Association between circulating SerpinB1 levels and insulin sensitivity in Japanese with type 2 diabetes: A single-center, cross-sectional, observational study

Plasma and liver SerpinB1 levels are elevated in mice with insulin resistance and promote beta-cell proliferation in human islets. We measured serum SerpinB1 levels in Japanese subjects with or without type 2 diabetes (T2DM). We enrolled 12 normal glucose tolerance (NGT) and 51 T2DM subjects. There was no difference in serum SerpinB1 levels between the 2 groups (T2DM, 1.3 0.9 ng/mL vs. NGT, 1.8 +/- 1.7 ng/mL; P = 0.146). After adjusting for age and sex, the serum SerpinB1 levels were positively correlated with HOMA2-%S (beta = 0.319, P = 0.036), and negatively correlated with fasting blood glucose (beta = -0.365, P = 0.010), total cholesterol (beta = -0.396, P = 0.006), low-density lipoprotein (LDL) cholesterol (beta = -0.411, P = 0.004), triglycerides (beta = -0.321, P = 0.026), and gamma GTP (beta = -0.322, P = 0.026) in subjects with T2DM. Thus, circulating SerpinB1 is possibly associated with insulin sensitivity and better blood glucose level in Japanese subjects with T2DM.

Automated summary

This study found that serum SerpinB1 levels in patients with T2DM are associated with insulin sensitivity and blood glucose levels.