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DETERMINANTS, MAINTENANCE, AND FUNCTION OF ORGANELLAR pH

PHYSIOLOGICAL REVIEWS (2023)

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Article Biochemistry & Molecular Biology

Fluorescence Lifetime Imaging of pH along the Secretory Pathway

Peter T. A. Linders et al.

Summary: This study developed a method for measuring intracellular pH using fluorescence lifetime imaging microscopy (FLIM) with a single excitation wavelength. The methodology was validated and used to analyze dynamic pH changes within cells. The presented toolbox allows for high spatial and temporal resolution measurements of intracellular pH and is important for assessing organellar pH in disease models.

ACS CHEMICAL BIOLOGY (2022)

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Article Cell Biology

Detection and quantification of the vacuolar H+ATPase using the Legionella effector protein SidK

Michelle E. Maxson et al.

Summary: This study shows that proton-pumping vacuolar H+ ATPases (V-ATPases) are responsible for the acidic environment in secretory and endocytic organelles. The researchers developed a new probe derived from SidK protein to visualize and quantify V-ATPases with high specificity. They found that the density of V-ATPases increases during phagosome maturation and their distribution varies in lysosomes depending on their subcellular localization.

JOURNAL OF CELL BIOLOGY (2022)

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Review Cell Biology

Golgi Metal Ion Homeostasis in Human Health and Diseases

Jie Li et al.

Summary: The Golgi apparatus is a vital organelle involved in protein processing and trafficking, and its functions rely on a stable microenvironment and metal ion homeostasis. Transporters play a crucial role in maintaining the metal ion balance, and mutations in these transporters can lead to human diseases.

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Article Cell Biology

TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?

Einar Krogsaeter et al.

Summary: Neurodegenerative diseases (ND) pose a serious health burden and are characterized by the accumulation of damaged proteins. Lysosomes, responsible for protein clearance, play a crucial role in neurodegeneration. Lysosomal storage disorders (LSDs) are severe neurodegenerative diseases caused by mutations in lysosomal enzymes or membrane proteins. Defects in intracellular transport pathways involving endosomes and lysosomes contribute to the pathology of ND.

CELL CALCIUM (2022)

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Article Multidisciplinary Sciences

Defining mitochondrial protein functions through deep multiomic profiling

Jarred W. Rensvold et al.

Summary: Mitochondria, as the epicentres of eukaryotic metabolism and bioenergetics, are linked to numerous diseases. However, the functions of many mitochondrial proteins are still unclear, and the genetic basis of many mitochondrial disorders remains unresolved. Through mass spectrometry-based multiomics analyses, we have established a comprehensive functional compendium of human mitochondrial proteins, providing a foundation for mechanistic investigations and genetic diagnosis of mitochondrial diseases. Our findings have identified specific proteins associated with mitochondrial function and disorders, and defined a rich cell signature of mitochondrial dysfunction.

NATURE (2022)

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Article Cell Biology

Proton-gated anion transport governs macropinosome shrinkage

Mariia Zeziulia et al.

Summary: Zeziulia et al. identified the proton-activated Cl- channel ASOR/TMEM206 as necessary for the shrinkage of macrophage macropinosomes, which plays a crucial role in sorting and trafficking of cellular organelles. The activation of ASOR requires depolarization mediated by Na+ and acidification by transporters such as H+-ATPases.

NATURE CELL BIOLOGY (2022)

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Review Physiology

MITOCHONDRIAL CALCIUM EXCHANGE IN PHYSIOLOGY AND DISEASE

Joanne F. Garbincius et al.

Summary: The uptake and extrusion of calcium into and from the mitochondrial matrix have significant effects on cellular metabolism, signaling, and survival. Disruption of mitochondrial calcium cycling is associated with various diseases and inherited neuromuscular disorders. This review provides an overview of the molecular machinery involved in calcium flux across the inner mitochondrial membrane and discusses the physiological implications and potential therapeutic interventions for diseases characterized by aberrant calcium handling. Critical unanswered questions regarding the biology of calcium flux are also highlighted.

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Lysosomal dysfunction in neurodegeneration: emerging concepts and methods

Vinod Udayar et al.

Summary: The understanding of lysosomes has advanced significantly, and their importance in cell signaling, transcription, and metabolism is now recognized. Genes regulating lysosomal function are implicated in neurodegenerative diseases. Technological advances have deepened our understanding of lysosomes in neurodegeneration and led to the development of disease-specific models.

