期刊
CELL AND TISSUE RESEARCH
卷 363, 期 1, 页码 69-84出版社
SPRINGER
DOI: 10.1007/s00441-015-2269-6
关键词
Oocyte; Translation; RNA; RNP; Meiosis
类别
资金
- Institutional Research Concept [RVO67985904]
- [GACR 13-12291S]
- [GACR 15-22765S/502]
- [GACR P502122201]
A hallmark of oocyte development in mammals is the dependence on the translation and utilization of stored RNA and proteins rather than the de novo transcription of genes in order to sustain meiotic progression and early embryo development. In the absence of transcription, the completion of meiosis and early embryo development in mammals relies significantly on maternally synthesized RNAs. Posttranscriptional control of gene expression at the translational level has emerged as an important cellular function in normal development. Therefore, the regulation of gene expression in oocytes is controlled almost exclusively at the level of mRNA and protein stabilization and protein synthesis. This current review is focused on the recently emerged findings on RNA distribution related to the temporal and spatial translational control of the meiotic progression of the mammalian oocyte.
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