期刊
RESEARCH IN VETERINARY SCIENCE
卷 152, 期 -, 页码 647-650出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2022.09.037
关键词
CTX-M; ESBL; Livestock; Escherichia coli; Antimicrobial resistance
资金
- Belgian Federal Public Service Health, Food Chain Safety and Environment
- [RF 17/6317 RU-BLA-ESBL-CPE]
Escherichia coli producing Extended-Spectrum-beta-Lactamases (ESBL) are a major global public health hazard. This study aimed to determine the prevalence of ESBL in pathogenic and non-pathogenic E. coli isolated from young diarrheic and septicaemic calves over three calving seasons. The results showed a gradual decrease in ESBL-resistance in pathogenic E. coli, with no significant difference in genetic background or CTX-M content between pathogenic and non-pathogenic E. coli.
Escherichia coli producing Extended-Spectrum-beta-Lactamases (ESBL) are a major public health hazard worldwide. The most frequent ESBL belong to the CTX-M family. This study follows their prevalence in pathogenic and non-pathogenic ESBL-producing E. coli isolated from young diarrheic and septicaemic calves over three calving seasons. The triplex PCR targeted three main groups: CTX-M-1, CTX-M-2 and CTX-M-9. Of the 394 isolates studied, 388 (98.5%) were positive, with a majority of CTX-M-1 (243, 61.7%), following by CTX-M-9 (74, 18.8%) and CTX-M-2 (64, 16.2%). The progressive decrease of ESBL-resistance of pathogenic E. coli is not linked to any shift in genetic background, blaCTX-M genes still present in 99% of the isolates, or to the proportion of the three CTX-M groups. Moreover, no significant difference was observed in the CTX-M content between pathogenic and non-pathogenic E. coli.
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