☆ 4.6 Review

CGRP PHYSIOLOGY, PHARMACOLOGY, AND THERAPEUTIC TARGETS: MIGRAINE AND BEYOND

PHYSIOLOGICAL REVIEWS (2023)

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Article Clinical Neurology

The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target?

Charlotte Ernstsen et al.

Summary: Using in vivo and ex vivo models, the study shows that PACAP-38 can provoke migraine-like changes independently of CGRP and partially through K-ATP channels. The findings suggest that PACAP-38 antagonism could be a potential alternative therapeutic approach for patients non-responsive to CGRP-targeting therapies.

BRAIN (2022)

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Article Clinical Neurology

Migraine evolution after the cessation of CGRP(-receptor) antibody prophylaxis: a prospective, longitudinal cohort study

Bianca Raffaelli et al.

Summary: The cessation of CGRP(-receptor) antibodies migraine prophylaxis led to a significant increase in migraine frequency and acute medication intake over time. However, by weeks 13-16, the monthly migraine days were not significantly different from baseline values.

CEPHALALGIA (2022)

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Article Clinical Neurology

Salivary CGRP can monitor the different migraine phases: CGRP (in)dependent attacks

Alicia Alpuente et al.

Summary: This study found that salivary CGRP-LI levels were elevated in episodic migraine patients during interictal periods, and usually increased during migraine attacks in most patients. However, not every attack was CGRP-dependent, indicating potential differences in underlying pathophysiology and treatment response.

CEPHALALGIA (2022)

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Editorial Material Clinical Neurology

The chicken and egg problem: CGRP release due to trigeminal activation or vice versa?

Karl Messlinger

CEPHALALGIA (2022)

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Article Endocrinology & Metabolism

Calcitonin Gene Related Peptide, Adrenomedullin, and Adrenomedullin 2 Function in Uterine Artery During Human Pregnancy

Madhu Chauhan et al.

Summary: This study found that the relaxation response of the uterine artery in pregnant women to CGRP, ADM, and ADM2 is increased compared to nonpregnant women. The increase in relaxation sensitivity is mediated by the NO system and endothelium-derived hyperpolarizing factors. Additionally, the receptor system in smooth muscle cells of the uterine artery is adversely affected by vascular disruptors such as sFLT-1 and TNF-alpha.

ENDOCRINOLOGY (2022)

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Article Clinical Neurology

Does wearing off of efficacy occur in galcanezumab-treated patients at the end of the monthly treatment cycle? Post hoc analyses of four phase III randomized trials

Jessica Ailani et al.

Summary: The study aims to determine if migraine patients experience a decrease in the efficacy of galcanezumab at the end of a treatment cycle. The results showed that there were no significant differences in the percentage of patients experiencing wearing off between galcanezumab and placebo treatment groups at the individual patient-level.

HEADACHE (2022)

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Article Genetics & Heredity

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

Heidi Hautakangas et al.

Summary: This study identified 123 susceptibility loci for migraine through genome-wide association analyses and implicated neurovascular mechanisms in its pathophysiology. Subtype analyses revealed risk loci specific for migraine with or without aura, as well as shared risk variants. The findings highlight the importance of both vascular and central nervous system tissue/cell types in the genetic underpinning of migraine.

NATURE GENETICS (2022)

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Article Clinical Neurology

Patient-reported outcomes of migraine treatment with erenumab: results from a national patient survey

Austeja Dapkute et al.

Summary: Despite new therapies, migraine remains undertreated. This study investigates patients' experiences and preferences with erenumab for high frequency episodic and chronic migraine in Lithuania. Results showed that the majority of respondents found erenumab effective and experienced improvement within the first month. Erenumab significantly reduced migraine headache days and frequency, but some patients experienced wearing-off effects during treatment and migraine rebound after discontinuation. Constipation was the most common adverse event. Further research is needed to explore post-cessation deterioration of treatment effect.

NEUROLOGICAL SCIENCES (2022)

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Article Anesthesiology

Automated detection of squint as a sensitive assay of sex-dependent calcitonin gene-related peptide and amylin-induced pain in mice

Brandon J. Rea et al.

Summary: This study developed an automated scanning measurement method for quantifying pain. The method was validated for measuring responses to formalin and calcitonin gene-related peptide stimulation and demonstrated gender differences. The results suggest that the automated scanning measurement method can provide more accurate and real-time pain analysis.

PAIN (2022)

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Article Multidisciplinary Sciences

Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice

Francesco De Logu et al.

Summary: This study reveals that the CGRP-mediated neuronal/Schwann cell pathway mediates allodynia associated with neurogenic inflammation, contributing to the algesic action of CGRP in mice.

NATURE COMMUNICATIONS (2022)

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Review Physiology

Constipation Caused by Anti-calcitonin Gene-Related Peptide Migraine Therapeutics Explained by Antagonism of Calcitonin Gene-Related Peptide's Motor-Stimulating and Prosecretory Function in the Intestine

Peter Holzer et al.

Summary: The development of small-molecule CGRP receptor antagonists and monoclonal antibodies targeting the CGRP system has revolutionized migraine management. However, constipation has been observed as a major adverse event in patients treated with these therapies. This review article investigates the mechanism behind CGRP inhibition-induced constipation.

FRONTIERS IN PHYSIOLOGY (2022)

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Review Physiology

Alpha-Calcitonin Gene Related Peptide: New Therapeutic Strategies for the Treatment and Prevention of Cardiovascular Disease and Migraine

Ambrish Kumar et al.

Summary: Alpha-CGRP plays an important role in cardiovascular disease and migraines. Knock-out studies have shown that α-CGRP deficiency leads to higher mortality rates and cardiac damage in heart failure, while administration of α-CGRP improves cardiac function and protects the heart. In migraines, α-CGRP antagonists can reduce headache symptoms. Both agonists and antagonists of α-CGRP have clinical relevance in treating cardiovascular disease and migraine pain.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Clinical Neurology

Real-World Evidence for the Safety and Efficacy of CGRP Monoclonal Antibody Therapy Added to OnabotulinumtoxinA Treatment for Migraine Prevention in Adult Patients With Chronic Migraine

Laszlo Mechtler et al.

Summary: This study aimed to assess the safety and effectiveness of combining onabotulinumtoxinA with CGRP mAbs for the preventive treatment of chronic migraine. The results showed that the combination treatment was effective in reducing monthly headache days and was safe and well-tolerated. Lack of insurance coverage was the most common reason for discontinuation of the treatment.

FRONTIERS IN NEUROLOGY (2022)

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Article Cell Biology

Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease

E. Evonne Jean et al.

Summary: Communication between the nervous and immune systems at mucosal barrier sites, particularly the respiratory tract, plays a crucial role in protecting host immunity, sensing and responding to various stimuli to induce airway inflammation. Neuropeptides and neurotransmitters have been found to regulate immune cell responses and influence type 2 immunity in the airway.

JOURNAL OF LEUKOCYTE BIOLOGY (2022)

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Review Pharmacology & Pharmacy

Beyond CGRP: The calcitonin peptide family as targets for migraine and pain

Tayla A. Rees et al.

Summary: In addition to CGRP, calcitonin family peptides may be therapeutically useful in treating migraines and other pain disorders. Their localization in peripheral pain pathways could play a role in migraines and pain.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

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Review Pharmacology & Pharmacy

Biological and small molecule strategies in migraine therapy with relation to the calcitonin gene-related peptide family of peptides

Lars Edvinsson et al.

Summary: Migraine is a common neurological disorder affecting up to 15% of the global population. Recent pharmacological treatments targeting CGRP signaling molecules have provided safe and effective options for migraine patients, offering new hope for migraine therapy.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

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Review Pharmacology & Pharmacy

CGRP receptor antagonists for migraine. Are they also AMY1 receptor antagonists?

Michael L. Garelja et al.

Summary: The development of drugs targeting the CGRP system has been a major breakthrough in migraine management. These drugs can be classified into antibodies and receptor antagonists, with receptor antagonists further divided into small molecule antagonists and antibody antagonists. While antagonists are most potent at the CGRP receptor, they may also show antagonism at the AMY(1) receptor, indicating the need for further research.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

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Article Pharmacology & Pharmacy

Pharmacological characterisation of mouse calcitonin and calcitonin receptor-like receptors reveals differences compared with human receptors

Michael L. Garelja et al.

Summary: The pharmacology of the mouse CLR/CTR and RAMPs receptors differs from that of humans, with mouse receptors showing reduced discrimination between ligands, posing challenges for interpreting data in preclinical models and translating findings from mice to humans. New ligands are needed to differentiate between these complexes.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes

Andrew D. Cansfield et al.

Summary: This study describes a series of macrocyclic calcitonin gene-related peptide (CGRP) receptor antagonists identified using structure-based design principles, exemplified by HTL0028016 and HTL0028125. The structural characterization of the interaction between two of the macrocycle antagonists and the CGRP receptor ectodomain using X-ray crystallography is presented, along with the structure-activity relationships associated with point changes to the macrocyclic antagonists. The identification of non-peptidic/natural product-derived, macrocyclic ligands for a G protein coupled receptor (GPCR) is noteworthy.

ACS CHEMICAL NEUROSCIENCE (2022)

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Article Clinical Neurology

Activation of the trigeminal system as a likely target of SARS-CoV-2 may contribute to anosmia in COVID-19

Karl Messlinger et al.

Summary: Clinical publications consistently show that headache is a common and debilitating symptom in patients with COVID-19, often exhibiting migraine-like characteristics. Studies suggest that activation of the trigeminal nerve may contribute to both headache and anosmia in COVID-19 patients.

CEPHALALGIA (2022)

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Article Clinical Neurology

Rapid resolution of migraine symptoms after initiating the preventive treatment eptinezumab during a migraine attack: results from the randomized RELIEF trial

Jessica Ailani et al.

Summary: Eptinezumab administered during a migraine attack resulted in early separation from placebo in terms of headache pain freedom/relief, absence of most bothersome symptom, absence of photophobia, phonophobia, and nausea. This suggests a potential peripheral pharmacological action for CGRP blockade.

BMC NEUROLOGY (2022)

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Article Clinical Neurology

The monoclonal CGRP-receptor blocking antibody erenumab has different effects on brainstem and cortical sensory-evoked responses

Francesco Casillo et al.

Summary: This study found that erenumab, in addition to its known peripheral effects, can induce central effects in the brainstem and later in the cortex. These results may be due to a direct effect on the central nervous system or an indirect effect secondary to peripheral drug modulation.

CEPHALALGIA (2022)

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Article Clinical Neurology

Calcitonin receptor antibody validation and expression in the rodent brain

Erica R. Hendrikse et al.

Summary: This study examined the expression of the calcitonin receptor protein subunit in the rodent brain and found that it was present in several brain regions relevant to migraine. The findings suggest a potential link between the calcitonin gene-related peptide and migraine, but further research is needed to understand the functional consequences of calcitonin receptor expression.

CEPHALALGIA (2022)

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Article Cell Biology

Excess neuropeptides in lung signal through endothelial cells to impair gas exchange

Jinhao Xu et al.

Summary: Excess neuropeptides derived from pulmonary neuroendocrine cells contribute to pulmonary manifestations including hypoxemia by affecting endothelial cell function, leading to lung fluid accumulation. Restricting neuropeptide function may improve fluid accumulation and gas exchange in these conditions.

DEVELOPMENTAL CELL (2022)

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Review Pharmacology & Pharmacy

Small molecule CGRP receptor antagonists for the preventive treatment of migraine: A review

Jessica Barreto Ribeiro dos Santos et al.

Summary: This article reviews the chemistry, pharmacodynamics, pharmacokinetics, efficacy, safety, and tolerability profile of small molecule CGRP receptor antagonists for the preventive treatment of migraine. The study finds that atogepant and rimegepant are effective and safe for the preventive treatment of migraine in adults.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Review Clinical Neurology

The use of erenumab for migraine prophylaxis during pregnancy: A case report and narrative review

Sierra J. Vig et al.

Summary: This article reports a case of a woman who continued to use erenumab for migraine prophylaxis during pregnancy and reviews the limited pregnancy safety data for CGRP receptor and ligand-directed therapies approved for migraine prophylaxis. The findings highlight the lack of safety data regarding the use of these agents during pregnancy, despite their frequent use in women of childbearing potential.

HEADACHE (2022)

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Article Cardiac & Cardiovascular Systems

Myocardial perfusion recovery induced by an α-calcitonin gene-related peptide analogue

Simon Bentsen et al.

Summary: The study found that the CGRP analogue, SAX, has a cardioprotective effect in a rat model of myocardial infarction, improving myocardial perfusion recovery after chronic occlusion of the coronary artery.

JOURNAL OF NUCLEAR CARDIOLOGY (2022)

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Article Chemistry, Medicinal

Pharmacological, Pharmacokinetic, Pharmacodynamic and Physicochemical Characterization of FE 205030: A Potent, Fast Acting, Injectable CGRP Receptor Antagonist for the Treatment of Acute Episodic Migraine

Karthik Srinivasan et al.

Summary: The peptidic CGRP antagonist FE 205030 is a selective and potent drug with fast onset of action and optimal half-life. It has shown good antagonist activity in animal experiments and human vascular relaxation studies. Dose determination using allometric scaling and modeling indicates the appropriate dosage for patients. It also possesses suitable physicochemical properties for convenient administration.

JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Changes in dorsal root ganglion CGRP expression in mouse pinch nerve injury model: Modulation by Somatostatin type-2 receptor

Qiong Xiang et al.

Summary: This study found that antagonizing SSTR2 can inhibit CGRP expression and aggravate painful behavior in a model of compressed sciatic nerve injury. This provides important clues for understanding the pain mechanism and demonstrates the importance of CGRP in pain behavior.

JOURNAL OF CHEMICAL NEUROANATOMY (2022)

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Article Clinical Neurology

Calcitonin gene-related peptide-targeting drugs and Raynaud's phenomenon: a real-world potential safety signal from the WHO pharmacovigilance database

Alexandre O. Gerard et al.

Summary: This study found a significant association between CGRP-targeting drugs and Raynaud's phenomenon, with a stronger association compared to other drugs. However, caution is needed in the use of CGRP-targeting drugs due to limitations such as missing data and reporting bias.

JOURNAL OF HEADACHE AND PAIN (2022)

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Article Clinical Neurology

Characterization of erenumab and rimegepant on calcitonin gene-related peptide induced responses in Xenopus Laevis oocytes expressing the calcitonin gene-related peptide receptor and the amylin-1 receptor

Sanne Hage La Cour et al.

