期刊
POLYMER CHEMISTRY
卷 14, 期 1, 页码 71-80出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2py01250b
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资金
- Ministerio de Economia y Competitividad Programa Excelencia (MINECO)-FEDERMinisterio de Economia y Competitividad Programa Excelencia (MINECO)-FEDER [PID2021-126132NB-I00]
- Ministerio de Economia y Competitividad Programa Generacion de Conocimiento (MICINN)-FEDER [EXC-2082/1-390761711]
- Ministerio de Economia y Competitividad Fondo Social Europeo and Gobierno de Aragon
- Fondo Social Europeo
- Excellence Cluster 3D Matter Made to Order
- Carl Zeiss Foundation through the Carl-Zeiss-Foundation-Focus@HEiKA
- Helmholtz program Materials Systems Engineering (MSE) at the Karlsruhe Institute of Technology
- Ministerio de Economia y Competitividad Fondo Europeo de Desarrollo Regional , FEDER 2014-2020 Construyendo Europa desde Aragon) [E47-17R]
- Gobierno de Aragon
- [MAT2017-84838-P]
Self-assemblies containing the nucleobase analogue 2,6-diacylaminopyridine were prepared by aqueous seeded RAFT polymerization for the first time, with a phase diagram generated from the systematic variation of polymerization degree and solid concentration. Various morphologies of self-assemblies were observed and shown to be stable for almost a year, with successful loading and release of Nile Red demonstrated in both supramolecular cross-linked and non-cross-linked systems.
Self-assemblies containing the nucleobase analogue 2,6-diacylaminopyridine (DAP) have been successfully prepared for the first time by aqueous seeded RAFT polymerization in high concentrations. For this purpose, a diblock copolymer containing poly(ethylene glycol) (PEG) and DAP polymethacrylate blocks was used as a macro-chain-transfer agent (PEG(124)-b-PDAP(9)-CTA) for the polymerization of 2-hydroxypropyl methacrylate (HPMA) in water. From the systematic variation of the degree of polymerization and solid concentration, a phase diagram has been generated that correlates both variables with the morphologies of this new system. Self-assemblies have been characterized by TEM and DLS, observing morphologies from low to high order (from spherical micelles to worms and to vesicles). Self-assembly morphologies are stable for almost a year, except in the case of worms that turn into spherical micelles after a few weeks. In addition, H-bonding supramolecular functionalization of the DAP repeating units during aqueous seeded RAFT polymerization has been examined by functionalization with a cross-linker with four thymine groups. Finally, the loading and the subsequent release of Nile Red have been proven in both supramolecular cross-linked and non-cross-linked self-assemblies.
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