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pH regulates potassium conductance and drives a constitutive proton current in human TMEM175

Wang Zheng et al.

Summary: Human TMEM175 plays a crucial role in endolysosomes and may be involved in the pathogenesis of Parkinson's disease. It exhibits different K+ and proton permeability under varying pH conditions, sharing the same permeation pathway. Mutations associated with Parkinson's disease show reduced function in TMEM175.

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Parkinson's disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes

Meiqin Hu et al.

Summary: A genetic risk factor for Parkinson's disease, TMEM175, acts as a proton-activated, proton-selective channel on the lysosomal membrane to regulate lysosomal H+ leak. Activation of TMEM175 stops further acidification of lysosomes beyond the normal range. Deficiency of TMEM175 causes lysosomal over-acidification, impaired proteolytic activity, and facilitates alpha-synuclein aggregation.

CELL (2022)

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Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance

Xavier Leray et al.

Summary: The acidic pH of lysosomes is essential for their proper degrative function, and ClC-7 plays a role in this acidification process. PI(3,5)P2 is involved in lysosomal dynamics and regulates ClC-7 ion channels, contributing to lysosomal pH regulation.

ELIFE (2022)

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Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor

Amy H. Ponsford et al.

Summary: Peripheral lysosomes are not less acidic compared to perinuclear lysosomes, and lysosomal pH has a certain impact on the transmission of lysosomal stress signals.

AUTOPHAGY (2021)

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Review Biochemistry & Molecular Biology

Iron and manganese transport in mammalian systems

Qingli Liu et al.

Summary: Recent studies have expanded and refined our understanding of iron and manganese transport, focusing on the roles of membrane transporters and related proteins. These studies have looked at main organs, tissues, and cell types that actively regulate whole-body iron or manganese homeostasis, emphasizing direct measurement of metal transport or use of knockout mouse models. The reviews also provide overviews of whole-body and cellular iron and manganese homeostasis to contextualize the key transporters' participation in metal uptake, intracellular trafficking, and efflux.

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Two-pore and TRPML cation channels: Regulators of phagocytosis, autophagy and lysosomal exocytosis

A. Scotto Rosato et al.

Summary: The text discusses the flow of material transport in cells, introduces the roles of TRPML channels and TPCs in intracellular movement, and their potential applications in disease treatment.

PHARMACOLOGY & THERAPEUTICS (2021)

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The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease

Amity F. Eaton et al.

Summary: The primary function of H+-ATPase is to create an electrochemical proton gradient across eukaryotic cell membranes to energize cellular processes. It acidifies intracellular vesicles and organelles for essential cell biological events. Additionally, V-ATPases play central roles in normal and pathophysiological processes that impact human health, influencing areas such as cancer, neurodegenerative diseases, and sensory perception.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2021)

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pHLARE: a new biosensor reveals decreased lysosome pH in cancer cells

Bradley A. Webb et al.

Summary: pHLARE, a genetically encoded ratiometric pHlys biosensor, has been developed to accurately measure pHlys and improve understanding of lysosome dynamics. pHlys is often increased in neurodegenerative disorders and predicted to be decreased in cancers.

MOLECULAR BIOLOGY OF THE CELL (2021)

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Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis

James Osei-Owusu et al.

Summary: The proton-activated Cl- (PAC) channel has been identified as a low pH sensor in endosomes, preventing hyper-acidification by releasing Cl- from the lumen.

CELL REPORTS (2021)

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Review Cell Biology

Endomembrane Tension and Trafficking

Amra Saric et al.

Summary: Eukaryotic cells utilize diverse uptake mechanisms for internalizing extracellular solutes and fluid into membrane-bound endosomes. After internalization, the endosomes undergo extensive remodeling involving tubulation and vesiculation, followed by maturation through retrograde transport and fusion with late endosomes and lysosomes. Control of tension on endomembranes is crucial for sorting and trafficking, with the efflux of major solutes along the endocytic pathway playing a key role in regulating membrane tension.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Tunnels for Protein Export from the Endoplasmic Reticulum

I. Raote et al.

Summary: The functions of COPII coat protein complex in eukaryotic protein secretion are conserved, but standard COPII vesicles cannot accommodate the secretion of metazoan-specific cargoes. Metazoans have evolved modules centered on proteins like TANGO1 to create a novel mode of cargo export at the endoplasmic reticulum by interacting with COPII coats and early secretory pathway membranes.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 90, 2021 (2021)

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Role of protons in calcium signaling

Giuliano Molinari et al.

