Four new glycosides from Gerbera piloselloides

Four new glycosides, named 3-dehydroxyl dracunculifoside J (1), 4-methoxy divaricataester C (2), 6 '-O-acetyl gerberinside (3), and 4-methoxy marmesinin (4), along with six known compounds (5-10), were isolated from the whole plant of Gerbera piloselloides. Structurally, their structures and absolute configurations were established based on extensive spectroscopic data and X-ray diffraction analysis. Compounds 1-4 were evaluated for the protective effect on lipopolysaccharide (LPS)-induced injury in intestinal epithelial cells (IEC-6). Among them, 3 and 4 could moderately promote the proliferation of LPS-induced IEC-6 cells.

Automated summary

Four new glycosides, along with six known compounds, were isolated from the whole plant of Gerbera piloselloides. Their structures and absolute configurations were determined using extensive spectroscopic data and X-ray diffraction analysis. Among them, compounds 3 and 4 showed moderate promotion of proliferation in lipopolysaccharide-induced intestinal epithelial cells.