☆ 4.7 Article

Rosmarinic acid potentiates and detoxifies tacrine in combination for Alzheimer's disease

PHYTOMEDICINE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

In Silico Molecular Docking Approach Against Enzymes Causing Alzheimer's Disease Using Borassus flabellifer Linn

Jason Tom Abraham et al.

Summary: Alzheimer's disease is a life-threatening neurodegenerative disorder that causes cognitive impairment and memory loss. Researchers have discovered natural compounds isolated from the haustoria of palmyra palm that show activity against Alzheimer's disease-causing enzymes and potential as a drug.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Design, Synthesis, biological investigations and molecular interactions of triazole linked tacrine glycoconjugates as Acetylcholinesterase inhibitors with reduced hepatotoxicity

Harmandeep Kaur Gulati et al.

Summary: This study successfully reduced the hepatotoxicity of Tacrine by synthesizing Tacrine-linked sugar conjugates, and identified one compound with good AChE inhibition activity, which can be further explored for its mechanism of action in Alzheimer's disease treatment.

BIOORGANIC CHEMISTRY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Beneficial Effects of Combining Anti-Aβ Antibody NP106 and Curcumin Analog TML-6 on the Treatment of Alzheimer's Disease in APP/PS1 Mice

Ih-Jen Su et al.

Summary: Research showed that a combination treatment (anti-Aβ antibody NP106 and curcumin analog TML-6) can more effectively lower Aβ levels, improve behavioral deficits, and normalize gut microbiota, providing a new avenue for developing more effective AD treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Immunology

Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer's disease

Laura D. Owlett et al.

Summary: Gas6 overexpression reduces plaque burden but increases pro-inflammatory signaling and worsens behavior in an Alzheimer's disease model. Gas6 overexpression appears to have no effect on phagocytic mechanisms in vitro or in vivo.

JOURNAL OF NEUROINFLAMMATION (2022)

添加到收藏夹

Article Clinical Neurology

Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study

Jasmeer P. Chhatwal et al.

Summary: Insights gained from studying individuals with autosomal dominant Alzheimer's disease have broadly influenced mechanistic hypotheses, biomarker development, and clinical trials. Despite highly penetrant pathogenic variants causing autosomal dominant Alzheimer's disease, there is substantial heterogeneity in levels of amyloid 13 (A13) between individuals. Variant-dependent variability in PiB-PET signal was observed in individuals with autosomal dominant Alzheimer's disease, suggesting the need for further research into the disease progression and biomarker associations.

LANCET NEUROLOGY (2022)

添加到收藏夹

Article Nutrition & Dietetics

Phenolic Acids and Prevention of Cognitive Decline: Polyphenols with a Neuroprotective Role in Cognitive Disorders and Alzheimer's Disease

Giuseppe Caruso et al.

Summary: Cognitive impairment is a significant public health problem associated with normal aging and neurodegenerative disorders. Dietary polyphenols, particularly phenolic acids, play an important role in healthy aging and the prevention of cognitive decline.

NUTRIENTS (2022)

添加到收藏夹

Article Clinical Neurology

Cholinergic receptor binding in unimpaired older adults, mild cognitive impairment, and Alzheimer's disease dementia

David L. Sultzer et al.

Summary: This study found lower nicotinic cholinergic receptor binding in specific limbic and subcortical regions in MCI and AD dementia patients compared to CU older adults, which is related to cognitive deficits.

ALZHEIMERS RESEARCH & THERAPY (2022)

添加到收藏夹

Article Clinical Neurology

Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease

Jaclyn M. Eissman et al.

Summary: Approximately 30% of elderly adults with Alzheimer's disease neuropathology show no cognitive decline. This study investigated the genetic factors contributing to resilience to cognitive consequences of Alzheimer's disease neuropathology in a sex-specific manner. The results identified a female-specific resilience locus and highlighted numerous sex-specific molecular pathways related to resilience. These findings suggest the importance of personalized treatment based on sex and genetic factors.

BRAIN (2022)

添加到收藏夹

Article Chemistry, Medicinal

Novel inhibitors of AChE and A0 aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease

Yulin Liu et al.

Summary: A series of new AChE inhibitors were designed and synthesized, among which compound 24r showed strong inhibitory activity and neuroprotective effects, indicating its potential applications in the treatment of Alzheimer's disease.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery

K. Dileep et al.

Summary: Alzheimer's disease is a common neurodegenerative disorder in the elderly population, and impairment of the cholinergic system is a critical factor for its progression. Tacrine, as an AChE inhibitor, is promising for restoring cholinergic transmission. This study reveals the atomic level interactions between tacrine and human AChE, providing a mechanistic explanation for its high binding affinity.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Kinetic Modeling of Time-Dependent Enzyme Inhibition by Pre-Steady-State Analysis of Progress Curves: The Case Study of the Anti-Alzheimer's Drug Galantamine

Doriano Lamba et al.