Summary: This paper discusses the possible triggering role of protons during their short cellular cycle and proposes a new hypothesis for an IP3 proton-dependent mechanism of action.

BIOCHEMICAL JOURNAL (2021)

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Review Biochemistry & Molecular Biology

Two-pore and TRP cation channels in endolysosomal osmo-/mechanosensation and volume regulation

Cheng-Chang Chen et al.

Summary: TPCs and TRPML2 play crucial roles in regulating and detecting changes in surface-to-volume ratio of endolysosomes, promoting endocytic and recycling traffic. They are highly expressed in macrophages and contribute to immune cell function.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Multidisciplinary Sciences

Tubular lysosomes harbor active ion gradients and poise macrophages for phagocytosis

Bhavyashree Suresh et al.

Summary: Lysosomes can adopt dynamic, tubular states to regulate antigen presentation, phagosome resolution, and autophagy, with tubular lysosomes exhibiting different biochemical properties compared to the resting state. By using a DNA-based assembly method, lysosomes can be tubulated in macrophages, revealing lower degradative activity and specific pH and Ca2+ gradients in tubular lysosomes. This new approach of tubulating lysosomes without starving or activating immune cells may uncover novel roles for tubular lysosomes.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Cell Biology

Membrane Transport Proteins in Osteoclasts: The Ins and Outs

Amy B. P. Ribet et al.

Summary: Osteoclasts play a crucial role in bone resorption, maintaining extreme environmental conditions and coordinating the actions of various membrane transport proteins. In addition to well-known key proteins, the contributions of other membrane transport proteins to osteoclast function are still unclear.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

ER-to-Golgi protein delivery through an interwoven, tubular network extending from ER

Aubrey Weigel et al.

Summary: Cellular versatility relies on accurate trafficking of proteins to their organelles, particularly through the secretory pathway which involves an elaborate network of interconnected tubules originating from the endoplasmic reticulum. COPII protein regulates cargo entry at the ER neck region, while COPI protein escorts tubular entities towards the Golgi apparatus via microtubule-directed movement.

CELL (2021)

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Article Chemistry, Multidisciplinary

Probing Dynamic Features of Phagosome Maturation in Macrophage using Au@MnOx@SiO2 Nanoparticles as pH-Sensitive Plasmonic Nanoprobes

Jinhui Shang et al.

Summary: The multilayered Au@MnOx@SiO2 nanoparticle was developed as a robust pH-sensitive plasmonic nanosensor for real-time monitoring of dynamic acidification features during phagosome maturation process in macrophages. The color changes of nanoprobes indicated a slow-to-fast acidification translation over time, which was related to V-ATPase activation. This nanosensor shows promise for studying phagosome dysfunctions and related disease pathogenesis.

CHEMISTRY-AN ASIAN JOURNAL (2021)

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Review Biochemistry & Molecular Biology

Protein pI and Intracellular Localization

Alexander A. Tokmakov et al.

Summary: The protein isoelectric point (pI) can be calculated computationally from an amino acid sequence, and studies have shown that protein pI distributions are multimodal in different species, possibly due to differences in local pI distributions related to subcellular localization specificity.

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Association of SLC32A1 Missense Variants With Genetic Epilepsy With Febrile Seizures Plus

Sarah E. Heron et al.

Summary: By sequencing genomes of family members, eight previously unreported missense variants in SLC32A1 were identified to cause genetic epilepsy, impacting GABA transport and neuronal inhibition. Further examination of epilepsy cohorts is needed to fully understand the genotype-phenotype spectrum associated with SLC32A1 variants.

NEUROLOGY (2021)

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ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H+-ATPases is essential for brain development in humans and mice

Kazushi Aoto et al.

Summary: ATP6V0A1, a member of the vacuolar H+-ATPase family, is crucial for lysosomal activity and plays an essential role in brain development. Variants in ATP6V0A1 identified in individuals with developmental and epileptic encephalopathy are associated with impaired lysosomal acidification, autophagy, mTORC1 signaling, and ultimately affect neuronal integrity and connectivity in both humans and mice.

NATURE COMMUNICATIONS (2021)

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Imaging the electrical activity of organelles in living cells

Ella Matamala et al.

