Time course and predictors of persistent cancer-related fatigue in long-term breast cancer survivors: a prospective observational study

Purpose The present study investigated whether the level of cancer-related fatigue (CRF) after finishing oncology treatment was related to higher levels of persistent CRF and its relationship with both functional and psychological disturbances. Second, to identify potential predictors of persistent CRF. Methods Eighty BC survivors were classified into non-fatigued (<= 3.9) or fatigued (>= 4), according to their Piper Fatigue Scale total score after finishing oncology treatment. The time course of fatigue and the impact on its domains, pain, mood state, perceived physical fitness, the level of physical activity, and quality of life were assessed at >= 5 years. Results Women classified as fatigued after finishing oncology treatment had not only a higher prevalence of persistent CRF (41.2%) at the reassessment, but also greater levels of pain (P = .006 to .048) and mood disturbances (P = .007 to .015), and lower levels of physical fitness condition (P = .002 to .039) and quality of life (P < .001 to < .05) over time. Regression analyses revealed that sadness/depression, global health status, physical activity level, and type of treatment were significant predictors of persistent CRF (r(2) = .692). Conclusion Higher levels of CRF implied greater levels of persistent CRF and a lower functional and psychological profile over time. 69.2% of of persistent CRF was explained.

Automated summary

The study examined the relationship between post-treatment cancer-related fatigue (CRF) and persistent CRF, as well as its association with functional and psychological disturbances. It also aimed to identify predictors of persistent CRF. Results showed that women classified as fatigued after treatment had higher rates of persistent CRF, along with increased pain and mood disturbances, and decreased physical fitness and quality of life.