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Signal integration in the endoplasmic reticulum unfolded protein response
David Ron et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
D. R. Laybutt et al.
DIABETOLOGIA (2007)
Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells
Pierre Pirot et al.
DIABETES (2007)
Activation of the unfolded protein response in Parkinson's disease
J. J. M. Hoozemans et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1 (S)-induced endoplasmic reticulum biogenesis
Rungtawan Sriburi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Selective inhibition of eukaryotic translation initiation factor 2α dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic β-cell dysfunction and apoptosis
Miriam Cnop et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Understanding and addressing the epidemic of obesity: An energy balance perspective
James O. Hill
ENDOCRINE REVIEWS (2006)
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
Kathryn L. Lipson et al.
CELL METABOLISM (2006)
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
Marc-Emmanuel Dumas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
α-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
Antony A. Cooper et al.
SCIENCE (2006)
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis
Elizabeth Karaskov et al.
ENDOCRINOLOGY (2006)
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression
P Hu et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response
H Yoshida et al.
JOURNAL OF CELL BIOLOGY (2006)
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
KZ Zhang et al.
CELL (2006)
The unfolded protein response - A stress signaling pathway critical for health and disease
KZ Zhang et al.
NEUROLOGY (2006)
Membrane curvature and mechanisms of dynamic cell membrane remodelling
HT McMahon et al.
NATURE (2005)
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic β-cells
SG Fonseca et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The unfolded protein response is activated in Alzheimer's disease
JJM Hoozemans et al.
ACTA NEUROPATHOLOGICA (2005)
A comprehensive classification system for lipids
E Fahy et al.
JOURNAL OF LIPID RESEARCH (2005)
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic β-cells
AK Cardozo et al.
DIABETES (2005)
Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44
T Higo et al.
CELL (2005)
ER stress and the unfolded protein response
M Schröder et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2005)
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
SJ Marciniak et al.
GENES & DEVELOPMENT (2004)
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2
J Deng et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Free fatty acids and Cytokines induce pancreatic β-cell apoptosis by different mechanisms:: Role of nuclear factor-κB and endoplasmic reticulum stress
I Kharroubi et al.
ENDOCRINOLOGY (2004)
S-glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide
T Adachi et al.
NATURE MEDICINE (2004)
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
JD Horton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages
B Feng et al.
NATURE CELL BIOLOGY (2003)
Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins
Y Kimata et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of golgi localization signals
JS Shen et al.
DEVELOPMENTAL CELL (2002)
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
H Yoshida et al.
CELL (2001)
Translational control is required for the unfolded protein response and in vivo glucose homeostasis
D Scheuner et al.
MOLECULAR CELL (2001)
CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression
Y Omori et al.
NUCLEIC ACIDS RESEARCH (2001)
Increased sensitivity to dextran sodium sulfate colitis in IRE1β-deficient mice
A Bertolotti et al.
JOURNAL OF CLINICAL INVESTIGATION (2001)
Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress
T Iwawaki et al.
NATURE CELL BIOLOGY (2001)
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum
CY Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes
A Nohturfft et al.
CELL (2000)
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
A Bertolotti et al.
NATURE CELL BIOLOGY (2000)
Perk is essential for translational regulation and cell survival during the unfolded protein response
HP Harding et al.
MOLECULAR CELL (2000)
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