Summary: Researchers present a new optical method hVoS(org) for monitoring changes in subcellular membrane potential with advantages such as precise subcellular targeting, recording from individual organelles, and potential optical multiplexing of organellar activity.

COMMUNICATIONS BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Mitochondrial proton leaks and uncoupling proteins

David G. Nicholls

Summary: This review examines the mechanisms underlying non-shivering thermogenesis in brown adipose tissue mediated by UCP1, emphasizing the experimental evidence and physiological constraints. It also discusses the nature of endogenous proton leak and evaluates the troubled history of putative novel uncoupling proteins UCP2 and UCP3.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2021)

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SLC4A2 anion exchanger promotes tumour cell malignancy via enhancing net acid efflux across golgi membranes

Elham Khosrowabadi et al.

Summary: The proper functioning of each cell compartment relies on its specific pH micro-environment, where proton leakage across Golgi membranes is mediated by a bicarbonate-chloride exchange mechanism. This process involves a buffering reaction in the Golgi lumen, leading to the production of carbon dioxide and water for release back to the cytoplasm. Upregulation of this acid efflux pathway in cancer cells can result in elevated Golgi pH and reduced glycosylation potential.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Review Cell Biology

From the inside out: Ion fluxes at the centre of endocytic traffic

Sarah R. Chadwick et al.

Summary: The role of specific proteins and lipids in endocytic traffic has been extensively studied, but little is known about the contribution of endocytic fluid to these events. Experimental findings suggest an intimate association between luminal ions, their transport, and endocytic traffic, but mechanisms for how cells sense inorganic ions and transmit this information remain largely unknown.

CURRENT OPINION IN CELL BIOLOGY (2021)

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Melanosome Biogenesis in the Pigmentation of Mammalian Skin

Linh Le et al.

Summary: Melanins, the main pigments of the skin and hair in mammals, are synthesized within membrane-bound organelles of melanocytes called melanosomes. The structure and function of melanosomes are determined by resident transmembrane proteins, defects of which may lead to various forms of albinism. Further investigation is needed to address unanswered questions regarding the molecular mechanisms of melanosome formation and the delivery of specific components.

INTEGRATIVE AND COMPARATIVE BIOLOGY (2021)

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The V-ATPase a3 Subunit: Structure, Function and Therapeutic Potential of an Essential Biomolecule in Osteoclastic Bone Resorption

Anh Chu et al.

Summary: This review focuses on the a3 subunit of the V-ATPase complex, highlighting its critical role in bone physiology as mutations in this protein account for over 50% of osteopetrosis cases. By examining other paralogues/orthologs, it provides insights into the molecular mechanisms specific to a3. The review also explores the diverse roles of the a subunit in proton translocation, lipid binding, cell signaling, and human diseases, and discusses therapeutic implications for bone diseases and cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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The extensive and functionally uncharacterized mitochondrial phosphoproteome

Natalie M. Niemi et al.

Summary: The importance of phosphorylation within mitochondria has been widely recognized, but the majority of modifications remains poorly characterized, with disruption of mitochondrial protein phosphatases causing metabolic dysfunction. While current data suggests critical importance of mitochondrial phosphorylation, significant gaps exist in understanding how these modifications influence organellar function.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Free sialic acid storage disorder: Progress and promise

Marjan Huizing et al.

Summary: Lysosomal free sialic acid storage disorder (FSASD) is an extremely rare, autosomal recessive, neurodegenerative, multisystemic disorder caused by defects in the lysosomal sialic acid membrane exporter SLC17A5 (sialin). Clinical features include coarse facial features, organomegaly, and progressive neurodegenerative symptoms. There is no approved therapy for FSASD, and efforts are being made to develop new treatments.

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Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles

Jiyuan Zhang et al.

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ER exit sites in Drosophila display abundant ER-Golgi vesicles and pearled tubes but no megacarriers

Ke Yang et al.

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Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH

Marcus Y. Chin et al.