Summary: The use of new CGRP receptor antagonists and monoclonal antibodies targeting CGRP and CGRP-R has provided new treatment options for migraine patients. The study showed that erenumab and rimegepant are potent antagonists of CGRP-R and AMY(1)-R with significantly higher preference for CGRP-R over AMY(1)-R.

JOURNAL OF HEADACHE AND PAIN (2022)

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Editorial Material Clinical Neurology

CGRP-targeted drugs for migraine: still many uncertainties

Hans Christoph Diener

LANCET NEUROLOGY (2022)

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Article Clinical Neurology

Calcitonin gene-related peptide-targeting drugs for migraine: how pharmacology might inform treatment decisions

Linda Al-Hassany et al.

Summary: Migraine is the second most disabling disorder worldwide, and the pharmacology and clinical effects of CGRP-targeted drugs are not fully understood. Factors such as sex, body-mass index, age, and ethnic background may affect the pharmacokinetics of these treatments, particularly Gepants. Patient characteristics may play a more prominent role in the management of migraine as more is learned about CGRP-targeted therapies.

LANCET NEUROLOGY (2022)

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Article Biology

Migraine monoclonal antibodies against CGRP change brain activity depending on ligand or receptor target - an fMRI study

Hauke Basedau et al.

Summary: This study found that treatment with CGRP antibodies had specific effects on brain activation and modulation in migraine patients. Galcanezumab reduced hypothalamic activation in all patients, with a stronger reduction in responders. Comparison between galcanezumab and erenumab showed differences in brain networks activated by the two antibodies. Pre-treatment activity of the spinal trigeminal nucleus and its coupling with the hypothalamus were associated with response to galcanezumab.

ELIFE (2022)

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Article Pharmacology & Pharmacy

Lipidated Calcitonin Gene-Related Peptide (CGRP) Peptide Antagonists Retain CGRP Receptor Activity and Attenuate CGRP Action In Vivo

Aqfan Jamaluddin et al.

Summary: This study explores the feasibility of developing lipidated CGRP peptide antagonists and demonstrates that selected lipidated peptide antagonists can retain potent antagonist activity at the CGRP receptor and inhibit endogenous CGRP action in vivo.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Physiology

The Neuropeptide α-Calcitonin Gene-Related Peptide as the Mediator of Beneficial Effects of Exercise in the Cardiovascular System

Tom Skaria et al.

Summary: Regular physical activity has cardiovascular protective effects and increases the concentration of alpha-calcitonin gene-related peptide (alpha CGRP). Alpha CGRP plays a role in vasodilation and migraine. Mouse models suggest that loss of alpha CGRP disrupts the cardiovascular system's adaptation to exercise and worsens cardiovascular damage in chronic hypertension, which can be reversed by alpha CGRP administration. This suggests that alpha CGRP agonists may be a therapeutic option for cardiovascular protection when exercise is not possible or contraindicated. However, the long-term cardiovascular safety of anti-CGRP therapy in individuals with cardiovascular diseases is still uncertain.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Physiology

CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons

Tayla A. Rees et al.

Summary: This study identified the relative distributions of the AMY(1) receptor subunit, CTR, and CGRP in neurons or glia in the trigeminal ganglia of rats, mice, and humans. It was found that CTR and CGRP were primarily colocalized in small to medium sized neurons, suggesting a role for CTR-based receptor activation during migraine. The results suggest that targeting the trigeminal ganglia CTR-based receptor could be a potential treatment for craniofacial pain and migraine.

FRONTIERS IN PHYSIOLOGY (2022)

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Review Physiology

The Vascular-Dependent and -Independent Actions of Calcitonin Gene-Related Peptide in Cardiovascular Disease

Fulye Argunhan et al.

Summary: The treatment of hypertension and heart failure is a major challenge, with over 26 million people affected worldwide. CGRP has been found to have beneficial effects in hypertensive and heart failure patients. However, due to its short half-life, the beneficial effects of CGRP are often acute and transient. Recently developed long-lasting CGRP agonists may provide a solution for further studying CGRP in cardiovascular disease.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Medicine, General & Internal

New Generation Gepants: Migraine Acute and Preventive Medications

David Moreno-Ajona et al.

Summary: Migraine is a debilitating disease and new treatment options are necessary due to the issues with existing medications. The latest generation of CGRP pathway-targeting drugs have shown efficacy, safety, and tolerability in clinical trials. This article reviews the clinical trials of existing and new drugs.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Chemistry, Multidisciplinary

Probing Neuropeptide Volume Transmission In Vivo by Simultaneous Near-Infrared Light-Triggered Release and Optical Sensing

Hejian Xiong et al.

Summary: In this study, an integrated optical approach using Plasmonic nAnovesicles and cell-based neurotransmitter fluorescent engineered reporter (CNiFER), called PACE, was developed to investigate neuropeptide signaling in the mouse neocortex. The results show that neuropeptide transmission is reduced but synchronized within 130 μm and smaller and delayed at longer distances.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Review Clinical Neurology

Is calcitonin gene-related peptide a reliable biochemical marker of migraine?

Betel Tesfay et al.

Summary: The purpose of this study was to provide an overview of clinical studies on CGRP measurements in body fluids of migraine patients and to discuss the validity of CGRP measurement as a clinical biomarker of migraine. Several studies have reported increased CGRP levels in various body fluids of migraine patients, suggesting that CGRP may be a feasible biomarker. However, inconsistencies and methodological challenges in measuring CGRP levels exist. CGRP measurements may have potential as biomarkers for predicting response to migraine therapy.

CURRENT OPINION IN NEUROLOGY (2022)

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Article Clinical Neurology

Characterization of transit rates in the large intestine of mice following treatment with a CGRP antibody, CGRP receptor antibody, and small molecule CGRP receptor antagonists

Kirk W. Johnson et al.

Summary: This study characterizes the effects of blocking calcitonin gene-related peptide (CGRP) activity on gastrointestinal transport. The results suggest that selectively blocking the CGRP receptor may have a greater impact on gastrointestinal transit than attenuating the activity of the ligand CGRP, possibly due to physiologically opposing mechanisms between CGRP and AMY1 receptors.

HEADACHE (2022)

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Letter Clinical Neurology

Editors' Note: Effect of Levetiracetam Use Duration on Overall Survival of Isocitrate Dehydrogenase Wild-Type Glioblastoma in Adults: An Observational Study

Aravind Ganesh et al.

NEUROLOGY (2022)

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Article Neurosciences

Sex Differences in CGRP Regulation and Function in the Amygdala in a Rat Model of Neuropathic Pain

Peyton Presto et al.

Summary: The amygdala plays a crucial role in the emotional response to pain and pain modulation. The lateral and capsular regions of the central nucleus of the amygdala are important areas for processing pain-related information. The CGRP1 receptor is involved in neuropathic pain-related amygdala activity, with a more significant impact on females.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

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Article Biochemistry & Molecular Biology

Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection

Daping Yang et al.

Summary: Neuroepithelial crosstalk plays a critical role in gut physiology, particularly in mediating gut barrier protection. Sensory neurons communicate with intestinal goblet cells to promote mucus secretion and gut protection via the CGRP-Ramp1 pathway. Additionally, commensal microbes can activate nociceptors to regulate CGRP release.

CELL (2022)

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Article Neurosciences

From spreading depolarization to epilepsy with neuroinflammation: The role of CGRP in cortex

Fatima Gimeno-Ferrer et al.

Summary: CGRP release plays a major role in migraine pain by activating the trigeminal pain pathways. This study explores additional effects of CGRP on cortical circuits and investigates its impact on cortical excitability, cortical spreading depolarization (CSD), blood-brain-barrier (BBB), and microglial morphology.

EXPERIMENTAL NEUROLOGY (2022)

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Article Clinical Neurology

A phase IV clinical trial of gastrointestinal motility in adult patients with migraine before and after initiation of a calcitonin gene-related peptide ligand (galcanezumab) or receptor (erenumab) antagonist

David Kudrow et al.

Summary: This study compares the effects of different initial doses of CGRP monoclonal antibodies on gastrointestinal motility in patients with migraine and suggests potential mechanistic differences.

HEADACHE (2022)

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Article Clinical Neurology

Anti-nociceptive effects of dual neuropeptide antagonist therapy in mouse model of neuropathic and inflammatory pain

Min Su Kim et al.

Summary: The study found that the combination therapy of CGRP antagonist and NK1 antagonist is more effective in alleviating neuropathic or inflammatory pain. The dual treatment significantly reduced pain behaviors, improved anxiety-related behaviors, and demonstrated a meaningful additive effect in animal models.

KOREAN JOURNAL OF PAIN (2022)

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Article Biology

New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis

Helene Choquet et al.

Summary: Helene Choquet et al. identified novel loci associated with migraine in a large multiethnic genome-wide meta-analysis. They found 79 loci associated with migraine, including 45 which have not been previously reported and 3 that were specific to women, and which may lead to an improved understanding of migraine etiology.

COMMUNICATIONS BIOLOGY (2021)

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Article Biology

CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells

Ashley J. Clark et al.

Summary: Agonist bias refers to different ligands producing distinct signaling outputs at the same receptor, with physiological consequences demonstrated for the CLR receptor. This study reveals that GPCR agonist bias occurs naturally in human cells and plays a fundamental role in providing unique functions to endogenous agonists, opening up possibilities for further research on RAMP function in native environments.

COMMUNICATIONS BIOLOGY (2021)

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Article Biology

Acute Increase in Blood αCGRP at Maximal Exercise and Its Association to Cardiorespiratory Fitness, Carbohydrate Oxidation and Work Performed: An Exploratory Study in Young Men

Adolfo Aracil-Marco et al.

Summary: The study found that the majority of young men respond to a single maximal exercise bout with an increase in blood alpha-CGRP concentration, and this response is associated with their cardiorespiratory fitness, carbohydrate oxidation, and work performed.

BIOLOGY-BASEL (2021)

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Article Medicine, General & Internal

Raynaud's phenomenon secondary to erenumab in a patient with chronic migraine

Agaath Hedina Manickam et al.

Summary: Raynaud's phenomenon is a rare side effect of CGRP monoclonal antibodies, and patients with a background of Raynaud's phenomenon may experience worsening of their symptoms if started on these treatments in the future.

CLINICAL CASE REPORTS (2021)

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Article Immunology

Nociceptors protect sickle cell disease mice from vaso-occlusive episodes and chronic organ damage

Chunliang Xu et al.

Summary: Sensory nerves play a protective role in SCD, relieving the severity of VOE, and manipulating nociception may provide a promising approach for treating SCD.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Anesthesiology

Different forms of traumatic brain injuries cause different tactile hypersensitivity profiles

Anne-Sophie Wattiez et al.

Summary: The study characterized tactile sensory profiles of two nonpenetrating models of posttraumatic headache (PTH). The results showed that repetitive daily injury for 3 days induced more severe phenotypes, offering new insights into patterns of injury that may place patients at a greater risk of developing PTH. The research also provided preclinical support for a pathophysiologic role of calcitonin gene-related peptide in PTH.

PAIN (2021)

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Editorial Material Biochemistry & Molecular Biology

CGRP Receptor Antagonism in COVID-19: Potential Cardiopulmonary Adverse Effects

Tom Skaria et al.

Summary: The US FDA has authorized a drug repurposing trial using CGRP receptor antagonists to reduce lung inflammation in COVID-19. However, concerns about potential cardiopulmonary adverse effects of antagonizing CGRP have been raised, highlighting the importance of early detection and prevention.

TRENDS IN MOLECULAR MEDICINE (2021)

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Review Dentistry, Oral Surgery & Medicine

Exploring the roles of neuropeptides in trigeminal neuropathic pain: A systematic review and narrative synthesis of animal studies

Nontawat Chuinsiri et al.

Summary: This systematic review focused on changes in neuropeptide expression following trigeminal neuropathic pain in animal models, with CGRP and substance P being the most frequently reported neuropeptides. However, included studies showed varying levels of bias risk, ranging from unclear to high.

ARCHIVES OF ORAL BIOLOGY (2021)

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Article Clinical Neurology

Interictal amylin levels in chronic migraine patients: A case-control study

Pablo Irimia et al.

Summary: The study evaluated interictal concentrations of amylin and calcitonin gene-related peptide in peripheral blood as potential biomarkers for chronic migraine. Higher levels of amylin were found in patients with chronic migraine, suggesting a possible diagnostic biomarker for this condition.

CEPHALALGIA (2021)

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Article Clinical Neurology

Combined onabotulinumtoxinA/atogepant treatment blocks activation/sensitization of high-threshold and wide-dynamic range neurons

Agustin Melo-Carrillo et al.

Summary: The study showed that combined treatment with OnabotulinumtoxinA and atogepant prevented activation and sensitization of trigeminovascular neurons induced by cortical spreading depression, potentially offering more effective relief for chronic migraine patients compared to monotherapy.

CEPHALALGIA (2021)

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Review Neurosciences

Was it something I ate? Understanding the bidirectional interaction of migraine and appetite neural circuits

Margarida Martins-Oliveira et al.

Summary: Studies have shown that migraine attacks may be related to changes in appetite, with fasting or skipping meals often considered common triggers in susceptible individuals, and hunger or abnormal appetite reported in the premonitory phase. Over the past decade, research into overlapping fields of neuroscience has become increasingly important, leading to novel findings. Data suggest that further research is needed to uncover the key neurobiological mechanisms underlying the interaction between migraine and appetite.

BRAIN RESEARCH (2021)

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Article Clinical Neurology

Hypertension: A new safety risk for patients treated with erenumab

Suprat Saely et al.

Summary: This study analyzed 61 postmarketing case reports of elevated blood pressure associated with erenumab use, with most cases occurring in women within a week of initial dose. Some cases had serious outcomes, including hospitalization, but there were no reported deaths.

HEADACHE (2021)

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Article Multidisciplinary Sciences

Nociceptive nerves regulate haematopoietic stem cell mobilization

Xin Gao et al.

Summary: Nociceptive nerves play a role in enforcing HSC mobilization through CGRP secretion, collaborating with sympathetic nerves to maintain HSCs in the bone marrow. CGRP directly activates HSCs via the G alpha(s)/adenylyl cyclase/cAMP pathway, and consumption of capsaicin-containing food enhances HSC mobilization in mice.

NATURE (2021)

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Article Neurosciences

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

Jenny Meinhardt et al.

Summary: The study demonstrates the presence of SARS-CoV-2 in the nasopharynx and brain, suggesting the virus may enter the CNS through the olfactory mucosa. The virus utilizes the neural-mucosal interface in the olfactory mucosa to penetrate the nervous system, affecting various neuroanatomical areas, including the primary respiratory and cardiovascular control center.