Summary: This study shows that the conventional analysis of initial velocities fails to accurately describe the inhibition mechanism of long drug-target residence time inhibitors, leading to a potential underestimation of drug potency.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

In silico analyses of acetylcholinesterase (AChE) and its genetic variants in interaction with the anti-Alzheimer drug Rivastigmine

Gabriel Rodrigues Coutinho Pereira et al.

Summary: Alzheimer's disease (AD) is the leading cause of dementia worldwide. In this study, computer simulations and machine learning algorithms were used to evaluate the effects of AChE mutations on protein structure and interaction with rivastigmine. The findings suggest that certain mutations may have harmful consequences on protein function, and that the binding of rivastigmine to hAChE is an energetically favorable process mainly driven by negatively charged amino acids.

JOURNAL OF CELLULAR BIOCHEMISTRY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Design, synthesis and biological evaluation of novel N-phosphorylated and O-phosphorylated tacrine derivatives as potential drugs against Alzheimer's disease

Maja Przybylowska et al.

Summary: In this study, a series of N- and O-phosphorylated tacrine derivatives were designed, synthesized, and biologically investigated. The results suggest that some of these derivatives have potential anti-Alzheimer's disease properties.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2022)

添加到收藏夹

Article Immunology

The significance of glycolysis index and its correlations with immune infiltrates in Alzheimer's disease

Zhiqiang Qiu et al.

Summary: This study revealed the clinical and biological significance of glycolysis and the brain microenvironment in Alzheimer's disease (AD).

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Discovery of novel β-carboline-1,2,3-triazole hybrids as AChE/GSK-3β dual inhibitors for Alzheimer's disease treatment

Wenjie Liu et al.

Summary: This study designed and synthesized a series of 17 beta-carboline-1,2,3-triazole hybrids, and evaluated their inhibitory potential on AD targets AChE and GSK-3 beta. Compound 21 showed the most potent inhibition and had effects on tau hyperphosphorylation, indicating its potential therapeutic value for AD.

BIOORGANIC CHEMISTRY (2022)

添加到收藏夹

Article Clinical Neurology

2022 Alzheimer's disease facts and figures

Joseph Gaugler et al.

Summary: This article discusses the impact of Alzheimer's disease on public health, including its incidence, prevalence, mortality and morbidity rates, healthcare costs and caregivers' burden. It also addresses the perspectives of consumers and primary care physicians on mild cognitive impairment (MCI) and the need for improved awareness, diagnosis, and treatment. The article emphasizes the increasing number of individuals living with Alzheimer's and the challenges faced by caregivers and healthcare providers, particularly during the COVID-19 pandemic.

ALZHEIMERS & DEMENTIA (2022)

添加到收藏夹

Review Neurosciences

Neurodegenerative Pathways in Alzheimer's Disease: A Review

Anu Kunnath Ramachandran et al.

Summary: Alzheimer's disease is a complex neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes, leading to a low quality of life for patients. The disease involves a variety of neuropathological mechanisms, with no current cure or effective disease-modifying therapies available.

CURRENT NEUROPHARMACOLOGY (2021)

添加到收藏夹

Review Chemistry, Medicinal

From combinations to multitarget-directed ligands: A continuum in Alzheimer's disease polypharmacology

Claudia Albertini et al.

Summary: Despite the failures in drug discovery for complex neurodegenerative diseases like AD, the rise of awareness regarding polypharmacological approaches, using pharmaceutical agents acting on multiple targets, presents a promising avenue for restoring the diseased network and providing disease-modifying effects. Understanding the advantages and drawbacks of different modalities in drug discovery is crucial for developing successful AD multitarget drug-discovery endeavors. Researchers aiming to enter and progress in this field are encouraged to explore the full potential of AD polypharmacology.

MEDICINAL RESEARCH REVIEWS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling

Jieun Kim et al.

Summary: The study demonstrated that donepezil significantly reduces LPS- and A beta-induced neuroinflammatory responses in vitro and in vivo, suggesting it may be a therapeutic agent for neuroinflammation-associated diseases such as Alzheimer's disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Icariin ameliorate Alzheimer's disease by influencing SIRT1 and inhibiting Aβ cascade pathogenesis

Yaochen Chuang et al.

Summary: Alzheimer's disease, with the highest proportion of cases among all types of dementia, is closely associated with the aggregation of amyloid-beta protein. Icariin, the main ingredient extracted from Epimedium, may ameliorate Alzheimer's disease by regulating Sirtuin1 to inhibit amyloid-beta protein and improve other amyloid-beta cascade pathogenesis, providing a reference for future treatment strategies.

JOURNAL OF CHEMICAL NEUROANATOMY (2021)

添加到收藏夹

Review Medicine, General & Internal

Alzheimer's disease

Philip Scheltens et al.

Summary: Alzheimer's disease is projected to see a significant increase in prevalence in the future, with genetics playing a key role. Novel biomarkers and lifestyle-based prevention trials show promising therapeutic potential. Promising pharmacological treatments are advancing in clinical trials, targeting amyloid beta, tau, and inflammation.