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Loss of the mitochondrial lipid cardiolipin leads to decreased glutathione synthesis

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Interaction between the yeast RAVE complex and Vph1-containing Vo sectors is a central glucose-sensitive interaction required for V-ATPase reassembly

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A new pH sensor localized in the Golgi apparatus of Saccharomyces cerevisiae reveals unexpected roles of Vph1p and Stv1p isoforms

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PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection

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LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function

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Interaction of the late endo-lysosomal lipid PI(3,5)P2 with the Vph1 isoform of yeast V-ATPase increases its activity and cellular stress tolerance

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Lysosomal Storage and Albinism Due to Effects of a De Novo CLCN7 Variant on Lysosomal Acidification

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Cardiolipin-induced activation of pyruvate dehydrogenase links mitochondrial lipid biosynthesis to TCA cycle function

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A recurrent missense variant in SLC9A7 causes nonsyndromic X-linked intellectual disability with alteration of Golgi acidification and aberrant glycosylation

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PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel

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A pH-sensitive luminal His-cluster promotes interaction of PAM with V-ATPase along the secretory and endocytic pathways of peptidergic cells

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LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

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Loss of the Na+/H+ exchanger NHE8 causes male infertility in mice by disrupting acrosome formation

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Direct interaction of the Golgi V-ATPase a-subunit isoform with PI(4)P drives localization of Golgi V-ATPases in yeast

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TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation

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VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses

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NATURE COMMUNICATIONS (2017)

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Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein

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High lumenal chloride in the lysosome is critical for lysosome function

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ELIFE (2017)

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Mrp Antiporters Have Important Roles in Diverse Bacteria and Archaea

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LETM1-Mediated K+ and Na+ Homeostasis Regulates Mitochondrial Ca2+ Efflux

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A Mitochondria-Targeted Ratiometric Biosensor for pH Monitoring and Imaging in Living Cells with Congo-Red-Functionalized Dual-Emission Semiconducting Polymer Dots

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The Origin and Diversification of Mitochondria

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Synchronous Bioimaging of Intracellular pH and Chloride Based on LSS Fluorescent Protein

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ACS CHEMICAL BIOLOGY (2016)

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Vacuolar H+-ATPase in the nuclear membranes regulates nucleo-cytosolic proton gradients

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Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron absorption in the mouse

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Lipid transfer and metabolism across the endolysosomal-mitochondrial boundary

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Protons Trigger Mitochondrial Flashes

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Glycosylation abnormalities in Gdt1p/TMEM165 deficient cells result from a defect in Golgi manganese homeostasis

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Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes

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The position of lysosomes within the cell determines their luminal pH

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A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair

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Endolysosomal two-pore channels regulate autophagy in cardiomyocytes

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Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System

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Endosomal Na+/H+ exchanger NHE5 influences MET recycling and cell migration

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mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells

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A Christianson syndrome-linked deletion mutation (Δ287ES288) in SLC9A6 disrupts recycling endosomal function and elicits neurodegeneration and cell death

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Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase

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Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism

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The V-ATPase membrane domain is a sensor of granular pH that controls the exocytotic machinery

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Restricted diffusion of OXPHOS complexes in dynamic mitochondria delays their exchange between cristae and engenders a transitory mosaic distribution

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Rapid Structural Changes and Acidification of Guard Cell Vacuoles during Stomatal Closure Require Phosphatidylinositol 3,5-Bisphosphate

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Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in β-cells

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Newly characterized Golgi- localized family of proteins is involved in calcium and pH homeostasis in yeast and human cells

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Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome

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A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

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Lysosomal positioning coordinates cellular nutrient responses

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Phosphorylation of Voltage-Dependent Anion Channel by Serine/Threonine Kinases Governs Its Interaction with Tubulin

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Macromolecular organization of ATP synthase and complex I in whole mitochondria

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Cardiolipin microdomains localize to negatively curved regions of Escherichia coli membranes

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mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

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Golgi apparatus casein kinase phosphorylates bioactive Ser-6 of bone morphogenetic protein 15 and growth and differentiation factor 9

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Organelle-specific expression of subunit ND5 of human complex I (NADH dehydrogenase) alters cation homeostasis in Saccharomyces cerevisiae

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Heme-binding Protein HRG-1 Is Induced by Insulin-like Growth Factor I and Associates with the Vacuolar H+-ATPase to Control Endosomal pH and Receptor Trafficking

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NHE3 Activity Is Dependent on Direct Phosphoinositide Binding at the N Terminus of Its Intracellular Cytosolic Region

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Structure of Dimeric F1F0-ATP Synthase

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PKA Regulates Vacuolar H+-ATPase Localization and Activity via Direct Phosphorylation of the A Subunit in Kidney Cells

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The Late Endosomal ClC-6 Mediates Proton/Chloride Countertransport in Heterologous Plasma Membrane Expression

