☆ 4.6 Article

Extracellular vesicles for precision medicine in prostate cancer-Is it ready for clinical translation?

SEMINARS IN CANCER BIOLOGY (2023)

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Changes in phospholipid metabolism in exosomes of hormone-sensitive and hormone-resistant prostate cancer cells

Xianlin Yi et al.

Summary: The study reveals differences in lipid metabolism in exosomes of hormone-sensitive and hormone-resistant prostate cancer cells, indicating potential for lipid-based biomarker screening. Phospholipids show varying compositions in exosomes from different cells, highlighting the importance of phosphatidylcholine and lysophosphatidylcholine in hormone-sensitive prostate cancer. Targeting lysophosphatidylcholine, autophagy, and ferroptosis pathways may offer new therapeutic strategies. The modified PEG precipitation technique shows promise for isolating prostate cancer cell exosomes for cancer screening.

JOURNAL OF CANCER (2021)

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Article Medicine, Research & Experimental

Discovery of extracellular vesicles derived miR-181a-5p in patient's serum as an indicator for bone-metastatic prostate cancer

Yanqing Wang et al.

Summary: The study identified miR-181a-5p as a potential diagnostic biomarker for bone-metastatic prostate cancer in EVs from patient's serum, with significantly upregulated expression in bone metastatic groups compared to non-bone metastatic groups. Logistic regression and AUC analysis confirmed miR-181a-5p as the best biomarker for diagnosing both prostate cancer and bone metastatic prostate cancer.

THERANOSTICS (2021)

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Article Pharmacology & Pharmacy

Preserving extracellular vesicles for biomedical applications: consideration of storage stability before and after isolation

Fumin Yuan et al.

Summary: Extracellular vesicles (EVs) are nanovesicles released by various cell types, known for their potent biological activities. While -80 degrees C is considered as the most favorable condition for storage, challenges remain in understanding the impact of storage conditions on EVs, indicating further research is needed.

DRUG DELIVERY (2021)

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Review Urology & Nephrology

Use of gallium-68 prostate-specific membrane antigen positron-emission tomography for detecting lymph node metastases in primary and recurrent prostate cancer and location of recurrence after radical prostatectomy: an overview of the current literature

Henk B. Luiting et al.

BJU INTERNATIONAL (2020)

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Article Biochemistry & Molecular Biology

The role of actinin-4 (ACTN4) in exosomes as a potential novel therapeutic target in castration-resistant prostate cancer

Yu Ishizuya et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Pathology

Polymer-Based Precipitation of Extracellular Vesicular miRNAs from Serum Improve Gastric Cancer miRNA Biomarker Performance

Ka Yan Chung et al.

JOURNAL OF MOLECULAR DIAGNOSTICS (2020)

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Article Chemistry, Multidisciplinary

Enabling Sensitive Phenotypic Profiling of Cancer-Derived Small Extracellular Vesicles Using Surface-Enhanced Raman Spectroscopy Nanotags

Wei Zhang et al.

ACS SENSORS (2020)

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Article Multidisciplinary Sciences

A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum

K. Brennan et al.

SCIENTIFIC REPORTS (2020)

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Article Chemistry, Analytical

EV-Ident: Identifying Tumor-Specific Extracellular Vesicles by Size Fractionation and Single-Vesicle Analysis

Dongyoung Kim et al.

ANALYTICAL CHEMISTRY (2020)

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Article Urology & Nephrology

Combined Cell-free DNA and RNA Profiling of the Androgen Receptor: Clinical Utility of a Novel Multianalyte Liquid Biopsy Assay for Metastatic Prostate Cancer

Heidi Fettke et al.

EUROPEAN UROLOGY (2020)

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Article Urology & Nephrology

Urine Extracellular Vesicle GATA2 mRNA Discriminates Biopsy Result in Men with Suspicion of Prostate Cancer

J. Woo et al.

JOURNAL OF UROLOGY (2020)

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Article Urology & Nephrology

Expression of Small Noncoding RNAs in Urinary Exosomes Classifies Prostate Cancer into Indolent and Aggressive Disease

Wei-Lin Winnie Wang et al.

JOURNAL OF UROLOGY (2020)

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Article Biochemistry & Molecular Biology

When Less Is More: Specific Capture and Analysis of Tumor Exosomes in Plasma Increases the Sensitivity of Liquid Biopsy for Comprehensive Detection of Multiple Androgen Receptor Phenotypes in Advanced Prostate Cancer Patients

Chiara Foroni et al.

BIOMEDICINES (2020)

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Article Chemistry, Analytical

Automated On-Line Isolation and Fractionation System for Nanosized Biomacromolecules from Human Plasma

Evgen Multia et al.

