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Article
Environmental Sciences
Aikaterini Galani et al.
Summary: This study in Greece measured the SARS-CoV-2 RNA load in raw wastewater as an early indicator of COVID-19 cases, hospitalizations, and ICU admissions, showing predictive leads of 5 to 9 days. Modeling techniques were used to establish relationships between RNA load in wastewater and pandemic health indicators, demonstrating the potential of combining clinical and environmental surveillance data to study and predict COVID-19 dynamics.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Van Vo et al.
Summary: Monitoring wastewater from dormitories can effectively identify viral genomes, benefiting COVID-19 wastewater surveillance programs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Environmental Sciences
Warish Ahmed et al.
Summary: Monitoring pathogens like SARS-CoV-2 in wastewater using RT-PCR is effective for public health information, but there is a lack of standardized protocols for wastewater surveillance. Key strategies for improving accuracy include QA/QC measures, representative sampling, virus concentration, and clear data interpretation guidelines.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Davida S. Smyth et al.
Summary: Tracking the genetic diversity of SARS-CoV-2 is important to monitor the emergence of novel variants resistant to immunity. The researchers detected increasing frequencies of novel cryptic SARS-CoV-2 lineages in the New York City wastewater, containing mutations rarely observed in clinical samples. These lineages share mutations with the Omicron variant and have expanded tropism and resistance to neutralizing antibodies.
NATURE COMMUNICATIONS
(2022)
Article
Public, Environmental & Occupational Health
Amy E. Kirby et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2022)
Review
Biotechnology & Applied Microbiology
Jose Alhama et al.
Summary: Wastewater-Based Epidemiology (WBE) is widely used for monitoring the progression of the current SARS-CoV-2 pandemic at local levels, but attention should be paid to limitations in methods related to sampling, concentrating viruses, and quantification; Factors influencing SARS-CoV-2 monitoring in wastewater include temperature, sampling methods and schedules, virus concentration methods, and detection methods; Developing common standardized protocols is essential for alerting authorities to implement early action measures.
MICROBIAL BIOTECHNOLOGY
(2022)
Review
Medicine, General & Internal
Shi-Yan Ren et al.
Summary: This review summarizes the highly mutated regions, infectivity, transmission, vaccine breakthrough, and antibody resistance of the SARS-CoV-2 variant Omicron. Omicron is highly transmissible and may cause milder symptoms. Vaccines are less effective against the Omicron variant.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Microbiology
Shelesh Agrawal et al.
Summary: Wastewater-based surveillance at Frankfurt Airport using genome sequencing detected the presence of Omicron variant before the first confirmed clinical report from a passenger in November 2021.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2022)
Article
Virology
Itay Bar-Or et al.
Summary: This report describes a national-scale monitoring of SARS-CoV-2 variant dynamics in Israel using wastewater sampling. The study found a complete shift in variant circulation, with B.1.1.7 replacing A19 between December 2020 and March 2021. The normalized viral load and new cases per week decreased in most test points in parallel with the national vaccination campaign.
Article
Environmental Sciences
G. La Rosa et al.
Summary: This study developed a real-time RT-PCR assay for detecting the Omicron variant of SARS-CoV-2 and found that the variant spread rapidly based on the analysis of sewage samples collected in Italy. The study confirmed the effectiveness of sewage monitoring in tracking the spread of the virus.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Femi F. Oloye et al.
Summary: Monitoring the communal incidence of COVID-19 is important for decision-making, but relying on a single method may lead to inaccurate results. Wastewater surveillance provides unbiased data that can predict COVID-19 situations in smaller communities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Letter
Immunology
Lasse D. Rasmussen et al.
Summary: We conducted wastewater surveillance for SARS-CoV-2 variants of concern using mutation-specific, real-time PCR and rapid nanopore sequencing. This surveillance can be useful for early warning of emerging variants, even in areas with low virus incidences.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Environmental Sciences
Karin Yaniv et al.
Summary: Less than a year after the outbreak of the SARS-CoV-2 virus, variants of concern like Alpha (B.1.1.7, the British variant) and Beta (B.1.351, the South Africa variant) have emerged, prompting the development of improved primers-probe sets for rapid and cost-effective detection of these variants. These new primer-probe sets have been successfully utilized in wastewater samples to detect and quantify new variants before official medical testing reports, enabling better pandemic containment responses.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Leo Heijnen et al.
Summary: Wastewater surveillance using RT-ddPCR for specific detection of the N501Y mutation in SARS-CoV-2 variants has proven to be an effective tool in monitoring the trends and spread of COVID-19 variants in the community, supporting public health decision-making for control measures.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Aikaterini Galani et al.
Summary: The study investigated the concentration changes of various pharmaceuticals in wastewater in Athens, Greece during 2019 and 2020, revealing that antiviral drugs, hydroxychloroquine, and antibiotics were the most commonly used treatments against COVID-19 in Greece during the first wave of the pandemic. Meanwhile, NSAIDs showed a decrease in usage, while paracetamol saw a significant increase in usage.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Margaritis Avgeris et al.
Summary: Wastewater-based epidemiology (WBE) has emerged as a cost-effective method for real-time population-wide monitoring of SARS-CoV-2 mutations, with targeted detection and sequencing revealing consistent variant data between wastewater and clinical samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Wei Lin Lee et al.
Summary: This study developed a detection method for tracking the B.1.1.7 variant in wastewater, which can reliably detect low levels of B.1.1.7 and provide rapid and inexpensive surveillance of SARS-CoV-2 variants.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2021)
Article
Medicine, General & Internal
Agathe Boudet et al.
Summary: This study evaluated an RT-PCR kit for screening SARS-CoV-2 variants in France, with 4.1% of samples suspected to belong to B.1.351 or P.1 variants, but only 75.8% confirmed as B.1.351. Mutations near the H69/V70 deletion in the S-gene were found in samples of the UK variant, impacting the detection.
Article
Health Policy & Services
Edward H. Kaplan et al.
Summary: Determining the state of coronavirus outbreaks is crucial for making public health decisions. Researchers have found that SARS-CoV-2 RNA can be detected in municipal sewage sludge, providing an earlier signal of infection than hospital admissions data. A model was developed to estimate the incidence of infection and the transmission dynamics translated into infection indicators, showing that 89% of the population may have been removed from the risk of infection with the remaining 11% exposed to an outbreak that infected 9.3% of the total population.
HEALTH CARE MANAGEMENT SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Jordan Peccia et al.
NATURE BIOTECHNOLOGY
(2020)
Article
Engineering, Environmental
I Michael-Kordatou et al.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2020)
Review
Microbiology
Nathan D. Grubaugh et al.
NATURE MICROBIOLOGY
(2019)
Article
Engineering, Environmental
Nikolaos S. Thomaidis et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2016)
Article
Engineering, Environmental
K. E. Gibson et al.
Article
Biochemical Research Methods
Heng Li et al.
