期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 372, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2022.132626
关键词
Microneedles; Glucose detection; Interstitial skin fluid; Electrochemistry; Smart agriculturing
资金
- Singapore Ministry of Education [RG110/20, RT02/20, MOE2019-T2-2-004]
The authors developed a wire electrode embedded microneedle patch (WEMNP) for non-invasive real-time detection of glucose, which has good mechanical strength and suitable bioelectronic interface. This technology is of great significance for long-term home-based management of chronic diseases and smart agriculture.
Glucose is critical to all organisms. Herein, we developed a wire electrode embedded microneedle patch (WEMNP) for in situ real-time detection of glucose in the interstitial fluid (ISF) of skin or plant tissues with minimal invasiveness. WEMNP is made of proline treated silk fibroin proteins, which provide good mechanical strength (0.75 N/microneedle) for tissue penetration and desirable bioelectronic interface for fast and high-fidelity detection. WEMNP shows specific and linear response to glucose between 3 and 18 mM for detection in skin ISF with a sensitivity of 21.21 nA/mM and between 30 and 180 mM for detection in plant ISF with a sensitivity of 1.22 nA/mM. Such self-administrable WEMNP could be instrumental to long-term home-based management for chronic diseases and to smart agriculturing.
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