Sesquiterpenoids and monoterpenoids from the water decoction of Valeriana officinalis L

Nine previously undescribed compounds including three sesquiterpenoids, three iridoids, two monoterpenoids and a furan fatty acid, along with seventeen known ones, were isolated from the water decoction of roots and rhizomes of Valerian officinalis L. Structure elucidation of the twenty-six compounds were accomplished by analysis of the extensive spectroscopic data, and the absolute configurations of the nine previously undescribed ones were established by NOESY experiment and the electronic circular dichroism (ECD) simulations. Among them, beta-patchoulene-8-O-beta-D-glucopyranoside, 11-methoxyl-viburtinal, and protocatechuic acid showed anti-neuroinflammatory potentials by significantly inhibiting the secretion of nitric oxide (NO) on BV-2 cells upon LPS stimulation (p < 0.001) without affecting the cell viability.

Automated summary

Nine previously undescribed compounds were isolated from Valerian officinalis L. The structures of these compounds were determined by spectroscopic analysis, and their absolute configurations were established by experiments and simulations. Three of these compounds showed potential anti-neuroinflammatory activity.