4.7 Article

Vinyl substituted triphenylamine based turn-off fluorescent probe for selective and sensitive detection of mercury (II) in water and live cells

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2022.121887

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Mercury; Triphenylamine; Chemodosimeter; Fluorescence; Turn-off

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In this study, a vinyl substituted triphenylamine (TPA-alk) fluorescent probe was developed for the rapid and efficient detection of mercury ion (Hg2+) in water and biological environments. The probe showed selective detection of Hg2+ over a wide range of competitive metal ions and exhibited a blue shift in the UV absorbance spectrum. The detection limit was found to be 0.146 mu M (29.2 ppb) with high selectivity. The probe also showed biocompatibility and low cytotoxicity, making it suitable for cell imaging studies.
Here, we report vinyl substituted triphenylamine (TPA-alk) fluorescent probe for the rapid and efficient detection of mercury ion (Hg2+) in water and biological environment. TPA-alk detects Hg2+ selectively over a wide range of competitive metal ions with a blue shift of 43 nm in the UV absorbance spectrum. The detection limit is found to be 0.146 mu M (29.2 ppb) with high selectivity over a wide range of competitive metal ions. DFT study explains the blue shift in the UV-vis absorption band of the optical probe upon the addition of Hg2+. Cell viability assay illustrates that the probe is biocompatible and it has low cytotoxicity even at its higher concentration. Cell imaging studies demonstrate the efficiency of the TPA-alk probe for the micromolar detection of mercury (II) in live BMG1 cells.

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