期刊
POLYMERS FOR ADVANCED TECHNOLOGIES
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/pat.5931
关键词
anticancer activity; breast cancer; core-shell nanofibers; in vivo; multi-walled carbon nanotubes
资金
- Alborz University of Medical Sciences
In this study, paclitaxel, multi-walled carbon nanotubes, and doxorubicin were doped into poly(epsilon-caprolactone)/chitosan/zein core-shell nanofibers to increase their cytotoxicity for breast cancer cells. The synthesized nanofibers showed sustained release of drugs and high biocompatibility, effectively inhibiting tumor growth.
In the present study, paclitaxel (PTX), multi-walled carbon nanotubes (MWCNTs), and doxorubicin (DOX) have been simultaneously doped into the poly(epsilon-caprolactone) (PCL)/chitosan/zein core-shell nanofibers to increase its cytotoxicity for MCF-7 breast cancers killing. The physico-chemical properties of synthesized nanofibers were determined by scanning electron microscope, Fourier-transform infrared spectroscopy, tensile strength, and degradation rate determinations. The in vitro release studies demonstrated the sustained release of drugs from core-shell nanofibrous scaffold. The cytotoxicity and compatibility of core-shell nanofibers were investigated by their treating with MCF-7 breast cancer cells and L929 normal cells, respectively. PCL/PTX/chitosan/zein/MWCNTs/DOX core-shell nanofibers containing 1 wt% MWCNTs, 100 mu g ml(-1) DOX and 100 mu g ml(-1) PTX had a high biocompatibility with a 84% MCF-7 cancer cells killing. The in vivo studies revealed the synergic effects of MWCNTs and anticancer drugs on the tumor inhibition. This method could be considered as a new way for developing of MWCNTs loaded-nanofibers for cancer treatment in future.
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