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Article
Chemistry, Multidisciplinary
Xinxin Ma et al.
Summary: This study demonstrates that Prussian blue nanozyme (PBzyme) can act as a pyroptosis inhibitor to alleviate neurodegeneration in mouse and cell models of Parkinson's disease. By scavenging reactive oxygen species, inhibiting activation of the inflammasome, and reducing the production of inflammatory factors, PBzyme exerts neuroprotective effects.
ADVANCED MATERIALS
(2022)
Review
Dermatology
D. C. Bosanquet et al.
Summary: This review highlights the range of therapeutic options for difficult-to-heal wounds, emphasizing the lack of robust data for most interventions. The purpose is to provide a broad overview of interventions and summarize the evidence base for each.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Engineering, Biomedical
Kaituo Liu et al.
Summary: The VEGF hydrogel significantly accelerates wound healing and promotes collagen deposition and the formation of new blood vessels. It retains the biological activity of VEGF and has the potential to be an attractive biomaterial for clinical applications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Chemistry, Multidisciplinary
Yuan Xiong et al.
Summary: The novel HA@MnO2/FGF-2/Exos hydrogel can improve diabetic wound healing by forming a protective barrier and providing long-term antibacterial protection, while utilizing MnO2/ε-PL nanosheets to catalyze H2O2 conversion to O-2, releasing M2 Exos and FGF-2 to promote the healing process.
Article
Materials Science, Multidisciplinary
Lanjie Lei et al.
Summary: Growth factors are essential for regulating cellular responses in wound healing, and a novel multifunctional chitosan microsphere has been developed for efficient growth factor delivery and wound repair. The microspheres exhibit antibacterial properties and have been shown to significantly promote wound healing in a rat model.
MATERIALS & DESIGN
(2022)
Article
Engineering, Biomedical
Gaopeng Guan et al.
Summary: In this study, a novel angiogenic 3D-bioprinted peptide patch was developed to improve skin wound healing. The 3D-bioprinting technology allowed for the fabrication of individual patches according to the shape characteristics of the damaged tissue. These patches showed excellent biocompatibility, angiogenesis, and tissue repair both in vivo and in vitro.
MATERIALS TODAY BIO
(2022)
Article
Biochemistry & Molecular Biology
Monika Rajput et al.
Summary: Three-dimensional bioprinting based on digital light processing (DLP) provides opportunities for mimicking human tissues. However, the limited availability of biocompatible and biodegradable bioinks hinders progress in this field. This study presents a silk fibroin-derived bioink for DLP bioprinting, which exhibits bone-like viscoelastic behavior and favorable degradation. The bioink supports cell proliferation and osteogenesis. This work highlights the importance of silk fibroin-derived bioinks in tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Pharmacology & Pharmacy
Li Yang et al.
Summary: Parenteral sustained release drug formulations have been widely used in clinical practice as preferable platforms for long-term exposure therapy. However, the requirement for hypodermic injection hinders their further applications due to issues such as needle-phobia, needle-stick injuries, and inappropriate needle reuse. Microneedles offer an alternative system that is minimally invasive and allows for self-administration.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Polymer Science
Juan Liu et al.
Summary: Photocrosslinked hydrogels have significant application value in biomedical engineering due to their variety and convenient preparation methods. This paper provides a systematic review of the biomedical applications of photocrosslinked hydrogels, introduces different types of photocrosslinked hydrogel monomers, summarizes methods for their preparation, and discusses the shortcomings and potential development directions of photocrosslinked hydrogels.
Article
Materials Science, Biomaterials
Yonghang Chen et al.
Summary: Infected wound healing is a complex process that requires staged management to inhibit infection and promote wound healing. This study presents dissolving microneedles with a biphasic release of antibacterial agents and growth factors to achieve rapid inhibition of infection and slow promotion of wound healing. In vivo studies demonstrate that this biphasic release system combined with microneedles exhibits superior capability in promoting wound healing.
BIOMATERIALS SCIENCE
(2022)
Review
Materials Science, Multidisciplinary
Pooyan Makvandi et al.
Summary: This review discusses the biomimetic design, fabrication methods, and medical applications of bioinspired microneedles (BMNs), highlighting their potential in drug delivery, regenerative medicine, and other fields, as well as the future opportunities and challenges in clinical translation.