LANCET (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A novel in vitro assay model developed to measure both extracellular and intracellular acetylcholine levels for screening cholinergic agents

Ryohei Tanaka-Kanegae et al.

Summary: The study developed an in vitro model using the human cholinergic neuroblastoma cell line LA-N-2 to measure both extracellular and intracellular ACh levels. Increases in intracellular ACh levels were more sensitively detected than extracellular ACh levels, even following administration of low AChE-inhibitor doses and an mAChR agonist. Furthermore, the study found that LA-N-2 cells expressed mAChR M2, supporting the hypothesis that the developed assay model can screen compounds for developing treatments for ACh-related conditions like dementia and cognitive decline.

PLOS ONE (2021)

添加到收藏夹

Article Plant Sciences

Rosmarinic acid and ursolic acid alleviate deficits in cognition, synaptic regulation and adult hippocampal neurogenesis in an Aβ1-42-induced mouse model of Alzheimer's disease

Fatima Javed Mirza et al.

Summary: The study demonstrated the proneurogenic effects of rosmarinic acid and ursolic acid in an A beta(1-42)-induced AD mouse model, showing protection against deficits in spatial and recognition memory and changes in anxiety. Treatment with these compounds normalized neuronal density and levels of neurogenic and synaptic markers.

PHYTOMEDICINE (2021)

添加到收藏夹

Article Food Science & Technology

Rosemary Extract and Essential Oil as Drink Ingredients: An Evaluation of Their Chemical Composition, Genotoxicity, Antimicrobial, Antiviral, and Antioxidant Properties

Spyridoula D. Christopoulou et al.

Summary: Rosemary essential oil and extract, with their main compounds identified as eucalyptol and rosmarinic acid respectively, showed good biological properties such as antimicrobial and antioxidant activities. They are safe for use in the drink industry and have the potential to serve as health-promoting ingredients.

FOODS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase

Tereza Cristina Santos Evangelista et al.

Summary: The synthesis of four tetra-tacrine clusters with varying linker lengths attached to a central scaffold was investigated for their multivalent inhibition potencies against acetylcholinesterase. Two of the clusters demonstrated significant binding affinity increases of up to 3.2 times when connected to the central scaffold.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Clinical Neurology

Cholinergic deficits and galaninergic hyperinnervation of the nucleus basalis of Meynert in Alzheimer's disease and Lewy body disorders

A. S. Alexandris et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2020)

添加到收藏夹

Review Neurosciences

Brain injury-induced dysfunction of the blood brain barrier as a risk for dementia

Eric E. Abrahamson et al.

EXPERIMENTAL NEUROLOGY (2020)

添加到收藏夹

Article Cell Biology

Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3β Pathway in Experimental Models of Alzheimer's Disease

Wen Yang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

添加到收藏夹

Article Immunology

Rosmarinic acid protects mice from lipopolysaccharide/D-galactosamine-induced acute liver injury by inhibiting MAPKs/NF-κB and activating Nrf2/HO-1 signaling pathways

Zheng Li et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

添加到收藏夹

Article Immunology

Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling

Jialin Duan et al.

JOURNAL OF NEUROINFLAMMATION (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

Effects of the drug combination memantine and melatonin on impaired memory and brain neuronal deficits in an amyloid-predominant mouse model of Alzheimer's disease

Monika Jurgenson et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2019)

添加到收藏夹

Article Chemistry, Medicinal

Dual GSK-3 beta/AChE Inhibitors as a New Strategy for Multitargeting Anti -Alzheimer's Disease Drug Discovery

Xue-Yang Jiang et al.

ACS MEDICINAL CHEMISTRY LETTERS (2018)

添加到收藏夹

Review Chemistry, Medicinal

A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease

Bilqees Sameem et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Medicinal

Cytochrome P450 binding studies of novel tacrine derivatives: Predicting the risk of hepatotoxicity

Alanna McEneny-King et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Rosmarinic acid inhibits some metabolic enzymes including glutathione S-transferase, lactoperoxidase, acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase isoenzymes

Ilhami Gulcin et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2016)

添加到收藏夹

Article Plant Sciences

Rosmarinic acid stimulates liver regeneration through the mTOR pathway

Kaihan Lou et al.

PHYTOMEDICINE (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Rosemary tea consumption results to anxiolytic- and anti-depressant-like behavior of adult male mice and inhibits all cerebral area and liver cholinesterase activity; phytochemical investigation and in silico studies

Anastasia-Varvara Ferlemi et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2015)

添加到收藏夹

Article Integrative & Complementary Medicine

Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential

Aleksandar Raskovic et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014)

添加到收藏夹

Article Chemistry, Medicinal

Short-Term Study on the Effects of Rosemary on Cognitive Function in an Elderly Population

Andrew Pengelly et al.

JOURNAL OF MEDICINAL FOOD (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors

Jaroslav Sebestik et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2011)

添加到收藏夹

Article Pharmacology & Pharmacy

Rationale for combination therapy with galantamine and Memantine in Alzheimer's disease

George T. Grossberg et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2006)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.