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Chronic fatigue and affective symptoms in acute and long COVID are attributable to immune-inflammatory pathways

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Summary: This study aims to investigate the associations between affective and chronic fatigue syndrome-like symptoms and chest CT scan anomalies, oxygen saturation, inflammatory biomarkers, etc. in COVID-19 patients. The results showed that the immune response core was associated with lung lesions and affective and physiosomatic symptoms. The infection-immune-inflammatory core plays a significant role in pneumonia-associated CT scan anomalies, decreased oxygen saturation, and immune activation, and it affects the affective and neuropsychiatric symptoms of patients.

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ACTA NEUROPSYCHIATRICA (2022)

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Lowered Quality of Life in Long COVID Is Predicted by Affective Symptoms, Chronic Fatigue Syndrome, Inflammation and Neuroimmunotoxic Pathways

Michael Maes et al.

Summary: The study aims to investigate the effects of temperature and oxygen saturation during acute infection, as well as neurotoxicity on the quality of life in Long COVID patients. The results showed that 70.3% of the variance in quality of life can be explained by the physio-affective phenome, lowered calcium, and increased neurotoxicity. Furthermore, 61.5% of the variance in the physio-affective phenome can be explained by factors such as calcium, neurotoxicity, increased temperature, lowered oxygen saturation, female sex, and vaccination. The effects of temperature and oxygen saturation on lowered quality of life are mediated by increased neurotoxicity and lowered calcium.

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Persistent symptoms 1.5-6 months after COVID-19 in non-hospitalised subjects: a population-based cohort study

Knut Stavem et al.

Summary: The study assessed symptoms and their determinants 1.5-6 months after symptom onset in non-hospitalised subjects with confirmed COVID-19 until 1 June 2020. Findings showed that individuals reported fewer symptoms after 1.5-6 months compared to during the acute COVID-19 phase, with persistent symptoms being associated with the number of comorbidities and symptoms experienced during the acute phase.

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Summary: This study aimed to identify studies assessing the long-term effects of COVID-19, estimating that 80% of infected patients will develop one or more long-term symptoms, with the most common being fatigue, headache, attention disorder, hair loss, and dyspnea.

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6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records

Maxime Taquet et al.

Summary: Our study provides evidence of significant neurological and psychiatric morbidity in the 6 months following COVID-19 infection. The risks were highest in patients with severe COVID-19. This information could assist in service planning and research priority identification.

LANCET PSYCHIATRY (2021)