Polyhalogenated carbazoles in indoor dust from Hangzhou, China

Carbazoles (CZ) and polyhalogenated carbazoles (PHCZs), showing dioxin-like toxicity, have gained increasing atten-tion in recent years as novel persistent organic pollutants. However, the occurrence of these chemicals in indoor dust from China remains not well known. In this study, CZ and 11 chloro/bromo CZs were analyzed in indoor dust samples collected from residential houses in rural (n = 51) and urban (n = 55) regions of Hangzhou, China. CZ was detected in all indoor dust samples, with the concentrations of 0.81-18 ng/g (mean 5.4 ng/g). All 11 measured PHCZs were de-tected in indoor dust samples, showing the detection frequency of 7.3-96 %. This means that general populations had wide exposure to CZ and PHCZs through indoor dust ingestion. 3,6-dichlorocarbzole (36-CCZ) and 3,6-dibromocarbazole (36-BCZ) were the predominant PHCZs in indoor dust, having comparable mean concentrations of 1.2 ng/g, followed by 3-monobromocarbazole (3-BCZ; mean 0.66 ng/g, range < LOD-2.1 ng/g) and 1,3,6-tribromocarbazole (136-BCZ; 0.36 ng/g, < LOD-1. 0 ng/g). Indoor dust concentrations of 3-BCZ, 36-BCZ, and 1,3,6,8-tetrabromocarbazole in urban regions were significantly (p <= 0.01-0.035) higher than that in rural regions. Daily intakes (DIs) of CZ and PHCZs through indoor dust ingestion were estimated for general Chinese population. Among PHCZs, 36-CCZ and 36-BCZ (mean 1.4-3.4 pg/kg bw/day) had the highest mean DIs, followed by 3-BCZ (0.77-1.9 pg/kg bw/day) and 136-BCZ (0.42-1.0 pg/kg/day). To our knowledge, this is the first study reporting the concentrations of CZ and PHCZs in indoor dust from China, which contributes to the better understanding of the sources of human exposure to CZ and PHCZs.

Automated summary

This study investigated the levels of carbazoles (CZ) and polyhalogenated carbazoles (PHCZs) in indoor dust samples from rural (n=51) and urban (n=55) areas of Hangzhou, China. CZ and PHCZs were found to be widely present in indoor dust, indicating general exposure through indoor dust ingestion. Concentrations of 3-BCZ, 36-BCZ, and 1,3,6,8-tetrabromocarbazole were significantly higher in urban areas compared to rural areas. Daily intakes of CZ and PHCZs through indoor dust ingestion were estimated for the general Chinese population.