ANALYTICAL CHEMISTRY (2020)

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Review Biochemistry & Molecular Biology

Exosome Composition and Seminal Plasma Proteome: A Promising Source of Biomarkers of Male Infertility

Luz Candenas et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option?

Karim Sidhom et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

MicroRNA determinants of neuroendocrine differentiation in metastatic castration-resistant prostate cancer

Divya Bhagirath et al.

ONCOGENE (2020)

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Article Multidisciplinary Sciences

Extracellular vesicles from human plasma and serum are carriers of extravesicular cargo-Implications for biomarker discovery

Mari Palviainen et al.

PLOS ONE (2020)

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Article Medicine, General & Internal

Fifteen year quality of life outcomes in men with localised prostate cancer: population based Australian prospective study

Carolyn G. Mazariego et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Article Oncology

Loss of exosomal miR-146a-5p from cancer-associated fibroblasts after androgen deprivation therapy contributes to prostate cancer metastasis

Yu Zhang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Immunocapture-based ELISA to characterize and quantify exosomes in both cell culture supernatants and body fluids

Mariantonia Logozzi et al.

EXTRACELLULAR VESICLES (2020)

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Article Biochemical Research Methods

Microfluidic Raman biochip detection of exosomes: a promising tool for prostate cancer diagnosis

Yanlin Wang et al.

LAB ON A CHIP (2020)

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Article Oncology

Accelerating precision medicine in metastatic prostate cancer

Joaquin Mateo et al.

NATURE CANCER (2020)

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Article Materials Science, Biomaterials

Single Extracellular Vesicle Protein Analysis Using Immuno-Droplet Digital Polymerase Chain Reaction Amplification

Jina Ko et al.

ADVANCED BIOSYSTEMS (2020)

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Article Oncology

Detection of Prostate Cancer Antigen 3 and Prostate Cancer Susceptibility Candidate in Non-DRE Urine Improves Diagnosis of Prostate Cancer in Chinese Population

Lie-Fu Ye et al.

PROSTATE CANCER (2020)

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Review Medicine, Research & Experimental

Extracellular vesicles: the next generation of biomarkers for liquid biopsy-based prostate cancer diagnosis

Bairen Pang et al.

THERANOSTICS (2020)

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Article Urology & Nephrology

A 16-yr Follow-up of the European Randomized study of Screening for Prostate Cancer

Jonas Hugosson et al.

EUROPEAN UROLOGY (2019)

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Article Biochemical Research Methods

Asymmetric-flow field-flow fractionation technology for exomere and small extracellular vesicle separation and characterization

Haiying Zhang et al.

NATURE PROTOCOLS (2019)

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News Item Medicine, General & Internal

Cancer survival data emphasise importance of early diagnosis

Nigel Hawkes

BMJ-BRITISH MEDICAL JOURNAL (2019)

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Article Biochemistry & Molecular Biology

Exosome-derived miR-27a produced by PSC-27 cells contributes to prostate cancer chemoresistance through p53

Zhigang Cao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Cell Biology

Transfer of Functional Cargo in Exomeres

Qin Zhang et al.

CELL REPORTS (2019)

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Article Endocrinology & Metabolism

Plasma extracellular vesicles as phenotypic biomarkers in prostate cancer patients

France-Helene Joncas et al.

PROSTATE (2019)

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Article Oncology

Increased Plasmatic Levels of PSA-Expressing Exosomes Distinguish Prostate Cancer Patients from Benign Prostatic Hyperplasia: A Prospective Study

Mariantonia Logozzi et al.

CANCERS (2019)

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Article Chemistry, Analytical

Expression pattern of androgen receptors, AR-V7 and AR-567es, in circulating tumor cells and paired plasma-derived extracellular vesicles in metastatic castration resistant prostate cancer

Areti Strati et al.

ANALYST (2019)

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Review Biochemistry & Molecular Biology

Mass spectrometry-based proteome profiling of extracellular vesicles and their roles in cancer biology

Raju Bandu et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

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Article Biochemical Research Methods

Urine-based liquid biopsy: non-invasive and sensitive AR-V7 detection in urinary EVs from patients with prostate cancer

Hyun-Kyung Woo et al.

LAB ON A CHIP (2019)

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Article Cell Biology

Precipitation-based extracellular vesicle isolation from rat plasma co-precipitate vesicle-free microRNAs

Jenni Karttunen et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

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Review Oncology

Epidemiology of Prostate Cancer

Prashanth Rawla

WORLD JOURNAL OF ONCOLOGY (2019)

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Article Chemistry, Multidisciplinary

Multiplexed Profiling of Single Extracellular Vesicles

Kyungheon Lee et al.

ACS NANO (2018)

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Article Oncology

microRNA-1246 Is an Exosomal Biomarker for Aggressive Prostate Cancer

Divya Bhagirath et al.