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Regulation of Vacuolar Proton-translocating ATPase Activity and Assembly by Extracellular pH

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Common and Uncommon Pathogenic Cascades in Lysosomal Storage Diseases

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Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

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A cation counterflux supports lysosomal acidification

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A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism in Drosophila melanogaster photoreceptors

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The Na+/H+ Exchanger NHE6 in the Endosomal Recycling System Is Involved in the Development of Apical Bile Canalicular Surface Domains in HepG2 Cells

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Ca2+ Hot Spots on the Mitochondrial Surface Are Generated by Ca2+ Mobilization from Stores, but Not by Activation of Store-Operated Ca2+ Channels

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NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

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Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells

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Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells

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AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells

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ANNUAL REVIEW OF BIOCHEMISTRY (2009)

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

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The Vacuolar Proton Pump, V-ATPase, Is Required for Notch Signaling and Endosomal Trafficking in Drosophila

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HUMAN MOLECULAR GENETICS (2009)

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Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells

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Analysis of cardiac mitochondrial Na+-Ca2+ exchanger kinetics with a biophysical model of mitochondrial Ca2+ handing suggests a 3: 1 stoichiometry

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HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function

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The crystal structure of mouse VDAC1 at 2.3 Å resolution reveals mechanistic insights into metabolite gating

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LETM1, deleted in Wolf-Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability

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A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension

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Cytochrome c oxidase is required for the assembly/stability of respiratory complex I in mouse fibroblasts

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MOLECULAR AND CELLULAR BIOLOGY (2006)

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Control by cytochrome c oxidase of the cellular oxidative phosphorylation system depends on the mitochondrial energy state

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BIOCHEMICAL JOURNAL (2006)

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Identification of a pH sensor in the furin propeptide that regulates enzyme activation

Sylvain F. Feliciangeli et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Architecture of active mammalian respiratory chain supercomplexes

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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Subcellular pH and predicted pH-dependent features of proteins

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PROTEOMICS (2006)

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Mitochondrial membrane potential is dependent on the oligomeric state of F1F0-ATP synthase supracomplexes

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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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A shared vesicular carrier allows synaptic corelease of GABA and glycine

Sonja M. Wojcik et al.

NEURON (2006)

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Role of the Arf6 GDP/GTP cycle and Arf6 GTPase-activating proteins in actin remodeling and intracellular transport

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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Anion channels, including ClC-3, are required for normal neutrophil oxidative function, phagocytosis, and transendothelial migration

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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2006)

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A fluorescent variant of a protein from the stony coral Montipora facilitates dual-color single-laser fluorescence cross-correlation spectroscopy

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NATURE BIOTECHNOLOGY (2006)

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Review Cell Biology

ARF proteins: roles in membrane traffic and beyond

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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

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Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion

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TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity

AA Soyombo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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ClC-7 requires Ostm1 as a β-subunit to support bone resorption and lysosomal function

PF Lange et al.

NATURE (2006)

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cAMP regulates plasma membrane vacuolar-type H+-ATPase assembly and activity in blowfly salivary glands

P Dames et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Intracellular localization of ClC chloride channels and their ability to form hetero-oligomers

T Suzuki et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2006)

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Anion channels transport ATP into the Golgi lumen

RJ Thompson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)

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V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway

A Hurtado-Lorenzo et al.

NATURE CELL BIOLOGY (2006)

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BIOLOGY OF REPRODUCTION (2006)

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Rotation scheme of V1-motor is different from that of F1-motor

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Subunit a of the yeast V-ATPase participates in binding of bafilomycin

YR Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Acid acclimation by Helicobacter pylori

G Sachs et al.

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Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses

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EXTREMOPHILES (2005)

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Structure of dimeric mitochondrial ATP synthase:: Novel F0 bridging features and the structural basis of mitochondrial cristae biogenesis

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Cardiolipin is essential for organization of complexes III and IV into a supercomplex in intact yeast mitochondria

M Zhang et al.

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Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5

A Picollo et al.

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Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins

O Scheel et al.

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Review Biochemistry & Molecular Biology

The role of the phosphoinositides at the Golgi complex

MA De Matteis et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2005)

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Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection

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Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yo1027/Letm1 proteins

E Froschauer et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2005)

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Impaired acidification in early endosomes of CIC-5 deficient proximal tubule

M Hara-Chikuma et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

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Transferrin recycling and dextran transport to lysosomes is differentially affected by bafilomycin, nocodazole, and low temperature

G Baravalle et al.