NATURE NEUROSCIENCE (2021)

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Editorial Material Clinical Neurology

Making headway - a role for CGRP in post-traumatic headache

Dimos D. Mitsikostas et al.

Summary: Post-traumatic headache, while common, is still not well understood and managed effectively. Recent research has found a link between calcitonin gene-related peptide and the trigeminovascular system, opening up new possibilities for understanding the pathophysiology and improving treatment outcomes for this disorder.

NATURE REVIEWS NEUROLOGY (2021)

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Article Clinical Neurology

Early outcomes of migraine after erenumab discontinuation: data from a real-life setting

Eleonora De Matteis et al.

Summary: The study evaluated early outcomes of erenumab discontinuation in migraine patients who had a continuous positive response. Results showed that most patients experienced worsening symptoms in the first 4 weeks after treatment cessation, although still lower than baseline. More than half of the patients had an early disease worsening, while others maintained their responder status after treatment completion. Further studies are needed to identify predictors of prolonged response to erenumab and determine the optimal treatment duration based on patients' characteristics.

NEUROLOGICAL SCIENCES (2021)

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Article Neurosciences

Area Postrema Cell Types that Mediate Nausea-Associated Behaviors

Chuchu Zhang et al.

Summary: By constructing an area postrema cell atlas and utilizing cell-specific manipulation, the basic organization of the area postrema nausea circuitry has been revealed, providing a framework for further exploration of nausea mechanisms.

NEURON (2021)

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Article Anesthesiology

Increase in trigeminal ganglion neurons that respond to both calcitonin gene-related peptide and pituitary adenylate cyclase-activating polypeptide in mouse models of chronic migraine and posttraumatic headache

Zhaohua Guo et al.

Summary: Studies suggest that blocking both CGRP and PACAP signaling pathways in TG neurons may be more effective in treating chronic migraine and posttraumatic headache than targeting individual pathways.

PAIN (2021)

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Editorial Material Clinical Neurology

Inflammation in migraine ... or not ... : A critical evaluation of the evidence

Andrew Charles et al.

HEADACHE (2021)

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Article Clinical Neurology

Risk of hypertension in erenumab-treated patients with migraine: Analyses of clinical trial and postmarketing data

David W. Dodick et al.

Summary: Clinical trials did not show an increased risk of hypertension with erenumab compared to placebo. Adverse event rates of hypertension reported with erenumab in the postmarketing setting were generally low. Additional data are needed to fully understand the risk of hypertension associated with erenumab.

HEADACHE (2021)

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Article Multidisciplinary Sciences

Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells

Manjunatha Shivaraju et al.

Summary: Recent research has shown that airway basal stem cells have the ability to sense hypoxia and differentiate into solitary NE cells, which secrete a protective peptide called CGRP to mitigate hypoxic injury. This mechanism helps to explain the role of NE cells in the respiratory system and their response to environmental stimuli.

SCIENCE (2021)

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Article Biochemistry & Molecular Biology

miR-34a-5p up-regulates the IL-1β/COX2/PGE2 inflammation pathway and induces the release of CGRP via inhibition of SIRT1 in rat trigeminal ganglion neurons

Hui Zhang et al.

Summary: Studies have shown that miR-34a-5p can up-regulate the IL-1 beta/COX2/PGE2 inflammation pathway, induce apoptosis, enhance CGRP release, and thereby affect the pathogenesis of migraines.

FEBS OPEN BIO (2021)

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Article Clinical Neurology

Discontinuing monoclonal antibodies targeting CGRP pathway after one-year treatment: an observational longitudinal cohort study

Fabrizio Vernieri et al.

Summary: The study aimed to evaluate the effect of discontinuing mAbs anti-CGRP on migraine patients. Results showed that migraine frequency and disability gradually increased after stopping the treatment, but most patients did not relapse to medication overuse or chronic migraine.

JOURNAL OF HEADACHE AND PAIN (2021)

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Article Clinical Neurology

Inflammatory complications of CGRP monoclonal antibodies: a case series

Jason C. Ray et al.

Summary: This case series offers insights into the potential molecular mechanisms and side effects of CGRP antagonism in migraine, emphasizing the need for clinical vigilance in patient care moving forward.

JOURNAL OF HEADACHE AND PAIN (2021)

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Article Physiology

Amylin antibodies frequently display cross-reactivity with CGRP: characterization of eight amylin antibodies

Tayla A. Rees et al.

Summary: This study found that current amylin antibodies frequently cross-react with CGRP, making them unsuitable for use in tissues that highly express CGRP. Therefore, previous studies using these antibodies should be reevaluated in light of these findings.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2021)

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Article Pharmacology & Pharmacy

A Monoclonal Anti-Calcitonin Gene-Related Peptide Antibody Decreases Stress-Induced Colonic Hypersensitivity

Ehsan Noor-Mohammadi et al.

Summary: The study demonstrated that inhibiting peripheral CGRP signaling could reverse colonic hypersensitivity induced by chronic adult stress or early life stress. Inhibition of peripheral CGRP signaling reduced central sensitization and alleviated stress-induced visceral pain.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2021)

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Article Clinical Neurology

Migraine therapeutics differentially modulate the CGRP pathway

Minoti Bhakta et al.

Summary: Therapeutic agents targeting the CGRP pathway play a key role in migraine treatment, but different drugs may have distinct mechanisms of action. Research findings suggest that therapeutics targeting CGRP ligands and receptors may differ in function and internalization.

CEPHALALGIA (2021)

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Article Clinical Neurology

CGRP monoclonal antibody prevents the loss of diffuse noxious inhibitory controls (DNIC) in a mouse model of post-traumatic headache

Caroline M. Kopruszinski et al.

Summary: The study aimed to investigate the role of calcitonin-gene related peptide in promoting post-traumatic headache and dysregulation of central pain modulation induced by mild traumatic brain injury in mice. The results showed that mild traumatic brain injury led to cutaneous allodynia and loss of diffuse noxious inhibitory control in mice on day 2 post-injury. However, systemic treatment with fremanezumab was able to block mild traumatic brain injury-induced cutaneous allodynia and restore the loss of diffuse noxious inhibitory control.

CEPHALALGIA (2021)

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Article Clinical Neurology

Real-world efficacy, tolerability, and safety of ubrogepant

Chia-Chun Chiang et al.

Summary: This study evaluated the real-world efficacy, tolerability, and safety of ubrogepant in a tertiary headache center. Results showed that a significant proportion of patients experienced headache relief and complete headache freedom after taking ubrogepant, with a high rate of satisfaction. Adverse events, particularly fatigue, were reported in a substantial number of patients, emphasizing the importance of monitoring side effects in clinical practice. Further research is needed to confirm these findings and explore the long-term efficacy and safety of ubrogepant.

HEADACHE (2021)

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Article Neurosciences

Convergence of peptidergic and non-peptidergic protein markers in the human dorsal root ganglion and spinal dorsal horn

Stephanie Shiers et al.

Summary: The study found that most nociceptors in humans express multiple markers and exhibit differences in central projection patterns compared to mice. Understanding how human nociceptors connect to subsets of dorsal horn neurons is crucial for understanding the physiological consequences of species differences.

JOURNAL OF COMPARATIVE NEUROLOGY (2021)

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Article Anesthesiology

Delta opioid receptor regulation of calcitonin gene-related peptide dynamics in the trigeminal complex

Laura S. Moye et al.

Summary: DOP agonists show promise in alleviating chronic migraine-associated pain by modulating CGRP release and blocking CGRPR signaling. Coexpression of DOP with CGRP and its receptor components was observed in the trigeminal system, suggesting a potential mechanism of action for migraine treatment.

PAIN (2021)

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Article Anesthesiology

Efficacy and Tolerability of Calcitonin Gene-Related Peptide-Targeted Monoclonal Antibody Medications as Add-on Therapy to OnabotulinumtoxinA in Patients with Chronic Migraine

Fred Cohen et al.

Summary: The study demonstrated that adding CGRP-targeted mAb to onabot treatment in patients with chronic migraine resulted in further reductions in headache days, with good overall tolerability.

PAIN MEDICINE (2021)

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Article Multidisciplinary Sciences

GFRAL-expressing neurons suppress food intake via aversive pathways

Paul Sabatini et al.

Summary: GDF-15 activates GFRAL neurons, affecting the expression of neurotransmitters and neuropeptides, thereby inhibiting feeding and gastric emptying, promoting conditioned taste aversion; neurons with the strongest effect innervate the PBN and target CGRP(PBN) neurons, silencing of which abolishes the negative and anorectic effects of GDF-15.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Multidisciplinary Sciences

Structure and dynamics of the CGRP receptor in apo and peptide-bound forms

Tracy M. Josephs et al.

Summary: This study provides insights into the mechanisms of class B1 GPCR activation by analyzing the structures and protein conformational dynamics of GPCRs.

SCIENCE (2021)

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Article Endocrinology & Metabolism

Sensory neurons expressing calcitonin gene-related peptide a regulate adaptive thermogenesis and diet-induced obesity

Kuldeep Makwana et al.

Summary: The study revealed that genetic ablation of heat-sensing CGRPa neurons promotes resistance to weight gain upon high-fat diet feeding and increases energy expenditure in mice by reducing lipid deposition, enhancing fatty acid oxidation gene expression, and increasing lipolysis in adipocytes, as well as enhancing mitochondrial respiration in iBAT.

MOLECULAR METABOLISM (2021)

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Article Clinical Neurology

Amylin Analog Pramlintide Induces Migraine-like Attacks in Patients

Hashmat Ghanizada et al.

Summary: This study investigated the role of pramlintide in the pathogenesis of migraine, finding that it participates in migraine attacks through activation of the amylin receptor. Through experiments on patients and studies on animal models, it was discovered that pramlintide and CGRP have similar effects in inducing migraine-like symptoms.

ANNALS OF NEUROLOGY (2021)

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Article Neurosciences

Transient Receptor Potential Channel 4 Small-Molecule Inhibition Alleviates Migraine-Like Behavior in Mice

Cinder Faith Cohen et al.

Summary: The study revealed the crucial role of TRPC4 in pain and migraine, with the TRPC4 antagonist ML204 showing promising effects in reducing migraine-like behaviors induced by nitroglycerin and lowering CGRP levels in mice. These findings suggest TRPC4 as a potential target for novel clinical treatments for migraineurs.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

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Article Clinical Neurology

Pharmacokinetics and safety of ubrogepant when coadministered with calcitonin gene-related peptide-targeted monoclonal antibody migraine preventives in participants with migraine: A randomized phase 1b drug-drug interaction study

Abhijeet Jakate et al.

Summary: The study evaluated the impact of two CGRP-targeted mAbs, erenumab and galcanezumab, on the PK profile, safety, and tolerability of ubrogepant in adults with migraine. The results showed that coadministration of ubrogepant with erenumab or galcanezumab did not significantly alter the PK profile of ubrogepant and had no safety concerns.

HEADACHE (2021)

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Review Clinical Neurology

A link between gastrointestinal disorders and migraine: Insights into the gut-brain connection

Sheena K. Aurora et al.

Summary: Migraine and gastrointestinal disorders share a common etiology, with delayed gastric emptying, functional dyspepsia, and CVS being associated with migraine and impacting treatment. Recognition of gastrointestinal disorders in migraine patients is important for improving treatment outcomes.

HEADACHE (2021)

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Article Biochemistry & Molecular Biology

Excitatory Effects of Calcitonin Gene-Related Peptide (CGRP) on Superficial Sp5C Neurons in Mouse Medullary Slices

Fang Zheng et al.

Summary: The neuromodulator CGRP increases neuronal activity in the superficial laminae of the spinal trigeminal nucleus caudalis by promoting excitatory synaptic drive and enhancing cell intrinsic properties. These central effects likely contribute to the activation of nociceptive pathways leading to severe headaches such as migraines.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

Effects of Calcitonin-Gene-Related-Peptide on Auditory Nerve Activity

Colleen G. Le Prell et al.

Summary: The study found that endogenous CGRP released by lateral olivocochlear neurons can enhance auditory nerve activity, but the CGRP receptor antagonist does not affect spontaneous or sound-driven auditory nerve activity or OHC function. The results suggest that CGRP acts on neurons rather than outer hair cells.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Letter Clinical Neurology

Do anti-CGRP drugs have a role in migraine aura therapy?

Eleonora Matteo et al.

JOURNAL OF NEUROLOGY (2021)

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Article Neurosciences

PACAP Induces Light Aversion in Mice by an Inheritable Mechanism Independent of CGRP

Adisa Kuburas et al.

Summary: CGRP and PACAP have emerged as mediators of migraine, inducing migraine-like symptoms through independent pathways in mice. Monoclonal antibodies targeting PACAP may be effective in patients unresponsive to CGRP-based therapeutics.

JOURNAL OF NEUROSCIENCE (2021)

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Article Pharmacology & Pharmacy

AM833 is a novel agonist of calcitonin family G protein-coupled receptors: pharmacological comparison to six selective and non-selective agonists

Madeleine M. Fletcher et al.

Summary: The study found that agonists targeting AMYRs may have improved efficacy for treating obesity, with AM833 showing a unique pharmacological profile across receptor binding, activation, and regulation.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2021)

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Review Medicine, General & Internal

Migraine: disease characterisation, biomarkers, and precision medicine

Messoud Ashina et al.

Summary: The paper discusses the progress made in the search for biomarkers of migraine within genetics, provocation modeling, biochemistry, and neuroimaging research. Challenges and future directions for each biomarker modality are outlined, as well as advances in combining and integrating data from multiple biomarker modalities. These efforts contribute to developing precision medicine for future patients with migraine.

LANCET (2021)

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Article Clinical Neurology

Effect of Adrenomedullin on Migraine-Like Attacks in Patients With Migraine A Randomized Crossover Study

Hashmat Ghanizada et al.

Summary: The study confirms that IV infusion of adrenomedullin may trigger migraine attacks, leading to increased headache intensity and changes in physiological indicators such as heart rate and flushing.

NEUROLOGY (2021)

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Article Anesthesiology

Opening of BKCa channels causes migraine attacks: a new downstream target for the treatment of migraine

Mohammad Al-Mahdi Al-Karagholi et al.

Summary: This study found that BKCa channel opening may trigger migraine attacks, and BKCa channel blockers could be potential candidates for novel antimigraine drugs.

PAIN (2021)

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Review Clinical Neurology

Real-World Evidence for Control of Chronic Migraine Patients Receiving CGRP Monoclonal Antibody Therapy Added to OnabotulinumtoxinA: A Retrospective Chart Review

Andrew M. Blumenfeld et al.

