期刊
PHYTOCHEMISTRY LETTERS
卷 52, 期 -, 页码 134-137出版社
ELSEVIER
DOI: 10.1016/j.phytol.2022.10.008
关键词
Neopestalotiopsis clavispora; A new ?-pyrone; A new tetramic acid derivative; Estrogenic activity
资金
- Korea University, Korea Polar Research Institute
- [PE22150]
- [NRF-2019R1A2C1006226]
This study discovered biologically active compounds from the extract of Neopestalotiopsis clavispora culture medium and identified a new compound called hymenosetin that showed estrogenic activity.
Estrogen is a vital hormone responsible for the development of the female reproductive system. Hence, estrogen deficiency in menopause increases various symptoms. This study aimed to discover biologically active com-pounds from an EtOAc-extract of Neopestalotiopsis clavispora culture medium which has previously shown es-trogenic activity. A new alpha-pyrone (1) and a new tetramic acid derivative (2), together with hymenosetin (3) and pestalotiollide B (4), were isolated from the extract. The chemical structures of the new compounds were elucidated using MS and NMR spectroscopy, and the absolute configurations were established by quantum mechanical calculations of electronic circular dichroism and gauge-including atomic orbital NMR chemical shift, followed by DP4 + analysis. The isolated compounds were initially tested for their estrogenic activities using MCF-7 estrogen responsive human breast cancer cells. Hymenosetin (3) showed estrogenic activity by increasing the proliferation of MCF-7 cells at the concentration of 2.5 mu M via the phosphorylation of estrogen receptor-alpha.
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