CANCER RESEARCH (2018)

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Article Health Care Sciences & Services

A multidisciplinary team-oriented intervention to increase guideline recommended care for high-risk prostate cancer: A stepped-wedge cluster randomised implementation trial

Bernadette Brown et al.

IMPLEMENTATION SCIENCE (2018)

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Article Nanoscience & Nanotechnology

Nano-Vesicles are a Potential Tool to Monitor Therapeutic Efficacy of Carbon Ion Radiotherapy in Prostate Cancer

Qi Yu et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2018)

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Article Oncology

[177Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study

Michael S. Hofman et al.

LANCET ONCOLOGY (2018)

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Article Oncology

Exosomal ephrinA2 derived from serum as a potential biomarker for prostate cancer

Shibao Li et al.

JOURNAL OF CANCER (2018)

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Review Oncology

Extracellular Vesicles in Prostate Cancer Carcinogenesis, Diagnosis, and Management

Virginie Vlaeminck-Guillem

FRONTIERS IN ONCOLOGY (2018)

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Article Urology & Nephrology

Prospective Adaptive Utility Trial to Validate Performance of a Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer in Patients with Prostate-specific Antigen 2-10 ng/ml at Initial Biopsy

James McKiernan et al.

EUROPEAN UROLOGY (2018)

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Review Medicine, General & Internal

Prostate cancer screening with prostate-specific antigen (PSA) test: a systematic review and meta-analysis

Dragan Ilic et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

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Article Optics

On-chip optical trapping of extracellular vesicles using box-shaped composite SiO2-Si3N4 waveguides

Gyllion Brian Loozen et al.

OPTICS EXPRESS (2018)

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Article Cell Biology

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Cell Biology

Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression

Marc Clos-Garcia et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Cell Biology

Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma

Tatyana Vagner et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Review Urology & Nephrology

Biochemical recurrence after radical prostatectomy: what does it mean?

Rafael Tourinho-Barbosa et al.

INTERNATIONAL BRAZ J UROL (2018)

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Review Biochemistry & Molecular Biology

Current knowledge on exosome biogenesis and release

Nina Pettersen Hessvik et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

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Article Oncology

Targeted proteomics in urinary extracellular vesicles identifies biomarkers for diagnosis and prognosis of prostate cancer

Tamara Sequeiros et al.

ONCOTARGET (2017)

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Article Biophysics

Atomic force microscopy analysis of extracellular vesicles

P. Parisse et al.

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2017)

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Article Oncology

Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers

Tore Skotland et al.

EUROPEAN JOURNAL OF CANCER (2017)

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Article Urology & Nephrology

The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients

Marzia Del Re et al.

EUROPEAN UROLOGY (2017)

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Review Medicine, General & Internal

The Diagnosis and Treatment of Prostate Cancer A Review

Mark S. Litwin et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

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Article Oncology

Randomized, Noncomparative, Phase II Trial of Early Switch From Docetaxel to Cabazitaxel or Vice Versa, With Integrated Biomarker Analysis, in Men With Chemotherapy-Naive, Metastatic, Castration-Resistant Prostate Cancer

Emmanuel S. Antonarakis et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

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Article Biochemistry & Molecular Biology

Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes

Marta Rodriguez et al.

MOLECULAR CANCER (2017)

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Article Endocrinology & Metabolism

MiR-145 detection in urinary extracellular vesicles increase diagnostic efficiency of prostate cancer based on hydrostatic filtration dialysis method

Yong Xu et al.

PROSTATE (2017)

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Article Endocrinology & Metabolism

Detection of prostate cancer-specific transcripts in extracellular vesicles isolated from post-DRE urine

Kathryn L. Pellegrini et al.

PROSTATE (2017)

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Article Oncology

Multiplexed targeted mass spectrometry assays for prostate cancer-associated urinary proteins

Tujin Shi et al.

ONCOTARGET (2017)

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Article Medicine, Research & Experimental

Metabolomic Profiling of Extracellular Vesicles and Alternative Normalization Methods Reveal Enriched Metabolites and Strategies to Study Prostate Cancer-Related Changes

Maija Puhka et al.

THERANOSTICS (2017)

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Review Oncology

Prognostic and predictive biomarkers in prostate cancer: latest evidence and clinical implications

Naoki Terada et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2017)

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Article Multidisciplinary Sciences

Racial differences in the expression of inhibitors of apoptosis (IAP) proteins in extracellular vesicles (EV) from prostate cancer patients

Salma Khan et al.

PLOS ONE (2017)

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Article Multidisciplinary Sciences

Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer

Kazutoshi Fujita et al.

