Stop GnRH-agonist/GnRH-antagonist protocol: a different insight on ovarian stimulation for IVF

Ovarian stimulation (OS) is one of the key factors in the success of in vitro fertilization-embryo transfer (IVF-ET), by enabling the recruitment of numerous healthy fertilizable oocytes and, thereby, multiple embryos. The Stop GnRH-agonist/GnRH-antagonist (GnRH-ag/GnRH-ant), which offers all the advantages of using long suppressive GnRH-ag, with GnRH-ant, is in my opinion a valuable addition to the armamentarium of OS protocols. It allows cycle programming, better follicular synchronization and offers successful outcome in a variety of challenging cases such as poor responders, Poseidon group 4 poor prognosis patients, those with elevated peak progesterone (P) serum levels, poor embryo quality or repeated IVF failures.

Automated summary

Ovarian stimulation is crucial for the success of in vitro fertilization-embryo transfer, and the use of GnRH-ag/GnRH-ant can enhance its effectiveness in challenging cases such as poor responders and patients with elevated progesterone levels. It allows better cycle programming and follicular synchronization, resulting in successful outcomes.