OPDA, more than just a jasmonate precursor

The oxylipin 12-oxo-phytodienoic acid (OPDA) is known as a biosynthetic precursor of the important plant hormone jasmonic acid. However, OPDA is also a signaling molecule with functions independent of jasmonates. OPDA involvement in diverse biological processes, from plant defense and stress responses to growth regulation and development, has been documented across plant species. OPDA is synthesized in the plastids from alpha-linolenic acid, and OPDA binding to plastidial cyclophilins activates TGA transcription factors upstream of genes associated with stress responses. Here, we summarize what is known about OPDA metabolism and signaling while briefly discussing its jasmonate dependent and independent roles. We also describe open questions, such as the OPDA protein interactome and biological roles of OPDA conjugates.

Automated summary

The oxylipin 12-oxo-phytodienoic acid (OPDA) is a biosynthetic precursor of the plant hormone jasmonic acid, but also functions as a signaling molecule independent of jasmonates. OPDA is involved in various biological processes across plant species, including defense and stress responses, growth regulation, and development. This article summarizes what is known about OPDA metabolism and signaling, discussing its jasmonate dependent and independent roles, as well as open questions regarding the OPDA protein interactome and biological roles of OPDA conjugates.