Review
Pharmacology & Pharmacy
Yunjiang Jiang et al.
Summary: AMPs and SMAMPs have attracted significant enthusiasm in the past thirty years due to their unique membrane-active antimicrobial mechanism and broad-spectrum antimicrobial activity. Despite challenges inherent to current design strategies slowing down the clinical translational development of AMPs and SMAMPs, these challenges have triggered efforts to redesign and repurpose AMPs.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Cell Biology
Haibiao Xie et al.
Summary: In this study, it was found that p53-associated enhancer RNA-p53BER2 mediates the cell cycle and senescence of p53 in TP53-WT renal cancer cells.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Hana Storkanova et al.
Summary: According to the study, plasma levels of Hsp90 are increased in patients with systemic sclerosis compared to healthy controls, and are associated with increased inflammatory activity, worsened lung function, and extent of skin involvement in patients with diffuse cutaneous systemic sclerosis. In patients with systemic sclerosis-associated interstitial lung disease treated with cyclophosphamide, baseline Hsp90 levels can predict changes in DLCO over 12 months of therapy.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Heesun Hong et al.
Summary: Chemically modified hydrogels are crucial for cell and tissue regeneration, but must be carefully evaluated for biocompatibility. The dialysis periods during chemical modification of natural polymers are essential for removing unreacted chemical residues.
Review
Chemistry, Multidisciplinary
Mayland Chang et al.
Summary: Diabetic foot ulcers (DFUs) are chronic wounds that affect 30% of diabetic patients, with dysregulation of the normal wound healing process. Infection in DFUs increases inflammation and delays wound healing. Selective inhibition of MMP-9 may be a promising strategy for treatment of DFUs.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Hui Zhang et al.
Summary: The development of controllable responsive microparticles composed of natural polymer materials, loaded with growth factors and antibacterial peptides, shows promising potential for drug release and wound healing applications. Under near-infrared (NIR) irradiation, these microparticles can achieve desired controllable release of growth factors to promote neovascularization formation. Additionally, the antibacterial peptides embedded in the microparticles provide antibacterial ability during storage and usage. These characteristics make the microparticles ideal for drug delivery and wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yuqing Liang et al.
Summary: The research developed a smart bioadhesive hydrogel sealant with self-healing and excellent antibacterial activity, showing high effectiveness in wound closure and post-wound-closure care. The hydrogel features autonomous healing, on-demand dissolution, injectability, good biocompatibility, antibacterial properties, multifunctional adhesiveness, and NIR responsiveness. In vivo evaluation demonstrated the great potential of the smart hydrogel in dealing with skin incisions and infected full-thickness skin wounds.
Review
Nanoscience & Nanotechnology
Pooyan Makvandi et al.
Summary: Transdermal microneedle patches are a promising tool for delivering active compounds into the skin, requiring sufficient skin penetration to ensure cargo release at predetermined locations. Pain signal and management during microneedle and hypodermic needle application are compared, alongside discussions on factors affecting insertion and recent strategies to improve skin penetration.
NANO-MICRO LETTERS
(2021)
Review
Cell Biology
Jordan Holl et al.
Summary: With the increasing prevalence of type 2 diabetes mellitus, the management of chronic diabetic wounds and ulcers has become a significant therapeutic challenge. Recent advancements in understanding wound healing mechanisms have led to the development of novel therapies, with a particular focus on biological dressings.
Article
Nanoscience & Nanotechnology
Huiyuan Bai et al.
Summary: Artificial Prussian blue nanozymes (PBZs) can prevent anthracycline-induced liver injury by attenuating reactive oxygen species (ROS) production and regulating inflammation. PBZs exhibit multienzyme activity, scavenging ROS and free radicals, and reducing levels of inflammatory cytokines.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Chun-Yi Chang et al.
Summary: This study presents a dynamic hydrogel system capable of simultaneously increasing stiffness and hyaluronic acid (HA) accumulation, which is crucial for mimicking the tumor microenvironment. The gelatin macromer used in this system allows for primary network crosslinking followed by bioinert or biomimetic stiffening, providing new insights into cancer cell fate processes guided by dynamically changing physicochemical matrix properties.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Multidisciplinary
Pooyan Makvandi et al.
Article
Materials Science, Biomaterials
Lanjie Lei et al.