Summary: The combination treatment of onabotulinumtoxinA and CGRP mAbs in migraine patients showed significant reduction in headache days, improvement in quality of life, and good tolerability. Further research is needed to explore the potential benefits of this combination therapy.

PAIN AND THERAPY (2021)

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Article Medicine, General & Internal

Evaluation of the Safety of Calcitonin Gene-Related Peptide Antagonists for Migraine Treatment Among Adults With Raynaud Phenomenon

Ilana D. Breen et al.

Summary: The study found that microvascular complications of CGRP antagonist use in patients with underlying RP are uncommon, but caution is still needed when considering the use of these agents in these patients.

JAMA NETWORK OPEN (2021)

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Article Biochemistry & Molecular Biology

To Probe the Binding Interactions between Two FDA Approved Migraine Drugs (Ubrogepant and Rimegepant) and Calcitonin-Gene Related Peptide Receptor (CGRPR) Using Molecular Dynamics Simulations

Lauren Leung et al.

Summary: This study utilized molecular docking and molecular dynamics simulation to investigate the interactions between ubrogepant and rimegepant, oral drugs for migraines, with the related receptor at a molecular level, revealing their binding mechanisms. The results showed that olcegepant has the strongest binding affinity to CGRPR, followed by ubrogepant and rimegepant, mainly due to changes in hydrophobic and electrostatic interactions.

ACS CHEMICAL NEUROSCIENCE (2021)

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Letter Clinical Neurology

Response to letter to the Editor: Assessing migraine therapeutics

Kimberly D. Mackenzie et al.

CEPHALALGIA (2021)

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Letter Clinical Neurology

Assessing migraine therapeutics

Cen Xu et al.

CEPHALALGIA (2021)

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Article Clinical Neurology

CGRP measurements in human plasma - a methodological study

Karl Messlinger et al.

Summary: Calcitonin gene-related peptide plasma levels can be accurately measured using enzyme-linked immunosorbent assay with proper modifications and precautions. Individuals show significant variations in plasma levels, making longitudinal studies suitable for monitoring changes over time.

CEPHALALGIA (2021)

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Article Pharmacology & Pharmacy

Safety and tolerability evaluation of erenumab for the preventive treatment of migraine

Christina Deligianni et al.

Summary: This review found no safety and tolerability concerns related to the use of erenumab in migraine treatment. The most common adverse events were local skin reactions and constipation, but there were no severe adverse events or frequent events leading to treatment discontinuation. Overall, treatment with erenumab was well tolerated.

EXPERT OPINION ON DRUG SAFETY (2021)

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Article Clinical Neurology

HMGB1, NLRP3, IL-6 and ACE2 levels are elevated in COVID-19 with headache: a window to the infection-related headache mechanism

Hayrunnisa Bolay et al.

Summary: This study investigated the relationship between headache and circulating inflammatory molecules in COVID-19 patients. Results showed significantly elevated levels of HMGB1, NLRP3, ACE2, and IL-6 in the serum of patients with headache, indicating a stronger inflammatory response associated with headache. Additionally, COVID-19 patients with headache exhibited specific clinical characteristics such as increased frequency of pulmonary involvement and higher D-dimer levels.

JOURNAL OF HEADACHE AND PAIN (2021)

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Review Clinical Neurology

Role of CGRP pathway polymorphisms in migraine: a systematic review and impact on CGRP mAbs migraine therapy

Damiana Scuteri et al.

Summary: Research interest in the genetic polymorphisms and epigenetics related to migraine, particularly focusing on the calcitonin-gene related peptide (CGRP) pathway, has been increasing. However, only a limited number of studies have been able to identify specific genetic variants affecting migraine susceptibility and treatment response, indicating the need for further well-powered and high-quality research in this area.

JOURNAL OF HEADACHE AND PAIN (2021)

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Article Clinical Neurology

CGRP outflow into jugular blood and cerebrospinal fluid and permeance for CGRP of rat dura mater

Miriam Risch et al.

Summary: The study found that only a small fraction of CGRP applied to the dura mater reaches the jugular blood and, in a delayed manner, also appears in the CSF. The dura mater may act as a barrier for CGRP, limiting its diffusion into the CSF of the subarachnoid space where the concentration is too low to cause vasodilation.

JOURNAL OF HEADACHE AND PAIN (2021)

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Review Clinical Neurology

Migraine and neuroinflammation: the inflammasome perspective

Oguzhan Kursun et al.

Summary: Neuroinflammatory pathways, especially those involving inflammasome proteins, show promise as potential treatment targets and even biomarkers in migraine. The activation of inflammasomes can stimulate trigeminal neurons and contribute to the generation of migraine pain, making them an important focus in migraine research. The NLRP3 inflammasome, in particular, is well-studied and has been implicated in various inflammatory pain conditions, including migraine.

JOURNAL OF HEADACHE AND PAIN (2021)

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Article Clinical Neurology

Cytokine and interleukin profile in patients with headache and COVID-19: A pilot, CASE-control, study on 104 patients

Javier Trigo et al.

Summary: The study aimed to compare cytokine and interleukin profiles in hospitalized COVID-19 patients with and without headache. Patients with headache were younger and more likely to have fever and anosmia. Higher levels of IL-10 were found in patients with headache, reflecting a more intense immune response.

JOURNAL OF HEADACHE AND PAIN (2021)

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Article Neurosciences

Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges

David Schafflick et al.

Summary: Recent findings suggest that CNS-associated border tissues have complex immunological functions, with the dura mater containing a large population of B cells that exhibit long-term tissue residency and maturation in experimental neuroinflammation. This identifies the dura as an unexpected site of B cell residence and potentially of development in both homeostasis and neuroinflammation.

NATURE NEUROSCIENCE (2021)

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Review Clinical Neurology

Hormonal influences in migraine - interactions of oestrogen, oxytocin and CGRP

Diana N. Krause et al.

Summary: Reproductive hormones influence migraine in women but the basis of these effects is unknown. In this Review, the authors discuss what is known about sex hormones and their receptors in migraine-related areas of the CNS and the trigeminovascular pathway and propose a simple model to explain how hormones influence menstrual migraine.

NATURE REVIEWS NEUROLOGY (2021)

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Article Medicine, General & Internal

Atogepant for the Preventive Treatment of Migraine

Jessica Ailani et al.

Summary: Oral atogepant once daily was effective in reducing the number of migraine days and headache days over a period of 12 weeks, but may cause adverse events such as constipation and nausea. Longer and larger trials are needed to determine the effect and safety of atogepant for migraine prevention.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Biology

Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity

Line S. Loken et al.

Summary: CGRP interneurons are under tonic inhibitory control in resting conditions, but become hyperexcitable in response to specific stimuli. They can participate in ascending circuits or reflex circuits to transmit pain information under certain conditions.

ELIFE (2021)

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Review Behavioral Sciences

Mammalian Neuronal mRNA Transport Complexes: The Few Knowns and the Many Unknowns

Elsa C. Rodrigues et al.

Summary: The article discusses how mRNA is sorted into different packages and coupled to motor proteins for transport. It remains unclear whether all mRNAs are transported by the same machinery, or if different adaptors or motors are used for different transcripts. While there is indirect evidence for the involvement of proteins in mRNA localization, relatively little is known about the essential activities required for the actual transport process.

FRONTIERS IN INTEGRATIVE NEUROSCIENCE (2021)

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Article Clinical Neurology

Efficacy of Erenumab in the Treatment of Trigeminal Neuralgia A Retrospective Case Series

Eliot Parascandolo et al.

Summary: This study demonstrates that Erenumab may be an effective treatment option for patients with refractory TN, with improvements in pain, headache frequency, and mood reported by the majority of patients. The treatment was well tolerated with minimal side effects.

NEUROLOGY-CLINICAL PRACTICE (2021)

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Article Medicine, General & Internal

Headaches associated with acute SARS-CoV-2 infection: A prospective cross-sectional study

Delon D. Souza et al.

Summary: Headaches are a common and early symptom of acute SARS-CoV-2 infection, more frequently seen in young females and in those with a history of primary headache disorders. Inflammatory markers levels were lower in those with headaches, indicating that the headaches may be due to local spread of the virus through the trigeminal nerve endings.

SAGE OPEN MEDICINE (2021)

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Article Medicine, General & Internal

Differential Synovial CGRP/RAMP1 Expression in Men and Women With Knee OsteoarthritisYoshihisa

Kentaro Uchida et al.

Summary: Female patients with KOA have higher synovial expression levels of CGRP and RAMP1 compared to males, with CGRP expression positively correlated with pain severity in females but not in males. RAMP1 expression is not correlated with pain severity in either gender. This suggests the presence of different pain mechanisms in men and women with KOA.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Article Clinical Neurology

Effect of Adrenomedullin on Migraine-Like Attacks in Patients With Migraine

Hashmat Ghanizada et al.

Summary: The IV infusion of adrenomedullin was found to increase the incidence and intensity of migraine attacks, as well as significant adverse effects on heart rate and flushing. The study suggests that adrenomedullin may be a potential therapeutic target for migraine treatment.

NEUROLOGY (2021)

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Article Endocrinology & Metabolism

Tolerability of eptinezumab in overweight, obese or type 1 diabetes patients

Brian Baker et al.

Summary: Eptinezumab was well tolerated and did not lead to adverse metabolic effects in overweight/obese patients or those with T1D. There were no significant differences in basal metabolic rate and insulin sensitivity between the eptinezumab and placebo groups in the two studies.

ENDOCRINOLOGY DIABETES & METABOLISM (2021)

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Review Clinical Neurology

A Bidirectional View of Migraine and Diet Relationship

Parisa Gazerani

Summary: Researchers have found that lifestyle and dietary factors play a crucial role in triggering migraines, and making changes in lifestyle and dietary habits can be beneficial in alleviating migraine symptoms. Dietary factors have a significant impact on migraines, with a focus on content and quality of diet, but the specific causal relationship between diet and migraines is still not clearly established.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2021)

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Review Neurosciences

Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain

Amelia J. McFarland et al.

Summary: COVID-19 infection interacts with the peripheral nervous system to induce pain through multiple potential mechanisms, including direct and indirect effects on neuronal excitability to promote and worsen pain states.

PAIN REPORTS (2021)

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Article Cardiac & Cardiovascular Systems

CGRP derived from cardiac fibroblasts is an endogenous suppressor of cardiac fibrosis

Wenqun Li et al.

CARDIOVASCULAR RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors

Sarah J. Routledge et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2020)

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Article Biochemistry & Molecular Biology

Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense

Nicole Y. Lai et al.

CELL (2020)

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Article Clinical Neurology

Contribution of intraganglionic CGRP to migraine-like responses in male and female rats

Erika Ivanna Araya et al.

CEPHALALGIA (2020)

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Article Clinical Neurology

Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier

Rodrigo Noseda et al.

CEPHALALGIA (2020)

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Article Clinical Neurology

Phase 3 randomized, placebo-controlled study of galcanezumab in patients with chronic cluster headache: Results from 3-month double-blind treatment

David W. Dodick et al.

CEPHALALGIA (2020)

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Article Clinical Neurology

Enhanced post-traumatic headache-like behaviors and diminished contribution of peripheral CGRP in female rats following a mild closed head injury

Dara Bree et al.

CEPHALALGIA (2020)

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Article Pharmacology & Pharmacy

CGRP in rat mesenteric artery and vein - receptor expression, CGRP presence and potential roles

Thi Lisa Le et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Review Clinical Neurology

Gut-brain Axis and migraine headache: a comprehensive review

Mahsa Arzani et al.

JOURNAL OF HEADACHE AND PAIN (2020)

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Article Biochemistry & Molecular Biology

Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion

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JOURNAL OF MOLECULAR NEUROSCIENCE (2020)

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Review Clinical Neurology

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Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene-Related Peptide Receptor

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Potential for treatment benefit of small molecule CGRP receptor antagonist plus monoclonal antibody in migraine therapy

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NEUROLOGY (2020)

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Lasmiditan inhibits calcitonin gene-related peptide release in the rodent trigeminovascular system

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Low-dose interleukin-2 reverses behavioral sensitization in multiple mouse models of headache disorders

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Neuropeptides in gut-brain axis and their influence on host immunity and stress

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Amylin/Calcitonin Receptor-Mediated Signaling in POMC Neurons Influences Energy Balance and Locomotor Activity in Chow-Fed Male Mice

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The effects of CGRP in vascular tissue - Classical vasodilation, shadowed effects and systemic dilemmas

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Palatable food access impacts expression of amylin receptor components in the mesocorticolimbic system

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Two-Hour CGRP Infusion Causes Gastrointestinal Hyperactivity: Possible Relevance for CGRP Antibody Treatment

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Editorial Material Clinical Neurology

Could CGRP Antagonists Be Helpful in the Fight Against COVID-19?

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Serotonin and Neuropeptides in Blood From Episodic and Chronic Migraine and Cluster Headache Patients in Case-Control and Case-Crossover Settings: A Systematic Review and Meta-Analysis

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Dual Therapy With Anti-CGRP Monoclonal Antibodies and Botulinum Toxin for Migraine Prevention: Is There a Rationale?

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Cortical potentiation induced by calcitonin gene-related peptide (CGRP) in the insular cortex of adult mice

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The Effect of Adding Calcitonin Gene-Related Peptide Monoclonal Antibodies to Onabotulinum Toxin A Therapy on Headache Burden: A Retrospective Observational Case Series

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Stimulation of Posterior Thalamic Nuclei Induces Photophobic Behavior in Mice

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Increased severity of closed head injury or repetitive subconcussive head impacts enhances post-traumatic headache-like behaviors in a rat model

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Low plasma levels of calcitonin gene-related peptide in persistent post-traumatic headache attributed to mild traumatic brain injury

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Role of Calcitonin Gene-Related Peptide in Nociceptive Modulationin Anterior Cingulate Cortex of Naive Rats and Rats With Inflammatory Pain

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Efficacy, tolerability, and safety of erenumab for the preventive treatment of persistent post-traumatic headache attributed to mild traumatic brain injury: an open-label study

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Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine

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A CGRP receptor antagonist peptide formulated for nasal administration to treat migraine

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Hypersensitivity to Calcitonin Gene-Related Peptide in Post-Traumatic Headache

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Preclinical studies investigating the neural mechanisms involved in the co-morbidity of migraine and temporomandibular disorders: the role of CGRP

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Vascular actions of peripheral CGRP in migraine-like photophobia in mice

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Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization

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Pharmacological treatment of migraine: CGRP and 5-HT beyond the triptans

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Targeting pituitary adenylate cyclase-activating polypeptide (PACAP) with monoclonal antibodies in migraine prevention: a brief review

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Real-World Patient Experience With Erenumab for the Preventive Treatment of Migraine

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Cortical spreading depolarisation-induced facial hyperalgesia, photophobia and hypomotility are ameliorated by sumatriptan and olcegepant

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Plasma levels of CGRP and expression of specific microRNAs in blood cells of episodic and chronic migraine subjects: towards the identification of a panel of peripheral biomarkers of migraine?

