Research Note: Dietary resveratrol supplementation improves the hepatic antioxidant capacity and attenuates lipopolysaccharide-induced inflammation in yellow-feathered broilers

This experiment investigated the protec-tive effect of resveratrol (RES) on the hepatic antioxi-dant status and systemic inflammation in yellow -feathered broilers challenged with lipopolysaccharide (LPS). A total of 240 healthy 1-day-old yellow -feath-ered broilers were randomly divided into 4 groups (con-trol, LPS, RES, and RES+LPS), with 5 replicates of 12 chickens per replicate. The experiment lasted 21 d. The broilers were fed with either the basal diet or the basal diet supplemented with 400 mg/kg RES followed by intraperitoneal challenge with LPS (1 mg/kg body weight) or the same amount of saline at d 16, 18, and 20. The results showed that dietary RES supplementation could improve the activities of total antioxidant capac-ity (T-AOC) and superoxide dismutase (SOD) in the liver of yellow-feathered broilers challenged with LPS (P < 0.05). Furthermore, LPS challenge increased the plasma interleukin-17 (IL-17) concentration, the hepatic interleukin-6 (IL-6) and interleukin-1/3 (IL-1b) concentrations, as well as the concentrations of tumor necrosis factor (TNF-a), IL-6, and IL-1/3 in the spleen (P < 0.05), and decreased the transforming growth fac-tor-/3 (TGF-b) concentrations in the plasma, liver, and spleen (P < 0.05). However, dietary RES supplementa-tion could reduce the increased TNF-a levels in the plasma, liver, and spleen induced by LPS, and increased TGF-/3 level in the liver and spleen (P < 0.05). Collec-tively, these results suggest that dietary RES supple-mentation could effectively improve the hepatic antioxidant capacity and attenuate LPS-induced inflammation in yellow-feathered broilers during the starter

Automated summary

This study investigated the protective effect of resveratrol (RES) on the hepatic antioxidant status and systemic inflammation in yellow-feathered broilers challenged with lipopolysaccharide (LPS). The results showed that dietary RES supplementation could improve the antioxidant capacity and attenuate LPS-induced inflammation in the liver of yellow-feathered broilers.