4.6 Review

Recent Advances in Electrochemical Sensors for Caffeine Determination

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Electrochemical behavior of cocaine cutting agents at the polarized liquid-liquid interface

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Rational design of platinum assimilated 3-D zinc cobalt oxide flowers for the electrochemical detection of caffeine in beverage and energy drink

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Summary: In this study, platinum nanoparticles decorated on a spinel group, zinc cobalt oxide 3-D flower were utilized for the detection of caffeine electrochemical sensor. The Pt@ZnCo2O4 modified electrode exhibited excellent electrochemical conductivity, allowing for rapid electrochemical oxidation of caffeine. The developed method showed promising results in real-time detection of caffeine in beverage samples.

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Bismuth nanoparticles decorated on Na-montmorillonite-multiwall carbon nanotube for simultaneous determination of heavy metal ions- electrochemical methods

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Cu-MOF derived CuO nanoparticle decorated amorphous carbon as an electrochemical platform for the sensing of caffeine in real samples

Veeramuthu Saravanakumar et al.

Summary: A novel electrochemical sensor based on carbonized Cu-4,4'-bipyridine-trimesic interlinked metal-organic framework (CBT-MOF) was developed for efficient determination of caffeine content in beverages. The carbonizing temperature significantly influenced the electron transfer kinetics, with an increase at 500 degrees C enhancing conductivity and above 500 degrees C resulting in decreased conductivity. The fabricated electrode material demonstrated a low detection limit, high sensitivity, and good stability, making it a promising sensor material for caffeine analysis in coffee samples.

JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS (2022)

Article Materials Science, Multidisciplinary

One-pot synthesize of graphene-ZrO2 nanocomposite: A novel modified glassy carbon electrode for the detection of caffeine in beverage samples

Merve Okutan et al.

Summary: The study successfully developed an electrochemical sensor that can rapidly and accurately detect the amount of caffeine in beverages, showing a low detection limit and good selectivity.

MATERIALS CHEMISTRY AND PHYSICS (2022)

Article Chemistry, Analytical

A modern and powerful electrochemical sensing platform for purines determination: Voltammetric determination of uric acid and caffeine in biological samples on miniaturized thick-film boron-doped diamond electrode

Olha Sarakhman et al.

Summary: In this study, a powerful electrochemical sensor was introduced for the first time for the determination of uric acid (UA) and caffeine (CAF) using a miniaturized thick-film boron-doped diamond (BDD) electrode in tandem with cyclic voltammetry (CV). The sensor showed good linear response and selectivity, with detection limits determined for both compounds. The sensor was successfully applied for the electrochemical determination of UA and CAF in human urine and plasma samples with adequate recoveries and without the need for tedious sample pretreatment procedures.

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Electrochemical determination of L-tryptophan in food samples on graphite electrode prepared from waste batteries

Zaklina Z. Tasic et al.

Summary: The research aimed to develop a cheap and non-toxic electrochemical sensor for determining a target analyte and reducing electronic waste. The sensor was prepared using a graphite rod from zinc-carbon batteries and was used to detect L-tryptophan in a Britton-Robinson buffer solution. Two electrochemical methods, differential pulse voltammetry and cyclic voltammetry, were employed in the experiment. The pH value of the support solution, scan rate, and L-tryptophan concentration were found to affect the current response. The oxidation of L-tryptophan was determined to be an irreversible two-electron/two-proton reaction controlled by a mixture of adsorption and diffusion.

SCIENTIFIC REPORTS (2022)

Article Food Science & Technology

An electrochemical sensor for caffeine at a carbon nanofiber modified glassy carbon electrode

Tsholofelo Sebokolodi et al.

Summary: This study investigates the electrochemical behavior of caffeine on an acid-activated carbon nanofiber modified glassy carbon electrode. The results show that the presence of the carbon nanofiber modifier increases the rate of the electrochemical reaction and enhances the sensitivity of caffeine detection.

JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION (2022)

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Ultra-trace detection of caffeine and theophylline with high sensitivity and selectivity using Gd2(MoO4)3 nanosheets

Gajendar Singh et al.

Summary: In this study, gadolinium molybdate (Gam) nanosheets were successfully synthesized using a hydrothermal method and showed excellent electrochemical properties for caffeine and theophylline detection. The sensor demonstrated long-term stability, recyclability, and real sample analysis, highlighting its importance in biological and pharmaceutical sample diagnosis.

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Detection of antibiotics by electrochemical sensors based on metal-organic frameworks and their derived materials

Ming Yin et al.