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Giving Researchers a Headache - Sex and Gender Differences in Migraine

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Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness

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Induction of calcitonin gene-related peptide expression in rats by cortical spreading depression

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Perivascular neurotransmitters: Regulation of cerebral blood flow and role in primary headaches

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Protease activated receptor 2 (PAR2) activation causes migraine-like pain behaviors in mice

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The role of the brainstem in migraine: Potential brainstem effects of CGRP and CGRP receptor activation in animal models

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Cortical spreading depression as a site of origin for migraine: Role of CGRP

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Current understanding of trigeminal ganglion structure and function in headache

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Calcitonin gene-related peptide potentiated the excitatory transmission and network propagation in the anterior cingulate cortex of adult mice

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PACAP-38 and PACAP(6-38) Degranulate Rat Meningeal Mast Cells via the Orphan MrgB3-Receptor

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Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking

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CSD-Induced Arterial Dilatation and Plasma Protein Extravasation Are Unaffected by Fremanezumab: Implications for CGRP's Role in Migraine with Aura

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Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models

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Opening of ATP-sensitive potassium channels causes migraine attacks: a new target for the treatment of migraine

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Calcitonin gene-related peptide levels in tear fluid are elevated in migraine patients compared to healthy controls

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Raynaud's Phenomenon Associated With Calcitonin Gene-Related Peptide Monoclonal Antibody Antagonists

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Ischemic Stroke Associated With Calcitonin Gene-Related Peptide Inhibitor Therapy for Migraine: A Case Report

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CGRP-dependent and independent mechanisms of acute and persistent post-traumatic headache following mild traumatic brain injury in mice

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The Presence of Calcitonin Gene-Related Peptide and Its Receptors in Rat, Pig and Human Brain: Species Differences in Calcitonin Gene-Related Peptide Pharmacology

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C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system

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Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms

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CURRENT MEDICINAL CHEMISTRY (2019)

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Novel hypotheses emerging from GWAS in migraine?

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An Intraperitoneal Treatment with Calcitonin Gene-Related Peptide (CGRP) Regulates Appetite, Energy Intake/Expenditure, and Metabolism

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Review Pharmacology & Pharmacy

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CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis

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CGRP Is Critical for Hot Flushes in Ovariectomized Mice

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Distribution of CGRP and CGRP receptor components in the rat brain

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CEPHALALGIA (2019)

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CGRP receptor antagonist MK-8825 attenuates cortical spreading depression induced pain behavior

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CEPHALALGIA (2019)

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CGRP-Based Migraine Therapeutics: How Might They Work, Why So Safe, and What Next?

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CURRENT OPINION IN PHYSIOLOGY (2019)

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Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache

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Activation of pial and dural macrophages and dendritic cells by cortical spreading depression

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ANNALS OF NEUROLOGY (2018)

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Pituitary adenylate-cyclase-activating polypeptide (PACAP): another novel target for treatment of primary headaches?

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Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms

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TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice

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BRAIN (2018)

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Transcriptomic profiling of trigeminal nucleus caudalis and spinal cord dorsal horn

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Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition

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Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals

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Effects of Calcitonin Gene-Related Peptide on Colonic Motility and Defecation in Conscious Dogs

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Feasibility of serum CGRP measurement as a biomarker of chronic migraine: a critical reappraisal

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JOURNAL OF HEADACHE AND PAIN (2018)

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Targeted Orexin and Hypothalamic Neuropeptides for Migraine

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NEUROTHERAPEUTICS (2018)

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Glutamate and Its Receptors as Therapeutic Targets for Migraine

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NEUROTHERAPEUTICS (2018)

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Peripherally administered calcitonin gene-related peptide induces spontaneous pain in mice: implications for migraine

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The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm

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JAMA NEUROLOGY (2018)

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Cryo-EM structure of the active, G(s)- protein complexed, human CGRP receptor

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Article Multidisciplinary Sciences

Encoding of danger by parabrachial CGRP neurons

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NATURE (2018)

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Article Orthopedics

CGRP blockade by galcanezumab was not associated with reductions in signs and symptoms of knee osteoarthritis in a randomized clinical trial

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OSTEOARTHRITIS AND CARTILAGE (2018)

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Therapeutic Targeting of Endosomal G-Protein-Coupled Receptors

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TRENDS IN PHARMACOLOGICAL SCIENCES (2018)

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Vascular Contributions to Migraine: Time to Revisit?

Bianca N. Mason et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Loss of α-Calcitonin Gene-Related Peptide (αCGRP) Reduces Otolith Activation Timing Dynamics and Impairs Balance

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FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

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Review Physiology

The Role of Calcitonin Gene Related Peptide (CGRP) in Neurogenic Vasodilation and Its Cardioprotective Effects

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FRONTIERS IN PHYSIOLOGY (2018)

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Migraine induction with calcitonin gene-related peptide in patients from erenumab trials

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JOURNAL OF HEADACHE AND PAIN (2018)

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Parabrachial CGRP Neurons Establish and Sustain Aversive Taste Memories

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NEURON (2018)

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Expression of Pituitary Adenylate Cyclase-activating Peptide, Calcitonin Gene-related Peptide and Headache Targets in the Trigeminal Ganglia of Rats and Humans

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NEUROSCIENCE (2018)

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Article Clinical Neurology

CGRP receptor antagonist activity of olcegepant depends on the signalling pathway measured

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CEPHALALGIA (2018)

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Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin

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ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2018)

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Adrenomedullin 2/intermedin: a putative drug candidate for treatment of cardiometabolic diseases

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BRITISH JOURNAL OF PHARMACOLOGY (2018)

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Co-expression of the calcitonin receptor gene in the hypothalamic kisspeptin neurons in female rats

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REPRODUCTIVE MEDICINE AND BIOLOGY (2018)

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Serum calcitonin gene-related peptide facilitates adipose tissue lipolysis during exercise via PIPLC/IP3 pathways

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ENDOCRINE (2018)

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Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis

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RESPIRATORY RESEARCH (2018)

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Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25

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BRITISH JOURNAL OF PHARMACOLOGY (2018)

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Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysis

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CEPHALALGIA (2017)

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Sex-, stress-, and sympathetic post-ganglionic-dependent changes in identity and proportions of immune cells in the dura

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CEPHALALGIA (2017)

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Integrative concepts of rosacea pathophysiology, clinical presentation and new therapeutics

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EXPERIMENTAL DERMATOLOGY (2017)

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Induction of Migraine-Like Photophobic Behavior in Mice by Both Peripheral and Central CGRP Mechanisms

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JOURNAL OF NEUROSCIENCE (2017)

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Article Endocrinology & Metabolism

Endogenous Calcitonin Gene-Related Peptide Regulates Lipid Metabolism and Energy Homeostasis in Male Mice

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ENDOCRINOLOGY (2017)

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Possible role of calcitonin gene-related peptide in trigeminal modulation of glomerular microcircuits of the rodent olfactory bulb

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EUROPEAN JOURNAL OF NEUROSCIENCE (2017)

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Overview of Neuropeptides: Awakening the Senses?

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HEADACHE (2017)

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Oxytocin and Migraine Headache

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HEADACHE (2017)

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CGRP and Its Receptors

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HEADACHE (2017)

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Genetics of Migraine: Insights into the Molecular Basis of Migraine Disorders

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Neuro-immune interactions in allergic diseases: novel targets for therapeutics

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INTERNATIONAL IMMUNOLOGY (2017)

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Calcitonin gene-related peptide and pain: a systematic review

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JOURNAL OF HEADACHE AND PAIN (2017)

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Blocking CGRP in migraine patients - a review of pros and cons

Marie Deen et al.

JOURNAL OF HEADACHE AND PAIN (2017)

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Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody

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JOURNAL OF NEUROSCIENCE (2017)

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Calcitonin Gene-Related Peptide Induces HIV-1 Proteasomal Degradation in Mucosal Langerhans Cells

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JOURNAL OF VIROLOGY (2017)

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Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach

Michael J. Woolley et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2017)

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Potentiation of NMDA receptor-mediated synaptic transmission at the parabrachial-central amygdala synapses by CGRP in mice

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MOLECULAR PAIN (2017)

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Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus

Carlos A. Campos et al.

NATURE NEUROSCIENCE (2017)

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Review Neurosciences

Functional consequences of neuropeptide and small-molecule co-transmission

Michael P. Nusbaum et al.

NATURE REVIEWS NEUROSCIENCE (2017)

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Anti-CGRP antibodies block CGRP-induced diarrhea in mice

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NEUROPEPTIDES (2017)

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LARGE DENSE-CORE VESICLE EXOCYTOSIS FROM MOUSE DORSAL ROOT GANGLION NEURONS IS REGULATED BY NEUROPEPTIDE Y

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Review Anesthesiology

The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine

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PAIN (2017)

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Differential effects of Calca-derived peptides in male mice with diet-induced obesity

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PLOS ONE (2017)

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GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Determination of stable reference genes for RT-qPCR expression data in mechanistic pain studies on pig dorsal root ganglia and spinal cord

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RESEARCH IN VETERINARY SCIENCE (2017)

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Reflex Modification Audiometry Reveals Dual Roles for Olivocochlear Neurotransmission

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FRONTIERS IN CELLULAR NEUROSCIENCE (2017)

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Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity

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The Molecular Fingerprint of Dorsal Root and Trigeminal Ganglion Neurons

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FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)

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Amylin Acts in the Lateral Dorsal Tegmental Nucleus to Regulate Energy Balance Through Gamma-Aminobutyric Acid Signaling

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BIOLOGICAL PSYCHIATRY (2017)

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Review Endocrinology & Metabolism

Role of calcitonin gene-related peptide in energy metabolism

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ENDOCRINE (2017)

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Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs

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BIOCHEMICAL PHARMACOLOGY (2017)

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Article Cardiac & Cardiovascular Systems

A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure

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CIRCULATION (2017)

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Article Pharmacology & Pharmacy

CGRP receptor activity in mice with global expression of human receptor activity modifying protein 1

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BRITISH JOURNAL OF PHARMACOLOGY (2017)

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Meningeal blood flow is controlled by H2S-NO crosstalk activating a HNO-TRPA1-CGRP signalling pathway

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BRITISH JOURNAL OF PHARMACOLOGY (2016)

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Article Neurosciences

Localization of CGRP receptor components and receptor binding sites in rhesus monkey brainstem: A detailed study using in situ hybridization, immunofluorescence, and autoradiography

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JOURNAL OF COMPARATIVE NEUROLOGY (2016)

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Serum MicroRNA Signatures in Migraineurs During Attacks and in Pain-Free Periods

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MOLECULAR NEUROBIOLOGY (2016)

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Article Physiology

Mapping the calcitonin receptor in human brain stem

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AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2016)

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Review Pharmacology & Pharmacy

Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles

Debbie L. Hay et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 56 (2016)

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Article Clinical Neurology

Migraine photophobia originating in cone-driven retinal pathways

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BRAIN (2016)

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Article Cardiac & Cardiovascular Systems

The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis

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CARDIOVASCULAR RESEARCH (2016)

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Article Cell Biology

Parabrachial CGRP Neurons Control Meal Termination

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CELL METABOLISM (2016)

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Amylin receptor components and the leptin receptor are co-expressed in single rat area postrema neurons

Claudia G. Liberini et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2016)

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Article Pharmacology & Pharmacy

Long acting analogue of the calcitonin gene-related peptide induces positive metabolic effects and secretion of the glucagon-like peptide-1

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EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

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Article Biochemistry & Molecular Biology

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors

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JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Vasculo-Neuronal Coupling: Retrograde Vascular Communication to Brain Neurons

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JOURNAL OF NEUROSCIENCE (2016)

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Article Genetics & Heredity

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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NATURE GENETICS (2016)

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NATURE METHODS (2016)

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CONTRIBUTION OF SYNAPTIC PLASTICITY IN THE INSULAR CORTEX TO CHRONIC PAIN

Min Zhuo

NEUROSCIENCE (2016)

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Review Neurosciences

NEUROVASCULAR CONTRIBUTIONS TO MIGRAINE: MOVING BEYOND VASODILATION

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NEUROSCIENCE (2016)

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Article Neurosciences

IMMUNOHISTOCHEMICAL LOCALIZATION OF THE CALCITONIN GENE-RELATED PEPTIDE BINDING SITE IN THE PRIMATE TRIGEMINOVASCULAR SYSTEM USING FUNCTIONAL ANTAGONIST ANTIBODIES

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NEUROSCIENCE (2016)

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Article Anesthesiology

Premonitory and nonheadache symptoms induced by CGRP and PACAP38 in patients with migraine

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PAIN (2016)

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Involvement of CGRP receptors in retinal spreading depression

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PHARMACOLOGICAL REPORTS (2016)

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Review Pharmacology & Pharmacy

Wiping Out CGRP: Potential Cardiovascular Risks

Antoinette MaassenVanDenBrink et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2016)

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Article Multidisciplinary Sciences

Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour

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NATURE COMMUNICATIONS (2016)

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Genetically and functionally defined NTS to PBN brain circuits mediating anorexia

Carolyn W. Roman et al.

NATURE COMMUNICATIONS (2016)

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Pharmacologic Characterization of AMG 334, a Potent and Selective Human Monoclonal Antibody against the Calcitonin Gene-Related Peptide Receptor

Licheng Shi et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)

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Review Pharmacology & Pharmacy

Calcitonin Gene-Related Peptide (CGRP): A New Target for Migraine

Andrew F. Russo

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 (2015)

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Article Neurosciences

Localization of CGRP, CGRP receptor, PACAP and glutamate in trigeminal ganglion. Relation to the blood-brain barrier

Sajedeh Eftekhari et al.

