Reduced isometric knee extensor force following anodal transcranial direct current stimulation of the ipsilateral motor cortex

BackgroundThe goal of this study was to determine if 10-min of anodal transcranial direct current stimulation (a-tDCS) to the motor cortex (M1) is capable of modulating quadriceps isometric maximal voluntary contraction (MVC) force or fatigue endurance contralateral or ipsilateral to the stimulation site. MethodsIn a randomized, cross-over design, 16 (8 females) individuals underwent two sessions of a-tDCS and two sham tDCS (s-tDCS) sessions targeting the left M1 (all participants were right limb dominant), with testing of either the left (ipsilateral) or right (contralateral) quadriceps. Knee extensor (KE) MVC force was recorded prior to and following the a-tDCS and s-tDCS protocols. Additionally, a repetitive MVC fatiguing protocol (12 MVCs with work-rest ratio of 5:10-s) was completed following each tDCS protocol. ResultsThere was a significant interaction effect for stimulation condition x leg tested x time [F-(1,F-60) = 7.156, p = 0.010, eta p(2) = 0.11], which revealed a significant absolute KE MVC force reduction in the contralateral leg following s-tDCS (p < 0.001, d = 1.2) and in the ipsilateral leg following a-tDCS (p < 0.001, d = 1.09). A significant interaction effect for condition x leg tested [F-(1,F-56) = 8.12, p = 0.006, eta p(2) = 0.13], showed a significantly lower ipsilateral quadriceps (to tDCS) relative MVC force with a-tDCS, versus s-tDCS [t(15) = -3.07, p = 0.016, d = -0.77]. There was no significant difference between the relative contralateral quadriceps (to tDCS) MVC force for a-tDCS and s-tDCS. Although there was an overall significant [F-(1,F-56) = 8.36, p < 0.001] 12.1% force decrease between the first and twelfth MVC repetitions, there were no significant main or interaction effects for fatigue index force. Conclusiona-tDCS may be ineffective at increasing maximal force or endurance and instead may be detrimental to quadriceps force production.

Automated summary

The study aimed to investigate the effects of 10-min of anodal transcranial direct current stimulation (a-tDCS) on quadriceps isometric maximal voluntary contraction (MVC) force and fatigue endurance. The results showed that a-tDCS led to a significant reduction in absolute MVC force in the ipsilateral leg, while s-tDCS caused a significant reduction in the contralateral leg. Furthermore, a-tDCS resulted in significantly lower relative MVC force in the ipsilateral quadriceps compared to s-tDCS. The findings suggest that a-tDCS may not effectively enhance maximal force or endurance and could potentially impair quadriceps force production.