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MICROCHEMICAL JOURNAL (2022)

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Voltammetric detection of caffeine content in different tea stuffs by using Co3O4/GCE-Nafion electrode

Raj Kumar et al.

Summary: A study synthesized Caffeine assisted Co3O4 nanostructures for oxidation reactions, demonstrating good reproducibility and sensitivity of the modified electrode. The electrode showed excellent performance in detecting Caffeine concentration in tea samples, indicating potential application in real-sample analysis.

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY (2021)

Article Materials Science, Multidisciplinary

Separate and simultaneous determination of vanillin, theophylline and caffeine using molybdenum disulfide embedded polyaniline/graphitic carbon nitrite nanocomposite modified glassy carbon electrode

E. Murugan et al.

Summary: The modified MoS2/PANI@g-C3N4 electrode was successfully used for separate and simultaneous sensing of VAN, TP and CAF, showing high sensitivity and good selectivity under optimal experimental conditions. The electrode exhibited excellent stability and reproducibility, making it a promising material for high-performance electrochemical sensors.

DIAMOND AND RELATED MATERIALS (2021)

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Simultaneous determination of direct yellow 50, tryptophan, carbendazim, and caffeine in environmental and biological fluid samples using graphite pencil electrode modified with palladium nanoparticles

Ademar Wong et al.

Summary: The study introduced a graphite pencil electrode modified with palladium nanoparticles for the simultaneous detection of direct yellow 50, tryptophan, carbendazim, and caffeine in river water and synthetic urine samples. The device showed improved analytical performance due to the combination of the conductive surface of the graphite pencil electrode (GPE) and the enlarged surface area from palladium nanoparticles (PdNPs). The sensor, characterized by SEM and EDS, exhibited good sensitivity, repeatability, and stability with well-defined anodic peaks detected using square wave voltammetry.

TALANTA (2021)

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Applicability of Cork as Novel Modifiers to Develop Electrochemical Sensor for Caffeine Determination

Mayra K. S. Monteiro et al.

Summary: The hybrid electrochemical sensor composed of cork and graphite showed high sensitivity and reproducibility for detecting caffeine in aqueous solutions, making it suitable for analyzing samples like soft drinks and pharmaceutical formulations. The cork-graphite sensors exhibited a wider linear response range and lower limits of detection compared to traditional graphite sensors. The electrochemical determinations showed high accuracy when compared with high performance liquid chromatography measurements, suggesting the potential use of these sensors for determining caffeine in different samples.

MATERIALS (2021)

Article Biochemistry & Molecular Biology

Simultaneous Quantification of Antioxidants Paraxanthine and Caffeine in Human Saliva by Electrochemical Sensing for CYP1A2 Phenotyping

Rozalia-Maria Anastasiadi et al.

Summary: A simple, cheap, and fast electrochemical method was developed to simultaneously quantify paraxanthine and caffeine in human saliva, using differential pulse voltammetry. The method was successfully demonstrated in a small-scale trial on healthy volunteers, with results validated by ultra-high pressure liquid chromatography.

ANTIOXIDANTS (2021)

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A surface-modified silicon carbide nanoparticles based electrochemical sensor for free interferences determination of caffeine in tea and coffee

Rahman Hallaj et al.

Summary: In this study, surface-modified silicon carbide nanoparticles were used as a sensing material for the determination of caffeine, with excellent electrocatalytic activity towards caffeine oxidation demonstrated. The electrochemical behavior of the modified electrode was studied using cyclic voltammetry and the sensor's performance was evaluated through typical amperometry methods, successfully determining caffeine in commercial tea and coffee.

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A convenient strategy for the electrochemical evaluation of acetaminophen and caffeine in combined drugs and biological samples over TiO2@polymethyldopa/Pd nanocomposite functionalized glassy carbon electrodes

Shahram Lotfi et al.

Summary: A sensitive electrochemical sensor based on Pd nanoparticles adorned TiO2 nanoparticles was designed for simultaneous quantitative estimation of acetaminophen and caffeine in biological and pharmaceutical samples. The sensor showed advantages in terms of ease of preparation, stability, selectivity, repeatability, and reproducibility. Evaluation tests demonstrated negligible systematic errors between measured and real values.

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Preparation and characterization of a pencil graphite electrode modified with gold nanoparticles decorated poly (L-methionine) and its use in the simultaneous sensitive electrochemical analysis of ascorbic acid, acetaminophen, chlorpheniramine maleate, and caffeine

Dilek Eskikoy Bayraktepe et al.