BRAIN RESEARCH (2015)

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Article Pharmacology & Pharmacy

CGRP receptor antagonists and antibodies against CGRP and its receptor in migraine treatment

Lars Edvinsson

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2015)

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Article Cell Biology

Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake

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CELL METABOLISM (2015)

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Article Clinical Neurology

Periaqueductal gray calcitonin gene-related peptide modulates trigeminovascular neurons

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CEPHALALGIA (2015)

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Review Pharmacology & Pharmacy

Bench-to-bedside pharmacology of adrenomedullin

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EUROPEAN JOURNAL OF PHARMACOLOGY (2015)

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Article Clinical Neurology

Experimental inflammation following dural application of complete Freund's adjuvant or inflammatory soup does not alter brain and trigeminal microvascular passage

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JOURNAL OF HEADACHE AND PAIN (2015)

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Migraine: Multiple Processes, Complex Pathophysiology

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JOURNAL OF NEUROSCIENCE (2015)

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Article Neurosciences

Parabrachial Calcitonin Gene-Related Peptide Neurons Mediate Conditioned Taste Aversion

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JOURNAL OF NEUROSCIENCE (2015)

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Article Biochemistry & Molecular Biology

Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor

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MOLECULAR CELL (2015)

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Evidence for orexinergic mechanisms in migraine

Jan Hoffmann et al.

NEUROBIOLOGY OF DISEASE (2015)

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OnabotulinumtoxinA decreases interictal CGRP plasma levels in patients with chronic migraine

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PAIN (2015)

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Article Multidisciplinary Sciences

RNA-Seq Analysis of Human Trigeminal and Dorsal Root Ganglia with a Focus on Chemoreceptors

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PLOS ONE (2015)

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PROCALCITONIN LEVELS IN SURVIVORS AND NONSURVIVORS OF SEPSIS: SYSTEMATIC REVIEW AND META-ANALYSIS

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SHOCK (2015)

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Clinical, Histologic, and Molecular Analysis of Differences Between Erythematotelangiectatic Rosacea and Telangiectatic Photoaging

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JAMA DERMATOLOGY (2015)

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Article Physiology

Calcitonin gene-related peptide inhibits human immunodeficiency type 1 transmission by Langerhans cells via an autocrine/paracrine feedback mechanism

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ACTA PHYSIOLOGICA (2015)

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Article Neurosciences

Neurochemical properties of the synapses between the parabrachial nucleus-derived CGRP-positive axonal terminals and the GABAergic neurons in the lateral capsular division of central nucleus of amygdala

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MOLECULAR NEUROBIOLOGY (2015)

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Article Clinical Neurology

A second trigeminal CGRP receptor: function and expression of the AMY1 receptor

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ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2015)

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Review Pharmacology & Pharmacy

Amylin: Pharmacology, Physiology, and Clinical Potential

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PHARMACOLOGICAL REVIEWS (2015)

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Article Clinical Neurology

Inverse neurovascular coupling to cortical spreading depolarizations in severe brain trauma

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BRAIN (2014)

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Article Pharmacology & Pharmacy

Structure-activity relationships of the N-terminus of calcitonin gene-related peptide: key roles of alanine-5 and threonine-6 in receptor activation

Debbie L. Hay et al.

BRITISH JOURNAL OF PHARMACOLOGY (2014)

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Article Biochemistry & Molecular Biology

TRPV1 Pain Receptors Regulate Longevity and Metabolism by Neuropeptide Signaling

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CELL (2014)

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Glutamate Receptor Antagonists in the Management of Migraine

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DRUGS (2014)

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Article Endocrinology & Metabolism

Activity of Pramlintide, Rat and Human Amylin but not Aβ1-42 at Human Amylin Receptors

Joseph J. Gingell et al.

ENDOCRINOLOGY (2014)

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Article Clinical Neurology

Reactive Oxygen Species Induce Procalcitonin Expression in Trigeminal Ganglia Glia

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HEADACHE (2014)

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Article Peripheral Vascular Disease

An Ongoing Role of α-Calcitonin Gene-Related Peptide as Part of a Protective Network Against Hypertension, Vascular Hypertrophy, and Oxidative Stress

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HYPERTENSION (2014)

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Article Neurosciences

Antipsychotic-Like Actions of the Satiety Peptide, Amylin, in Ventral Striatal Regions Marked by Overlapping Calcitonin Receptor and RAMP-1 Gene Expression

Sarah K. Baisley et al.

JOURNAL OF NEUROSCIENCE (2014)

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Article Neurosciences

Loss of α-Calcitonin Gene-Related Peptide (αCGRP) Reduces the Efficacy of the Vestibulo-ocular Reflex (VOR)

Anne E. Luebke et al.

JOURNAL OF NEUROSCIENCE (2014)

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Article Neurosciences

Multimodal Use of Calcitonin Gene-Related Peptide and Substance P in Itch and Acute Pain Uncovered by the Elimination of Vesicular Glutamate Transporter 2 from Transient Receptor Potential Cation Channel Subfamily V Member 1 Neurons

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JOURNAL OF NEUROSCIENCE (2014)

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Article Neurosciences

GluA1 Phosphorylation Contributes to Postsynaptic Amplification of Neuropathic Pain in the Insular Cortex

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JOURNAL OF NEUROSCIENCE (2014)

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Article Clinical Neurology

Randomized controlled trial of the CGRP receptor antagonist telcagepant for migraine prevention

Tony W. Ho et al.

NEUROLOGY (2014)

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Article Neurosciences

mRNA distribution of CGRP and its receptor components in the trigeminovascular system and other pain related structures in rat brain, and effect of intracerebroventricular administration of CGRP on Fos expression in the TNC

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NEUROSCIENCE LETTERS (2014)

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Review Physiology

CALCITONIN GENE-RELATED PEPTIDE: PHYSIOLOGY AND PATHOPHYSIOLOGY

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PHYSIOLOGICAL REVIEWS (2014)

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Article Orthopedics

Development of a novel antibody to calcitonin gene-related peptide for the treatment of osteoarthritis-related pain

R. J. Benschop et al.

OSTEOARTHRITIS AND CARTILAGE (2014)

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Article Biochemistry & Molecular Biology

α-Calcitonin gene related peptide (α-CGRP) mediated lipid mobilization in 3T3-L1 adipocytes

Christopher S. Walker et al.

PEPTIDES (2014)

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Article Multidisciplinary Sciences

Heat Hyperalgesia and Mechanical Hypersensitivity Induced by Calcitonin Gene-Related Peptide in a Mouse Model of Neurofibromatosis

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PLOS ONE (2014)

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Article Multidisciplinary Sciences

Neurochemical Pathways That Converge on Thalamic Trigeminovascular Neurons: Potential Substrate for Modulation of Migraine by Sleep, Food Intake, Stress and Anxiety

Rodrigo Noseda et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway

Mirjam Eberhardt et al.

NATURE COMMUNICATIONS (2014)

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Review Neurosciences

Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis

Bakri M. Assas et al.

FRONTIERS IN NEUROSCIENCE (2014)

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Article Pharmacology & Pharmacy

Glutamate, Substance P, and Calcitonin Gene-Related Peptide Cooperate in Inflammation-Induced Heat Hyperalgesia

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MOLECULAR PHARMACOLOGY (2014)

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Article Behavioral Sciences

Anxiogenic effects of CGRP within the BNST may be mediated by CRF acting at BNST CRFR1 receptors

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BEHAVIOURAL BRAIN RESEARCH (2013)

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Article Chemistry, Medicinal

Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): A potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

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Review Medicine, General & Internal

Epigenetic mechanisms in migraine: a promising avenue?

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BMC MEDICINE (2013)

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Article Pharmacology & Pharmacy

Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Δ(1-47)hCT(a) function

T. Qi et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

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Review Pharmacology & Pharmacy

CGRP in the trigeminovascular system: a role for CGRP, adrenomedullin and amylin receptors?

C. S. Walker et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

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Review Pharmacology & Pharmacy

Structure-activity relationships for α-calcitonin gene-related peptide

Harriet A. Watkins et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

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Article Neurosciences

Localization of CGRP Receptor Components, CGRP, and Receptor Binding Sites in Human and Rhesus Cerebellar Cortex

Sajedeh Eftekhari et al.

CEREBELLUM (2013)

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Review Biochemistry & Molecular Biology

Roles of CLR/RAMP Receptor Signaling in Reproduction and Development

Chia Lin Chang et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2013)

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Article Neurosciences

Neuropeptide receptors provide a signalling pathway for trigeminal modulation of olfactory transduction

Philipp Daiber et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2013)

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Article Immunology

Calcitonin gene-related peptide inhibits Langerhans cell-mediated HIV-1 transmission

Yonatan Ganor et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

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Article Clinical Neurology

Changes in calcitonin gene-related peptide (CGRP) receptor component and nitric oxide receptor (sGC) immunoreactivity in rat trigeminal ganglion following glyceroltrinitrate pretreatment

Kristin Seiler et al.

JOURNAL OF HEADACHE AND PAIN (2013)

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Article Dermatology

Epidermal Nerve Fibers Modulate Keratinocyte Growth via Neuropeptide Signaling in an Innervated Skin Model

Dennis Roggenkamp et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)

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Article Clinical Neurology

Differentiation of Nerve Fibers Storing CGRP and CGRP Receptors in the Peripheral Trigeminovascular System

Sajedeh Eftekhari et al.

JOURNAL OF PAIN (2013)

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Article Multidisciplinary Sciences

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies

Shabana Vohra et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2013)

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Article Multidisciplinary Sciences

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach

Michael. J. Woolley et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2013)

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Article Multidisciplinary Sciences

Genetic identification of a neural circuit that suppresses appetite

Matthew E. Carter et al.

NATURE (2013)

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Review Clinical Neurology

Cortical spreading depression and migraine

Andrew C. Charles et al.

NATURE REVIEWS NEUROLOGY (2013)

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Article Clinical Neurology

Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine

Eva Cernuda-Morollon et al.

NEUROLOGY (2013)

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Article Endocrinology & Metabolism

CGRP and migraine: Could PACAP play a role too?

Eric A. Kaiser et al.

NEUROPEPTIDES (2013)

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CORTICAL SPREADING DEPRESSION INDUCES OXIDATIVE STRESS IN THE TRIGEMINAL NOCICEPTIVE SYSTEM

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EVIDENCE FOR ANTI-INFLAMMATORY AND PUTATIVE ANALGESIC EFFECTS OF A MONOCLONAL ANTIBODY TO CALCITONIN GENE-RELATED PEPTIDE

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NEUROSCIENCE (2013)

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Article Anesthesiology

The CGRP receptor antagonist BIBN4096BS peripherally alleviates inflammatory pain in rats

Silke Hirsch et al.

PAIN (2013)

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Comprehensive RNA-Seq Expression Analysis of Sensory Ganglia with a Focus on Ion Channels and GPCRs in Trigeminal Ganglia

Stavros Manteniotis et al.

PLOS ONE (2013)

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Article Biochemistry & Molecular Biology

Selective CGRP and adrenomedullin peptide binding by tethered RAMP-calcitonin receptor-like receptor extracellular domain fusion proteins

Heather E. Moad et al.

PROTEIN SCIENCE (2013)

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Article Pharmacology & Pharmacy

Endosomal proteolysis regulates calcitonin gene-related peptide responses in mesenteric arteries

A. J. McNeish et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

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Review Pharmacology & Pharmacy

Consequences of splice variation on Secretin family G protein-coupled receptor function

Sebastian G. B. Furness et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

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Article Pharmacology & Pharmacy

Pharmacological characterization of rat amylin receptors: implications for the identification of amylin receptor subtypes

R. J. Bailey et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

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Review Pharmacology & Pharmacy

Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraine

Eric L. Moore et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

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Article Clinical Neurology

Migraine is not primarily a vascular disorder

Andrew Charles

CEPHALALGIA (2012)

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Vascular changes have a primary role in migraine

Messoud Ashina

CEPHALALGIA (2012)

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Article Clinical Neurology

Primary trigeminal afferents are the main source for stimulus-induced CGRP release into jugular vein blood and CSF

Jan Hoffmann et al.

CEPHALALGIA (2012)

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Review Biochemistry & Molecular Biology

Brainstem Neuropeptides and Vagal Protection of the Gastric Mucosal Against Injury: Role of Prostaglandins, Nitric Oxide and Calcitonin-Gene Related Peptide in Capsaicin Afferents

Y. Tache

CURRENT MEDICINAL CHEMISTRY (2012)

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Article Gastroenterology & Hepatology

Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis

Matthias A. Engel et al.

DIGESTIVE AND LIVER DISEASE (2012)

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Article Biochemistry & Molecular Biology

Amylin is a novel neuropeptide with potential maternal functions in the rat

Eva Rebeka Szabo et al.

FASEB JOURNAL (2012)

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Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: Implications for photophobia

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HUMAN BRAIN MAPPING (2012)

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Calcitonin gene-related peptide enhances experimental autoimmune encephalomyelitis by promoting Th17-cell functions

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INTERNATIONAL IMMUNOLOGY (2012)

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Sensitization of the Trigeminovascular Pathway: Perspective and Implications to Migraine Pathophysiology

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JOURNAL OF CLINICAL NEUROLOGY (2012)

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The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons

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Brain-derived neurotrophic factor in primary headaches

Marlene Fischer et al.

JOURNAL OF HEADACHE AND PAIN (2012)

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Modulation of CGRP-Induced Light Aversion in Wild-Type Mice by a 5-HT1B/D Agonist

Eric A. Kaiser et al.

JOURNAL OF NEUROSCIENCE (2012)

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Review Neurosciences

Neuropeptide Transmission in Brain Circuits

Anthony N. van den Pol

NEURON (2012)

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The role of glutamic acid 73 in adrenomedullin interactions with rodent AM2 receptors

Angela Halim et al.

PEPTIDES (2012)

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Critical role of calcitonin gene-related peptide receptors in cortical spreading depression

Alessandro Tozzi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Endocrinology & Metabolism

Brain-derived neurotrophic factor enhances the contraction of intestinal muscle strips induced by SP and CGRP in mice

Fei-xue Chen et al.

REGULATORY PEPTIDES (2012)

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Review Endocrinology & Metabolism

Adrenomedullin and pregnancy: perspectives from animal models to humans

Patricia M. Lenhart et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2012)

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Effects of estrogen on the serotonergic system and calcitonin generelated peptide in trigeminal ganglia of rats

Milan Aggarwal et al.

ANNALS OF NEUROSCIENCES (2012)

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Editorial Material Clinical Neurology

The Vascular Theory of Migraine: Leave It Or Love It?

Dan Levy et al.

ANNALS OF NEUROLOGY (2011)

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Article Clinical Neurology

Evidence for a Vascular Factor in Migraine

Mohammad S. Asghar et al.

ANNALS OF NEUROLOGY (2011)

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Activation of Central Trigeminovascular Neurons by Cortical Spreading Depression

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ANNALS OF NEUROLOGY (2011)

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Article Oncology

Dual-Specificity MAP Kinase Phosphatases as Targets of Cancer Treatment

Caroline Nunes-Xavier et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2011)

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Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level

Sajedeh Eftekhari et al.