Summary: The study identified poor vascular development as a key cause of thin endometrium and proposed inducing angiogenesis as an effective treatment strategy. By developing angiogenic hydrogel microspheres based on HAMA, the study demonstrated increased drug-loading ability, controlled drug-release rate, promotion of new blood vessel formation, and endometrial regeneration for thin endometrium treatment.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Ya Guan et al.
Summary: The study developed a sustained oxygenation system using oxygen-release microspheres and a reactive oxygen species (ROS)-scavenging hydrogel to promote diabetic wound healing. The sustained release of oxygen enhanced cell survival and migration, angiogenic growth factor expression, angiogenesis, and decreased proinflammatory cytokine expression in diabetic wounds, leading to a significant increase in wound closure rate.
Article
Materials Science, Multidisciplinary
Zhuhao Wu et al.
Summary: This study introduces a novel bioink-enabled microfluidic printing technique for rapid formation of blood vessels. By utilizing composite bioink and microfluidic printing device, vascular-like tissue structures with high viability and tunable dimensions can be fabricated efficiently.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Review
Biotechnology & Applied Microbiology
Wenqian Zhang et al.
Summary: Ulcers are a common complication of diabetes with high recurrence rates, and oxidative stress is identified as a key factor in impaired wound healing. Various antioxidant therapies have been proposed in the past 5 years to target oxidative stress and improve diabetic wound healing outcomes. These therapies include targeting Nrf2 and NF kappa B pathways, as well as utilizing vitamins, enzymes, hormones, medicinal plants, and biological materials.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Environmental
Lanjie Lei et al.
Summary: This study introduces novel multifunctional biohybrid microspheres for one-step protein separation and their application in chronic wound healing. By capturing and isolating the growth factor bFGF and combining with natural anti-inflammatory and anti-oxidative agents, these microspheres show significant promotion of angiogenesis in chronic wounds. This flexible and biohybrid microsphere system has potential for various bioactive proteins design and biomedical applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Endocrinology & Metabolism
Camilla Bean et al.
Summary: The study demonstrates that the mitochondrial cristae biogenesis protein Opa1 plays a role in cell-autonomous adipocyte browning through the regulation of the urea cycle. The findings suggest a potential therapeutic strategy for obesity and highlight the connection between the urea cycle and adipocyte browning.
Article
Medicine, Research & Experimental
Xue Xie et al.
Summary: The study found that PBzyme has potential anti-oxidative and anti-inflammatory effects in the prophylactic treatment of AP, possibly involving inhibition of signaling pathways and scavenging reactive oxygen species. This provides a foundation for the clinical application of PBzyme in the preventive treatment of AP.
Article
Medicine, Research & Experimental
Abdullah Shopit et al.
Review
Urology & Nephrology
Joanne B. Cole et al.
NATURE REVIEWS NEPHROLOGY
(2020)
Review
Chemistry, Multidisciplinary
Rezvan Jamaledin et al.
ADVANCED MATERIALS
(2020)
Review
Chemistry, Medicinal
Natallia V. Dubashynskaya et al.
Article
Engineering, Biomedical
He Zhao et al.
Review
Medical Laboratory Technology
Aaron Den Dekker et al.
TRANSLATIONAL RESEARCH
(2019)
Review
Cell & Tissue Engineering
Jolanta Gorecka et al.
STEM CELL RESEARCH & THERAPY
(2019)
Review
Engineering, Biomedical
Ziting Bao et al.
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Hyosuk Kim et al.
Article
Engineering, Biomedical
Stephan Thoenes et al.
ACTA BIOMATERIALIA
(2019)
Article
Materials Science, Multidisciplinary
Hao Chen et al.
NPG ASIA MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Zhen Lu Yang et al.
Article
Chemistry, Multidisciplinary
Maria A. Komkova et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Review
Microbiology
Laurent Poirel et al.
CLINICAL MICROBIOLOGY REVIEWS
(2017)
Article
Chemistry, Multidisciplinary
Wei Zhang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Article
Materials Science, Biomaterials
M. P. Ribeiro et al.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2013)
Review
Cell & Tissue Engineering
Clayton T. McKee et al.
TISSUE ENGINEERING PART B-REVIEWS
(2011)
Article
Multidisciplinary Sciences
KY Lee et al.
