Reaction of 1H-pyrrole-2,3-diones with malononitrile and aminocyclohexenones: synthesis of spiro[pyrrole-3,4'-quinolines]

New polyhydroquinolines spiroannulated with the pyrrol-2-one moiety were synthesized by the 4-dimethylaminopyridine-catalyzed three-component reaction of 1H-pyrrole-2,3-diones with malononitrile and aminocyclohexenones. The synthesized polyhydroquinolines exhibit antioxidant activity.

Automated summary

New polyhydroquinolines spiroannulated with the pyrrol-2-one motif were synthesized using the 4-dimethylaminopyridine-catalyzed three-component reaction. The synthesized compounds exhibited antioxidant activity.