BMC NEUROSCIENCE (2011)

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Cortical spreading depression affects reactive oxygen species production

Alessandro Viggiano et al.

BRAIN RESEARCH (2011)

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Role of different brain areas in peripheral nerve injury-induced neuropathic pain

Amteshwar Singh Jaggi et al.

BRAIN RESEARCH (2011)

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Article Clinical Neurology

Organ culture of the trigeminal ganglion induces enhanced expression of calcitonin gene-related peptide via activation of extracellular signal-regulated protein kinase 1/2

Janos Tajti et al.

CEPHALALGIA (2011)

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Article Clinical Neurology

Increase in CGRP- and nNOS-immunoreactive neurons in the rat trigeminal ganglion after infusion of an NO donor

Anne Dieterle et al.

CEPHALALGIA (2011)

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Article Clinical Neurology

Epigenetic regulation of the calcitonin gene-related peptide gene in trigeminal glia

Ki-Youb Park et al.

CEPHALALGIA (2011)

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Review Clinical Neurology

Possible site of action of CGRP antagonists in migraine

Peer Tfelt-Hansen et al.

CEPHALALGIA (2011)

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Review Pharmacology & Pharmacy

Pramlintide and the treatment of diabetes: a review of the data since its introduction

Lisa M. Younk et al.

EXPERT OPINION ON PHARMACOTHERAPY (2011)

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Review Biochemistry & Molecular Biology

Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation

Ann C. Raddant et al.

EXPERT REVIEWS IN MOLECULAR MEDICINE (2011)

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Article Clinical Neurology

Sex Differences in Behavior and Expression of CGRP-Related Genes in a Rodent Model of Chronic Migraine

Nicholas L. Stucky et al.

HEADACHE (2011)

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Article Clinical Neurology

Calcitonin Gene-Related Peptide Does Not Cause Migraine Attacks in Patients With Familial Hemiplegic Migraine

Jakob M. Hansen et al.

HEADACHE (2011)

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Review Gastroenterology & Hepatology

Role of Sensory Neurons in Colitis: Increasing Evidence for a Neuroimmune Link in the Gut

Matthias A. Engel et al.

INFLAMMATORY BOWEL DISEASES (2011)

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Article Endocrinology & Metabolism

Glucose-Dependent Insulinotropic Polypeptide (GIP) Induces Calcitonin Gene-Related Peptide (CGRP)-I and Procalcitonin (Pro-CT) Production in Human Adipocytes

Katharina Timper et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

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Article Medicine, Research & Experimental

CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice

Weiliang Xie et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

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Review Dermatology

Neurovascular Aspects of Skin Neurogenic Inflammation

Aisah A. Aubdool et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS (2011)

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Calcitonin Gene-Related Peptide in the Bed Nucleus of the Stria Terminalis Produces an Anxiety-Like Pattern of Behavior and Increases Neural Activation in Anxiety-Related Structures

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JOURNAL OF NEUROSCIENCE (2011)

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Article Neurosciences

Calcitonin Gene-Related Peptide-Mediated Enhancement of Purinergic Neuron/Glia Communication by the Algogenic Factor Bradykinin in Mouse Trigeminal Ganglia from Wild-Type and R192Q Cav2.1 Knock-In Mice: Implications for Basic Mechanisms of Migraine Pain

Stefania Ceruti et al.

JOURNAL OF NEUROSCIENCE (2011)

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Article Neurosciences

Cerebellar distribution of calcitonin gene-related peptide (CGRP) and its receptor components calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1) in rat

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MOLECULAR AND CELLULAR NEUROSCIENCE (2011)

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Article Neurosciences

Calcitonin Gene-Related Peptide Promotes Cellular Changes in Trigeminal Neurons and Glia Implicated in Peripheral and Central Sensitization

Ryan J. Cady et al.

MOLECULAR PAIN (2011)

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Editorial Material Clinical Neurology

CGRP Sensory neuropeptide with multiple neurologic implications

Eduardo E. Benarroch

NEUROLOGY (2011)

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Review Endocrinology & Metabolism

Calcitonin gene-related peptide (CGRP) and its role in hypertension

Sarah-Jane Smillie et al.

NEUROPEPTIDES (2011)

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Article Anesthesiology

Keratinocyte expression of calcitonin gene-related peptide β: Implications for neuropathic and inflammatory pain mechanisms

Quanzhi Hou et al.

PAIN (2011)

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Article Clinical Neurology

Thalamic Sensitization Transforms Localized Pain into Widespread Allodynia

Rami Burstein et al.

ANNALS OF NEUROLOGY (2010)

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Article Cardiac & Cardiovascular Systems

Calcitonin gene-related peptide inhibits angiotensin II-induced endothelial progenitor cells senescence through up-regulation of klotho expression

Zhi Zhou et al.

ATHEROSCLEROSIS (2010)

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Article Biochemistry & Molecular Biology

Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

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Article Clinical Neurology

Modulation of nocioceptive transmission with calcitonin gene-related peptide receptor antagonists in the thalamus

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BRAIN (2010)

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Article Clinical Neurology

Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura

Jakob Moller Hansen et al.

CEPHALALGIA (2010)

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Editorial Material Clinical Neurology

Dopamine: what's new in migraine?

Annabelle R. Charbit et al.

CURRENT OPINION IN NEUROLOGY (2010)

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An update on the blood vessel in migraine

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CURRENT OPINION IN NEUROLOGY (2010)

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What have we learnt from triggering migraine?

Henrik W. Schytz et al.

CURRENT OPINION IN NEUROLOGY (2010)

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Article Endocrinology & Metabolism

Mice Lacking the Neuropeptide α-Calcitonin Gene-Related Peptide Are Protected Against Diet-Induced Obesity

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ENDOCRINOLOGY (2010)

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Review Pharmacology & Pharmacy

Mitogen-activated protein kinase phosphatase-1-a potential therapeutic target in metabolic disease

Rachel J. Roth Flach et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2010)

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Review Clinical Neurology

Migraine Pain and Nociceptor Activation-Where Do We Stand?

Dan Levy

HEADACHE (2010)

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Review Clinical Neurology

Verisimilitude (or truthlikeness) as an alternative to pro and cons: migraine and cluster headache mechanisms

Peer Carsten Tfelt-Hansen

JOURNAL OF HEADACHE AND PAIN (2010)

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Article Neurosciences

Activation of Meningeal Nociceptors by Cortical Spreading Depression: Implications for Migraine with Aura

XiChun Zhang et al.

JOURNAL OF NEUROSCIENCE (2010)

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Article Pharmacology & Pharmacy

Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist

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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)

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Article Neurosciences

Facilitation of synaptic transmission and pain responses by CGRP in the amygdala of normal rats

Jeong S. Han et al.

MOLECULAR PAIN (2010)

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A neural mechanism for exacerbation of headache by light

Rodrigo Noseda et al.

NATURE NEUROSCIENCE (2010)

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Review Clinical Neurology

CGRP and its receptors provide new insights into migraine pathophysiology

Tony W. Ho et al.

NATURE REVIEWS NEUROLOGY (2010)

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Induction of multiple photophobic behaviors in a transgenic mouse sensitized to CGRP

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NEUROPHARMACOLOGY (2010)

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Article Neurosciences

AMYLIN SUPPRESSES ACETIC ACID-INDUCED VISCERAL PAIN AND SPINAL C-FOS EXPRESSION IN THE MOUSE

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NEUROSCIENCE (2010)

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Article Neurosciences

DIFFERENTIAL DISTRIBUTION OF CALCITONIN GENE-RELATED PEPTIDE AND ITS RECEPTOR COMPONENTS IN THE HUMAN TRIGEMINAL GANGLION

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NEUROSCIENCE (2010)

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Article Neurosciences

Calcitonin gene-related peptide differentially regulates gene and protein expression in trigeminal glia cells: Findings from array analysis

Carrie V. Vause et al.

NEUROSCIENCE LETTERS (2010)

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Article Medicine, General & Internal

Triptan Therapy in Migraine

Elizabeth Loder

NEW ENGLAND JOURNAL OF MEDICINE (2010)

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Calcitonin gene-related peptide regulates the growth of epidermal stem cells in vitro

Jie Dong et al.

PEPTIDES (2010)

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Article Biochemistry & Molecular Biology

Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism

Ernst ter Haar et al.

STRUCTURE (2010)

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Review Pharmacology & Pharmacy

Regulation of signal transduction by calcitonin gene-related peptide receptors

Christopher S. Walker et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2010)

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Neuropeptides in the rat corpus cavernosum and seminal vesicle: Effects of age and two types of diabetes

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AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2009)

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Article Clinical Neurology

PACAP38 induces migraine-like attacks in patients with migraine without aura

Henrik Winther Schytz et al.

BRAIN (2009)

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Editorial Material Clinical Neurology

The vascular theory of migrainea great story wrecked by the facts

Peter J. Goadsby

BRAIN (2009)

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Article Clinical Neurology

Brainstem and thalamic projections from a craniovascular sensory nervous centre in the rostral cervical spinal dorsal horn of rats

Y. Liu et al.

CEPHALALGIA (2009)

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Review Pharmacology & Pharmacy

Role of Calcitonin Gene-Related Peptide in Gastric Mucosal Defence and Healing

S. Evangelista

CURRENT PHARMACEUTICAL DESIGN (2009)

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Article Pharmacology & Pharmacy

Examining the binding properties of MK-0974: A CGRP receptor antagonist for the acute treatment of migraine

Eric L. Moore et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2009)

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Article Pharmacology & Pharmacy

Involvement of afferent neurons in the pathogenesis of endotoxin-induced ileus in mice: Role of CGRP and TRPV1 receptors

Benedicte Y. De Winter et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2009)

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Article Clinical Neurology

Elevated Saliva Calcitonin Gene-Related Peptide Levels During Acute Migraine Predict Therapeutic Response to Rizatriptan

Roger K. Cady et al.

HEADACHE (2009)

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Article Physiology

Role of calcitonin gene-related peptide (CGRP) in ovine burn and smoke inhalation injury

Matthias Lange et al.

JOURNAL OF APPLIED PHYSIOLOGY (2009)

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Article Neurosciences

Sensory Innervation of the Calvarial Bones of the Mouse

Bela Kosaras et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2009)

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Article Clinical Neurology

Plasma calcitonin gene-related peptide concentration is comparable to control group among migraineurs and tension type headache subjects during inter-ictal period

Ravi Gupta et al.

JOURNAL OF HEADACHE AND PAIN (2009)

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Review Clinical Neurology

Calcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? A review

Peer Tfelt-Hansen et al.

JOURNAL OF HEADACHE AND PAIN (2009)

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Article Biochemistry & Molecular Biology

Central amylin expression and its induction in rat dams

Arpad Dobolyi

JOURNAL OF NEUROCHEMISTRY (2009)

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Article Neurosciences

Neurons of the Dopaminergic/Calcitonin Gene-Related Peptide A11 Cell Group Modulate Neuronal Firing in the Trigeminocervical Complex: An Electrophysiological and Immunohistochemical Study

Annabelle R. Charbit et al.

JOURNAL OF NEUROSCIENCE (2009)

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Article Clinical Neurology

Genetic Enhancement of Calcitonin Gene-Related Peptide-Induced Central Sensitization to Mechanical Stimuli in Mice

Blanca Marquez de Prado et al.

JOURNAL OF PAIN (2009)

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Article Clinical Neurology

Origin of pain in migraine: evidence for peripheral sensitisation

Jes Olesen et al.

LANCET NEUROLOGY (2009)

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Article Neurosciences

Proinflammatory-activated trigeminal satellite cells promote neuronal sensitization: relevance for migraine pathology

Alessandro Capuano et al.

MOLECULAR PAIN (2009)

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Review Geriatrics & Gerontology

Calcitonin gene-related peptide, adrenomedullin and flushing

Debbie L. Hay et al.

MATURITAS (2009)

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Article Clinical Neurology

Neural substrate of depression during migraine

Rami Burstein et al.

NEUROLOGICAL SCIENCES (2009)

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Review Pharmacology & Pharmacy

The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs

Carlos M. Villalon et al.

PHARMACOLOGY & THERAPEUTICS (2009)

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Article Behavioral Sciences

A role for the medial preoptic area in CGRP-induced suppression of pulsatile LH secretion in the female rat

X. F. Li et al.

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS (2009)

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Review Neurosciences

Migraine: where and how does the pain originate?

Karl Messlinger

EXPERIMENTAL BRAIN RESEARCH (2009)

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Review Pharmacology & Pharmacy

Proteases for processing proneuropeptides into peptide neurotransmitters and hormones

Vivian Hook et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2008)

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Article Neurosciences

Central projections of the sensory innervation of the rat middle meningeal artery

Yi Liu et al.

BRAIN RESEARCH (2008)

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Article Pharmacology & Pharmacy

CGRP blockers in migraine therapy: where do they act?

L. Edvinsson

BRITISH JOURNAL OF PHARMACOLOGY (2008)

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Review Clinical Neurology

The blood-brain barrier in migraine treatment

L. Edvinsson et al.

CEPHALALGIA (2008)

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Article Clinical Neurology

Comparison of CGRP and NO responses in the human peripheral microcirculation of migraine and control subjects

M-L Edvinsson et al.

CEPHALALGIA (2008)

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Article Critical Care Medicine

Procalcitonin has bioactivity at calcitonin receptor family complexes: Potential mediator implications in sepsis

Patrick M. Sexton et al.

CRITICAL CARE MEDICINE (2008)

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Article Endocrinology & Metabolism

Receptor Activity-Modifying Proteins Differentially Modulate the G Protein-Coupling Efficiency of Amylin Receptors

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ENDOCRINOLOGY (2008)

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Article Endocrinology & Metabolism

Evidence that alpha-calcitonin gene-related peptide is a neurohormone that controls systemic lipid availability and utilization

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ENDOCRINOLOGY (2008)

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Article Gastroenterology & Hepatology

Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis

Takashi Ohno et al.

