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Article
Clinical Neurology
Hawraa Kadhem Al-Jassas et al.
Summary: This study aims to investigate the associations between affective and chronic fatigue syndrome-like symptoms and chest CT scan anomalies, oxygen saturation, inflammatory biomarkers, etc. in COVID-19 patients. The results showed that the immune response core was associated with lung lesions and affective and physiosomatic symptoms. The infection-immune-inflammatory core plays a significant role in pneumonia-associated CT scan anomalies, decreased oxygen saturation, and immune activation, and it affects the affective and neuropsychiatric symptoms of patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
Michael Maes et al.
Summary: There is evidence that chronic fatigue spectrum disorders (CFAS-Ds), including myalgic encephalomyelitis (ME), chronic fatigue syndrome (CFS), and chronic fatigue with physiosomatic symptoms, are characterized by neuroimmune and neuro-oxidative biomarkers. This study aimed to analyze the protein-protein interaction (PPI) network of CFAS-D and discover the enriched pathways, molecular patterns, and domains. The results revealed a highly connected network involving immune-oxidative-nitrosative and Wnt/beta-catenin subnetworks. The CFAS-D network was found to be associated with detoxification, inflammatory signaling, and dysfunctions in multicellular organismal homeostatic processes.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Dhurgham Shihab Al-Hadrawi et al.
Summary: This study aims to explore the physio-affective phenome of long coronavirus disease 2019 (LC) and investigate the effects of oxygen saturation (SpO2) and body temperature during the acute phase on LC. The results indicate that lowered SpO2 and increased body temperature during the acute phase, as well as female sex, can predict the physio-affective phenome of LC. Additionally, a new endophenotype class, characterized by very low SpO2 and very high body temperature, and associated with depression, anxiety, chronic fatigue, and autonomic and gastro-intestinal symptoms, was identified.
ACTA NEUROPSYCHIATRICA
(2022)
Article
Environmental Sciences
Michael Maes et al.
Summary: The study aims to investigate the effects of temperature and oxygen saturation during acute infection, as well as neurotoxicity on the quality of life in Long COVID patients. The results showed that 70.3% of the variance in quality of life can be explained by the physio-affective phenome, lowered calcium, and increased neurotoxicity. Furthermore, 61.5% of the variance in the physio-affective phenome can be explained by factors such as calcium, neurotoxicity, increased temperature, lowered oxygen saturation, female sex, and vaccination. The effects of temperature and oxygen saturation on lowered quality of life are mediated by increased neurotoxicity and lowered calcium.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Respiratory System
Knut Stavem et al.
Summary: The study assessed symptoms and their determinants 1.5-6 months after symptom onset in non-hospitalised subjects with confirmed COVID-19 until 1 June 2020. Findings showed that individuals reported fewer symptoms after 1.5-6 months compared to during the acute COVID-19 phase, with persistent symptoms being associated with the number of comorbidities and symptoms experienced during the acute phase.
Article
Multidisciplinary Sciences
Sandra Lopez-Leon et al.
Summary: This study aimed to identify studies assessing the long-term effects of COVID-19, estimating that 80% of infected patients will develop one or more long-term symptoms, with the most common being fatigue, headache, attention disorder, hair loss, and dyspnea.
SCIENTIFIC REPORTS
(2021)
Article
Psychiatry
Maxime Taquet et al.
Summary: Our study provides evidence of significant neurological and psychiatric morbidity in the 6 months following COVID-19 infection. The risks were highest in patients with severe COVID-19. This information could assist in service planning and research priority identification.
Review
Behavioral Sciences
Brian Leonard et al.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2012)