Summary: This study outlines the use of an electrochemical sensor for the simultaneous analysis of active drug substances with high sensitivity and accuracy. The sensor, based on a modified pencil graphite electrode with gold nanoparticles-decorated poly(L-methionine), showed improved electrocatalytic activity for the oxidation of the drug substances. The method successfully quantified the substances in pharmaceutical dosages and serum samples, with results comparable to those obtained by the HPLC method.

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Highly sensitive direct simultaneous determination of zinc(II), cadmium(II), lead(II), and copper(II) based on in-situ-bismuth and mercury thin-film plated screen-printed carbon electrode

Ceren Yildiz et al.

Summary: Thin-film disposable screen-printed electrodes modified in situ with bismuth and mercury coatings were prepared to enhance the sensitivities and limits of detection of heavy metal ions. The Bi/Hg film electrode exhibited good analytical performance with low detection limits, excellent repeatability, and reasonable interferences by various inorganic species.

MONATSHEFTE FUR CHEMIE (2021)

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Electrochemical sensing platform based on covalent organic framework materials and gold nanoparticles for high sensitivity determination of theophylline and caffeine

Qixia Guan et al.

Summary: A novel covalent organic framework was prepared and utilized to fabricate an electrochemical sensing platform with high performance for sensitive and selective detection of theophylline and caffeine simultaneously. The platform showed low detection limits, wide linear ranges, and successful application in real sample analyses.

MICROCHIMICA ACTA (2021)

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Determination of Ascorbic Acid, Acetaminophen, and Caffeine in Urine, Blood Serum by Electrochemical Sensor Based on ZnO-Zn2SnO4-SnO2 Nanocomposite and Graphene

Elham Nikpanje et al.

Summary: In this study, a simple electrochemical sensor based on a carbon paste electrode modified with ZnO-Zn2SnO4-SnO2 and graphene was developed for the direct, simultaneous, and individual measurement of Acetaminophen, Caffeine, and Ascorbic acid. The sensor exhibited excellent selectivity, stability, and repeatability, with recoveries ranging between 95.8% and 104.06% in urine and blood serum samples.

JOURNAL OF ELECTROCHEMICAL SCIENCE AND TECHNOLOGY (2021)

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Review of applied surface modifications of pencil graphite electrodes for paracetamol sensing

Zaklina Z. Tasic et al.

Summary: Electrochemical methods offer advantages for analysis and detection of chemical compounds, with pencil graphite electrodes proving to be an efficient and cost-effective material for detecting low concentrations of pharmaceutical compounds like paracetamol around 10(-9) M.

RESULTS IN PHYSICS (2021)

Article Chemistry, Analytical

Gold-Platinum Core-Shell Nanoparticles with Thiolated Polyaniline and Multi-Walled Carbon Nanotubes for the Simultaneous Voltammetric Determination of Six Drug Molecules

Shaopei Li et al.

Summary: A novel nanocomposite was synthesized for voltammetric determination of over-the-counter drug molecules, showing linear calibration plots and good detection limits. The nanocomposite-modified sensor exhibited good recovery yields in the detection of redox-active compounds in commercially available products.

CHEMOSENSORS (2021)

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Simultaneous Determination of Theophylline and Caffeine Using Poly(L-phenylalanine)-Reduced Graphene Oxide Modified Glassy Carbon Electrode

Lin Zhang et al.

Summary: The study successfully fabricated a poly(L-phenylalanine)-reduced graphene oxide composite film and applied it for simultaneous determination of the concentrations of theophylline and caffeine, demonstrating excellent performance. The presented method can accurately determine the target substances in a wide linear range and has good sensitivity and stability.

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Interference-free Detection of Caffeine in Complex Matrices Using a Nanochannel Electrode Modified with Binary Hydrophilic-Hydrophobic PDMS

Yintao Li et al.

Summary: A novel electrochemical sensor was developed in this study for the direct detection of caffeine in real food samples, without the need for sample pretreatment, showing excellent anti-interference and antifouling capabilities. The sensor has a wide linear range, low detection limit, and good repeatability and stability.

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Polyaniline Nanowire Arrays Deposited on Porous Carbon Derived from Raffia for Electrochemical Detection of Imidacloprid

Lei Liu et al.

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ELECTROANALYSIS (2021)

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Electrochemical Sensor for Caffeine in Coffee and Beverages Using a Naphthalene Sulfonic Acid Polymer Film-Based Modified Electrode

Alemnew Geto et al.

Summary: A polymer film-modified electrode was developed for the determination of caffeine, demonstrating electrocatalytic effects in reducing the potential needed for caffeine oxidation and increasing the current response signal. The performance of the electrode showed excellent repeatability, reproducibility, and operational stability, successfully analyzing caffeine content in instant coffee and commercial beverages.