GASTROENTEROLOGY (2008)

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Article Biochemistry & Molecular Biology

Mechanisms mediating the enhanced gene transcription of P2X3 receptor by calcitonin gene-related peptide in trigeminal sensory neurons

Manuela Simonetti et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Review Neurosciences

Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactlivity in the rat trigeminovascular system:: Differences between peripheral and central CGRP receptor distribution

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JOURNAL OF COMPARATIVE NEUROLOGY (2008)

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Review Neurosciences

The hemo-neural hypothesis: On the role of blood flow in information processing

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JOURNAL OF NEUROPHYSIOLOGY (2008)

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Repression of prespliceosome complex formation at two distinct steps by Fox-1/Fox-2 proteins

Hua-Lin Zhou et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

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Molecular mechanisms of sensitization of pain-transducing P2X3 receptors by the migraine mediators CGRP and NGF

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MOLECULAR NEUROBIOLOGY (2008)

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Calcitonin gene-related peptide does not cause the familial hemiplegic migraine phenotype

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NEUROLOGY (2008)

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Review Pharmacology & Pharmacy

International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor

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PHARMACOLOGICAL REVIEWS (2008)

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The effects of C-terminal truncation of receptor activity modifying proteins on the induction of amylin receptor phenotype from human CTb receptors

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REGULATORY PEPTIDES (2008)

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Control of the calcitonin gene-related peptide enhancer by upstream stimulatory factor in trigeminal ganglion neurons

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Pharmacological characterization of MK-0974 [N-[(3R, 6S)-6(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-1-yl)piperidine-1-carboxamide], a potent and orally Active calcitonin gene-related peptide receptor antagonist for the treatment of migraine

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Protective roles of alpha-calcitonin and beta-calcitonin gene-related peptide in spontaneous and experimentally induced colitis

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Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and β-arrestins

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Role of visceral afferent neurons in mucosal inflammation and defense

Peter Holzer

CURRENT OPINION IN PHARMACOLOGY (2007)

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Calcitonin gene-related peptide mediates acid-induced lung injury in mice

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RESPIROLOGY (2007)

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What makes a CGRP2 receptor?

D. L. Hay

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2007)

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Calcitonin receptor-like and receptor activity modifying protein 1 in the rat dorsal horn localization in glutamatergic presynaptic terminal containing opioids and adrenergic α2c receptor

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Calcitonin gene-related peptide induces the expression of acetylcholinesterase-associated collagen ColQ in muscle: a distinction in driving two different promoters between fast- and slow-twitch muscle fibers

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Neuron-glia signaling in trigeminal ganglion: Implications for migraine pathology

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HEADACHE (2007)

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Role of calcitonin receptor-like receptor in colonic motility and inflammation

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Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age

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Modification of classical neurochemical markers in identified primary afferent neurons with Aβ-, Aδ-, and C-fibers after chronic constriction injury in mice

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Pharmacological approaches to managing migraine and associated comorbidities - Clinical considerations for monotherapy versus polytherapy

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HEADACHE (2007)

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Involvement of endothelial cell-derived CGRP in heat stress-induced protection of endothelial function

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VASCULAR PHARMACOLOGY (2007)

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The colocalization of CGRP receptor and AMPA receptor in the spinal dorsal horn neuron of rat: A morphological and electrophysiological study

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NEUROSCIENCE LETTERS (2007)

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Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion

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Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing

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MOLECULAR AND CELLULAR BIOLOGY (2007)

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A nuclear function of Hu proteins as neuron-specific alternative RNA processing regulators

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MOLECULAR BIOLOGY OF THE CELL (2006)

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Determinants of 1-piperidinecarboxamide, N-[2-[[5-amino-l-[[4(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) affinity for calcitonin gene-related peptide and amylin receptors -: The role of receptor activity modifying protein 1

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Article Pharmacology & Pharmacy

A critical role for the short intracellular C terminus in receptor activity-modifying protein function

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MOLECULAR PHARMACOLOGY (2006)

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Pharmacological characterization of novel α-calcitonin gene-related peptide (CGRP) receptor peptide antagonists that are selective for human CGRP receptors

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Delayed upregulation of ATP P2X3 receptors of trigeminal sensory neurons by calcitonin gene-related peptide

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Pharmacology of the human CGRP1 receptor in Cos 7 cells

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Calcitonin gene-related peptide receptor activation by receptor activity-modifying protein-1 gene transfer to vascular smooth muscle cells

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ENDOCRINOLOGY (2006)

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Nitric oxide regulation of calcitonin gene-related peptide gene expression in rat trigeminal ganglia neurons

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EUROPEAN JOURNAL OF NEUROSCIENCE (2006)

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Dendritic peptide release and peptide-dependent behaviours

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Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney

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Tumor necrosis factor-alpha stimulation of calcitonin gene-related peptide expression and secretion from rat trigeminal ganglion neurons

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GPCR modulation by RAMPS

DL Hay et al.

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Salivary levels of CGRP and VIP in rhinosinusitis and migraine patients

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Endogenous NGF regulates CGRP expression in human monocytes, and affects HLA-DR and CD86 expression and IL-10 production

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No increase of calcitonin gene-related peptide in jugular blood during migraine

JF Tvedskov et al.

ANNALS OF NEUROLOGY (2005)

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Without nerves, immunology remains incomplete -: in vivo veritas

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Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat

GS Cottrell et al.

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The nonpeptide calcitonin gene-related peptide receptor antagonist BIBN4096BS lowers the activity of neurons with meningeal input in the rat spinal trigeminal nucleus

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Article Endocrinology & Metabolism

Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue

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ENDOCRINOLOGY (2005)

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Endogenous calcitonin gene-related peptide protects human alveolar epithelial cells through protein kinase Cε and heat shock protein

W Wang et al.

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Impaired capsaicin and neurokinin-evoked colonic motility in inflammatory bowel disease

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Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes

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MOLECULAR PHARMACOLOGY (2005)

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Evidence for decreased calcitonin gene-related peptide (CGRP) receptors and compromised responsiveness to CGRP of fetoplacental vessels in preeclamptic pregnancies

YL Dong et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)

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BIBN4096BS antagonizes human α-calcitonin gene related peptide-induced headache and extracerebral artery dilatation

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CLINICAL PHARMACOLOGY & THERAPEUTICS (2005)

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Sumatriptan causes parallel decrease in plasma calcitonin gene-related peptide (CGRP) concentration and migraine headache during nitroglycerin induced migraine attack

G Juhasz et al.

CEPHALALGIA (2005)

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Review Biotechnology & Applied Microbiology

Can we develop neurally acting drugs for the treatment of migraine?

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Ca2+ and frequency dependence of exocytosis in isolated somata of magnocellular supraoptic neurones of the rat hypothalamus

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Calcitonin gene-related peptide receptor antagonist BIBN4096BS for the acute treatment of migraine

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NEW ENGLAND JOURNAL OF MEDICINE (2004)

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Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes

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Peripheral amylin activates circumventricular organs expressing calcitonin receptor a/b subtypes and receptor-activity modifying proteins in the rat

SW Barth et al.

BRAIN RESEARCH (2004)

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Neuronal expression and regulation of CGRP promoter activity following viral gene transfer into cultured trigeminal ganglia neurons

PL Durham et al.

BRAIN RESEARCH (2004)

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Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator

Y Takei et al.

FEBS LETTERS (2004)

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Effect of pramlintide on symptom, catecholamine, and glucagon responses to hypoglycemia in healthy subjects

T Heise et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2004)

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Analysis of the cellular expression pattern of β-CGRP in α-CGRP-deficient mice

B Schütz et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2004)

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Calcitonin gene-related peptide (CGRP) modulates nociceptive trigeminovascular transmission in the cat

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Article Biochemistry & Molecular Biology

Both U2 snRNA and U12 snRNA are required for accurate splicing of exon 5 of the rat calcitonin/CGRP gene

JR Roesser

RNA (2004)

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Immunohistochemical mapping of calcitonin receptors in the adult rat brain

C Becskei et al.

BRAIN RESEARCH (2004)

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Vascular actions of calcitonin gene-related peptide and adrenomedullin

SD Brain et al.

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Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues

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GENE EXPRESSION PATTERNS (2004)

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Calcitonin gene-related peptide regulates gene transcription in primary afferent neurons

LE Anderson et al.

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Long-term induction of β-CGRP mRNA in rat lungs by allergic inflammation

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LIFE SCIENCES (2004)

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Regulation of the cell-specific calcitonin/calcitonin gene-related peptide enhancer by USF and the Foxa2 forkhead protein

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Central projections of sensory innervation of the rat superior sagittal sinus

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Calcitonin gene-related peptide receptor activation produces PKA- and PKC-dependent mechanical hyperalgesia and central sensitization

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The amygdala and persistent pain

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Expression of calcitonin gene-related peptide type 1 receptor mRNA and their activity-modifying proteins in the rat nucleus accumbens

N Li et al.

NEUROSCIENCE LETTERS (2004)

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Effects of alpha calcitonin gene-related peptide in human bronchial smooth muscle and pulmonary artery

J Springer et al.

REGULATORY PEPTIDES (2004)

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Three receptor-activity-modifying proteins define calcitonin gene-related peptide or adrenomedullin selectivity of the mouse calcitonin-like receptor in COS-7 cells

K Husmann et al.

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Article Pharmacology & Pharmacy

CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors:: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS

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Mechanism of interleukin-1β-induced calcitonin gene-related peptide production from dorsal root ganglion neurons of neonatal rats

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Glutamate and nitric oxide pathway in chronic daily headache: evidence from cerebrospinal fluid

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CEPHALALGIA (2003)

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Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis

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ENDOCRINOLOGY (2003)

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SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing

Q Tran et al.

BIOCHEMISTRY (2003)

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Ontogeny of calcitonin receptor mRNA and protein in the developing central nervous system of the rat

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Loss of alpha CGRP reduces sound-evoked activity in the cochlear nerve

SF Maison et al.

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Mechanisms involved in calcitonin gene-related peptide-induced relaxation in pregnant rat uterine artery

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BIOLOGY OF REPRODUCTION (2003)

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Calcitonin gene-related peptide as inflammatory mediator

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PULMONARY PHARMACOLOGY & THERAPEUTICS (2003)

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Expression and regulation of calcitonin gene-related peptide receptor in rat placentas

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BIOLOGY OF REPRODUCTION (2002)

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A comparison of the actions of BIBN4096BS and CGRP8-37 on CGRP and adrenomedullin receptors expressed on SK-N-MC, L6, Col 29 and Rat 2 cells

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Article Reproductive Biology

Infusion of pregnant rats with calcitonin gene-related peptide (CGRP)8-37, a CGRP receptor antagonist, increases blood pressure and fetal mortality and decreases fetal growth

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BIOLOGY OF REPRODUCTION (2002)

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Article Clinical Neurology

An immunocytochemical investigation of human trigeminal nucleus caudalis:: CGRP, substance P and 5-HT1D-receptor immunoreactivities are expressed by trigeminal sensory fibres

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CEPHALALGIA (2002)

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Article Pharmacology & Pharmacy

Comparison of the expression of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines

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International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors

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Adenosine A1 receptor agonists inhibit trigeminovascular nociceptive transmission

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Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists

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New insights into the molecular actions of serotonergic antimigraine drugs

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Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model

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CGRP may play a causative role in migraine

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CEPHALALGIA (2002)

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Drug therapy: Migraine - Current understanding and treatment.

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Neuropeptide expression in the human trigeminal nucleus caudalis and in the cervical spinal cord C1 and C2

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CEPHALALGIA (2002)

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Expression of receptor-activity modifying protein (RAMP) mRNAs in the mouse brain

T Ueda et al.

MOLECULAR BRAIN RESEARCH (2001)

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The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression

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Cloning, characterization and distribution of receptor activity central nervous system modifying proteins in the rat

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Levels of nerve growth factor in cerebrospinal fluid of chronic daily headache patients

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Prevalence and burden of migraine in the United States: Data from the American Migraine Study II

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HEADACHE (2001)

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Adjuvant-induced joint inflammation causes very rapid transcription of β-preprotachykinin and α-CGRP genes in innervating sensory ganglia

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The expression of calcitonin gene-related peptide in dorsal horn neurons of the mouse lumbar spinal cord

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NEUROREPORT (2001)

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Pharmacological evidence for CGRP uptake into perivascular capsaicin sensitive nerve terminals

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Capsaicin-sensitive afferents and their role in gastroprotection: an update

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Nitric oxide metabolites, prostaglandins and trigeminal vasoactive peptides in internal jugular vein blood during spontaneous migraine attacks

P Sarchielli et al.

CEPHALALGIA (2000)

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Release of calcitonin gene-related peptide (CGRP) from guinea pig dura mater in vitro is inhibited by sumatriptan but unaffected by nitric oxide

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CEPHALALGIA (2000)

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Immunohistochemical localization of amylin in rat brainstem

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Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors

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Induction and expression of β-calcitonin gene-related peptide in rat T lymphocytes and its significance

LY Xing et al.

JOURNAL OF IMMUNOLOGY (2000)

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Article Cardiac & Cardiovascular Systems

Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction

C Fernandez-Patron et al.

CIRCULATION RESEARCH (2000)

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Article Biochemistry & Molecular Biology

CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors

BN Evans et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Article Neurosciences

Anti-nociceptive effects of calcitonin gene-related peptide in nucleus raphe magnus of rats: an effect attenuated by naloxone

YH Huang et al.

BRAIN RESEARCH (2000)

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Article Endocrinology & Metabolism

Cellular localization of neprilysin in mouse bone tissue and putative role in hydrolysis of osteogenic peptides

AF Ruchon et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2000)

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Article Pharmacology & Pharmacy

CGRP2 receptor in the internal anal sphincter of the rat:: implications for CGRP receptor classification

FM Wisskirchen et al.

BRITISH JOURNAL OF PHARMACOLOGY (2000)

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Article Neurosciences

Localization of calcitonin receptor mRNA in the mouse brain: coexistence with serotonin transporter mRNA

H Nakamoto et al.

MOLECULAR BRAIN RESEARCH (2000)

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Article Cardiac & Cardiovascular Systems

In vivo gene transfer of prepro-calcitonin gene-related peptide to the lung attenuates chronic hypoxia-induced pulmonary hypertension in the mouse

HC Champion et al.

CIRCULATION (2000)

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Article Pharmacology & Pharmacy

CGRP and adrenomedullin binding correlates with transcript levels for Calcitonin Receptor-Like Receptor (CRLR) and Receptor Activity Modifying Proteins (RAMPs) in rat tissues

P Chakravarty et al.

BRITISH JOURNAL OF PHARMACOLOGY (2000)

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Article Pharmacology & Pharmacy

Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist

H Doods et al.

BRITISH JOURNAL OF PHARMACOLOGY (2000)

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Article Neurosciences

Calcitonin gene-related peptide-like immunoreactivity marks putative visceral sensory pathways in human brain

S De Lacalle et al.

NEUROSCIENCE (2000)

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Article Biochemistry & Molecular Biology

Digestive motor effects and vascular actions of CGRP in dog are expressed by different receptor subtypes

MC L'Heureux et al.

PEPTIDES (2000)

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