The human protein atlas-Integrated omics for single cell mapping of the human proteome

Studying the spatial distribution of proteins provides the basis for understanding the biology, molecular repertoire, and architecture of every human cell. The Human Protein Atlas (HPA) has grown into one of the world's largest biological databases, and in the most recent version, a major update of the structure of the database was performed. The data has now been organized into 10 different comprehensive sections, each summarizing different aspects of the human proteome and the protein-coding genes. In particular, large datasets with information on the single cell type level have been integrated, refining the tissue and cell type specificity and detailing the expression in cell states with an increased resolution. The multi-modal data constitute an important resource for both basic and translational science, and hold promise for integration with novel emerging technologies at the protein and RNA level.

Automated summary

Understanding the spatial distribution of proteins is crucial for comprehending the biology, molecular repertoire, and structure of human cells. The Human Protein Atlas (HPA) has evolved into one of the world's largest biological databases and recently underwent a major update, categorizing the data into 10 comprehensive sections that provide insights into different aspects of the human proteome and protein-coding genes. By integrating large datasets on a single-cell level, the HPA now offers refined information on tissue and cell type specificity, as well as detailed expression profiles in various cell states.