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Molybdenum trioxide embedded graphitic carbon nitride sheets modified electrode for caffeine sensing in green tea and coffee powder

Gopal Boopathy et al.

Summary: The study explored the development of a screen-printed electrochemical sensor based on MoO3@GCNS nanocomposite for highly sensitive and selective detection of caffeine. Results showed enhanced electrocatalytic oxidation of caffeine with improved oxidation current and reduced potential. The modified electrode exhibited remarkable selectivity and sensitivity for caffeine detection in green tea and coffee powder samples.

MATERIALS CHEMISTRY AND PHYSICS (2021)

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An electrochemical sensor for nanomolar detection of caffeine based on nicotinic acid hydrazide anchored on graphene oxide (NAHGO)

Jemini Jose et al.

Summary: A simple modified sensor was developed by anchoring nicotinic acid hydrazide on graphene oxide using ultrasonic-assisted chemical route. The detailed structural and morphological analysis of NAHGO revealed its efficient electrochemical behavior for the detection of caffeine. The NAHGO sensor exhibited high sensitivity and accuracy in detecting caffeine, making it a promising analytical tool for caffeine determination.

SCIENTIFIC REPORTS (2021)

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Graphene-supported nanomaterials as electrochemical sensors: A mini review

H. C. Ananda Murthy et al.

Summary: Graphene serves as a prominent base material for supporting various inorganic and organic materials in scientific research and innovation, enabling the preparation of electrochemical sensors for detecting different electroactive species. Various characterization techniques have been successfully applied to explore the properties of graphene supported nanomaterials, showing high sensitivity and stability in sensor applications.

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Facile Fabrication of Graphene-Supported Pt Electrochemical Sensor for Determination of Caffeine

Jie Qiao et al.

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Thiol functionalized carbon ceramic electrode modified with multi-walled carbon nanotubes and gold nanoparticles for simultaneous determination of purine derivatives

Celia Ferrag et al.

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Simultaneous Detection of Paracetamol, Ascorbic Acid, and Caffeine Using a Bismuth-silver Nanosensor

Charlton van der Horst et al.

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Antonella Curulli

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B. M. Santhosh et al.

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Novel cork-graphite electrochemical sensor for voltammetric determination of caffeine

Mayra K. S. Monteiro et al.

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Graphene Oxide: A Smart (Starting) Material for Natural Methylxanthines Adsorption and Detection

Rita Petrucci et al.

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Microwave synthesis and voltammetric simultaneous determination of paracetamol and caffeine using an MOF-199-based electrode

Tran Thanh Minh et al.

JOURNAL OF MATERIALS SCIENCE (2018)

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The Fabrication of in Situ Triton X-100 on Multi-Walled Carbon Nanotubes Modified Gold Electrode for Sensitive Determination of Caffeine

Kanit Mukdasai et al.

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One-pot Synthesis of Fe2O3/PEDOT/rGO Nanocomposite for Sensitive Determination of Caffeine

Lei Gao et al.

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE (2018)

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Applicability of activated carbon obtained from peach stone as an electrochemical sensor for detecting caffeine

J. J. Arroyo-Gomez et al.

JOURNAL OF ELECTROANALYTICAL CHEMISTRY (2018)

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Electrochemical Determination of Caffeine in Tea Using a Polydopamine-Gold Nanocomposite

Guolin Zhang et al.

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE (2017)

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Electrochemical Determination of Caffeine in Oolong Tea Based on Polyelectrolyte Functionalized Multi-Walled Carbon Nanotube

Yan Zhang et al.

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Zinc Oxide Nanoparticle-modified Glassy Carbon Electrode as a Highly Sensitive Electrochemical Sensor for the Detection of Caffeine

Ramu Jagadish et al.

JOURNAL OF THE CHINESE CHEMICAL SOCIETY (2017)

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Green Electrochemical Sensor for Caffeine Determination in Environmental Water Samples: The Bismuth Film Screen-Printed Carbon Electrode

Katarzyna Tyszczuk-Rotko et al.

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Synthesis of poly(8-aminopyrene-1,3,6-trisulfonic acid)/CNT Nanocomposite for Electrochemical Detection of Caffeine

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Electrochemical determination of aspirin and caffeine at MWCNTs-poly-4-vinylpyridine composite modified electrode

Hanieh Ghadimi et al.

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Heba M. Mohamed

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Fereshteh Chekin et al.

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MnFe2O4@CNT-N as novel electrochemical nanosensor for determination of caffeine, acetaminophen and ascorbic acid

Diana M. Fernandes et al.

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Caffeine in surface and wastewaters in Barbados, West Indies

Quincy A. Edwards et al.

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