starting materials is reported. This synthesis features a three-component Catellani reaction/Au-catalyzed 6-exo-dig cyclization for the assembly of 1-methylene-tetrahydroisoquinoline scaffold and an oxidative dearomatization for constructing spiro-cyclohexadienone scaffold.