SCIENTIFIC REPORTS (2017)

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Review Pharmacology & Pharmacy

Tissue-based biomarkers in prostate cancer

Timothy N. Clinton et al.

EXPERT REVIEW OF PRECISION MEDICINE AND DRUG DEVELOPMENT (2017)

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Article Oncology

Detection of circulating miRNAs: comparative analysis of extracellular vesicle-incorporated miRNAs and cell-free miRNAs in whole plasma of prostate cancer patients

Edgars Endzelins et al.

BMC CANCER (2017)

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Article Oncology

Increased PSA expression on prostate cancer exosomes in in vitro condition and in cancer patients

Mariantonia Logozzi et al.

CANCER LETTERS (2017)

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Review Cardiac & Cardiovascular Systems

Methodological Guidelines to Study Extracellular Vesicles

Frank A. W. Coumans et al.

CIRCULATION RESEARCH (2017)

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Article Chemistry, Analytical

Size Dependent Lipidomic Analysis of Urinary Exosomes from Patients with Prostate Cancer by Flow Field-Flow Fractionation and Nanoflow Liquid Chromatography-Tandem Mass Spectrometry

Joon Seon Yang et al.

ANALYTICAL CHEMISTRY (2017)

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Review Oncology

Deciphering the function of non-coding RNAs in prostate cancer

Joao Ramalho-Carvalho et al.

CANCER AND METASTASIS REVIEWS (2016)

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Article Urology & Nephrology

Urine TMPRSS2:ERG Plus PCA3 for Individualized Prostate Cancer Risk Assessment

Scott A. Tomlins et al.

EUROPEAN UROLOGY (2016)

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Review Biochemical Research Methods

Current state of the art for enhancing urine biomarker discovery

Michael Harpole et al.

EXPERT REVIEW OF PROTEOMICS (2016)

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Article Chemistry, Multidisciplinary

Acoustic Purification of Extracellular Microvesicles

Kyungheon Lee et al.

ACS NANO (2015)

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Review Oncology

Androgen deprivation of prostate cancer: Leading to a therapeutic dead end

Arndt Katzenwadel et al.

CANCER LETTERS (2015)

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Article Multidisciplinary Sciences

Tumour exosome integrins determine organotropic metastasis

Ayuko Hoshino et al.

NATURE (2015)

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Article Oncology

A molecular signature of PCA3 and ERG exosomal RNA from non-DRE urine is predictive of initial prostate biopsy result

M. J. Donovan et al.

PROSTATE CANCER AND PROSTATIC DISEASES (2015)

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Article Oncology

Serum exosomal P-glycoprotein is a potential marker to diagnose docetaxel resistance and select a taxoid for patients with prostate cancer

Taku Kato et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2015)

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Article Oncology

Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel

Pedram Kharaziha et al.

ONCOTARGET (2015)

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Article Cell Biology

High-speed centrifugation induces aggregation of extracellular vesicles

Romain Linares et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Review Urology & Nephrology

Early Salvage Radiotherapy Following Radical Prostatectomy

David Pfister et al.

EUROPEAN UROLOGY (2014)

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Article Cell Biology

Co-isolation of extracellular vesicles and high-density lipoproteins using density gradient ultracentrifugation

Yuana Yuana et al.

JOURNAL OF EXTRACELLULAR VESICLES (2014)

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Article Oncology

A randomised trial of robotic and open prostatectomy in men with localised prostate cancer

Robert A. Gardiner et al.

BMC CANCER (2012)

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Article Multidisciplinary Sciences

Docetaxel-Resistance in Prostate Cancer: Evaluating Associated Phenotypic Changes and Potential for Resistance Transfer via Exosomes

Claire Corcoran et al.

PLOS ONE (2012)

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Review Pathology

Progensa™ PCA3 test for prostate cancer

Xavier Durand et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2011)

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Article Genetics & Heredity

The effects of male aging on semen quality, sperm DNA fragmentation and chromosomal abnormalities in an infertile population

Sonia Brahem et al.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2011)

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Article Chemistry, Medicinal

4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1

Keith A. Menear et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

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Article Multidisciplinary Sciences

A Tissue Biomarker Panel Predicting Systemic Progression after PSA Recurrence Post-Definitive Prostate Cancer Therapy

Tohru Nakagawa et al.

PLOS ONE (2008)

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Article Oncology

The phoenix definition of biochemical failure predicts for overall survival in patients with prostate cancer

Matthew C. Abramowitz et al.

CANCER (2008)

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Article Medicine, General & Internal

Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer

Lionel L. Banez et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2007)

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Article Oncology

Defining biochemical recurrence of prostate cancer after radical prostatectomy: A proposal for standardized definition

Andrew J. Stephenson et al.

JOURNAL OF CLINICAL ONCOLOGY (2006)

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