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Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases

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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Differential lysosomal proteolysis in antigen-presenting CeRs determines antigen fate

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Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration

D Kasper et al.

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Immunolocalization of NHE8 in rat kidney

S Goyal et al.

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Structure of a mitochondrial supercomplex formed by respiratory-chain complexes I and III

NV Dudkina et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Review Cell Biology

Evolutionary origins of eukaryotic sodium/proton exchangers

CL Brett et al.

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pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant

AM Porcelli et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation

M Hara-Chikuma et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation

N Nakamura et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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The V-ATPase subunit C binds to polymeric F-actin as well as to monomeric G-actin and induces cross-linking of actin filaments

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Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells

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The yeast vacuolar proton-translocating ATPase contains a subunit homologous to the Manduca sexta and bovine e subunits that is essential for function

M Sambade et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Bid, but not Bax, regulates VDAC channels

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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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pH-induced conversion of the transport lectin ERGIC-53 triggers glycoprotein release

C Appenzeller-Herzog et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Article Biochemistry & Molecular Biology

The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase

M Lu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Vacuolar H+-ATPase binding to microfilaments -: Regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B

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Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels

A Accardi et al.

NATURE (2004)

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Article Biochemistry & Molecular Biology

All three isoforms of the voltage-dependent anion channel (VDAC1, VDAC2, and VDAC3) are present in mitochondria from bovine, rabbit, and rat brain

MD Cesar et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2004)

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Article Biochemistry & Molecular Biology

The intra-mitochondrial cytochrome c distribution varies correlated to the formation of a complex between VDAC and the adenine nucleotide translocase:: this affects Bax-dependent cytochrome c release

M Vyssokikh et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)

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The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis

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PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)

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LETM1, a gene deleted in Wolf-Hirschhorn syndrome, encodes an evolutionarily conserved mitochondrial protein

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The mitochondrial transporter family (SLC25): physiological and pathological implications

F Palmieri

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)

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The endoplasmic reticulum membrane is permeable to small molecules

S Le Gall et al.

MOLECULAR BIOLOGY OF THE CELL (2004)

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The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids

B Gasnier

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)

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NHE3 Na+/H+ exchanger supports proximal tubular protein reabsorption in vivo

M Gekle et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2004)

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Dimeric interaction between the cytoplasmic domains of the Na+/H+ exchanger NHE1 revealed by symmetrical intermolecular cross-linking and selective co-immunoprecipitation

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BIOCHEMISTRY (2004)

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Article Biochemistry & Molecular Biology

The mitochondrial respiratory chain is partially organized in a supercomplex assembly - Kinetic evidence using flux control analysis

C Bianchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Mycobacterium tuberculosis reprograms waves of phosphatidylinositol 3-phosphate on phagosomal organelles

J Chua et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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The peroxisomal lumen in Saccharomyces cerevisiae is alkaline

CWT van Roermund et al.

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The bafilomycin/concanamycin binding site in subunit c of the V-ATPases from Neurospora crassa and Saccharomyces cerevisiae

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The Ca2+/Mn2+ pumps in the Golgi apparatus

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)

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The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome

K Nowikovsky et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Glucose activates H+-ATPase in kidney epithelial cells

S Nakamura

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)

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Energy flux modulation on the outer membrane of mitochondria by metabolically-derived potential

SV Lemeshko et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2004)

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Functional characterization of wild-type and mutant human sialin

P Morin et al.

EMBO JOURNAL (2004)

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Control of mitochondrial motility and distribution by the calcium signal:: a homeostatic circuit

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Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology

A Zimprich et al.

NEURON (2004)

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AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells

G Salazar et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Review Nutrition & Dietetics

Mammalian zinc transporters

JP Liuzzi et al.

ANNUAL REVIEW OF NUTRITION (2004)

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The evolution of A-, F-, and V-type ATP synthases and ATPascs:: reversals in function and changes in the H+/ATP coupling ratio

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FEBS LETTERS (2004)

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Cardiolipin biosynthesis and mitochondrial respiratory chain function are interdependent

VM Gohil et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Cardiolipin stabilizes respiratory chain supercomplexes

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Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling

N Pastor-Soler et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Electrophysiological analysis of the yeast V-type proton pump: Variable coupling ratio and proton shunt

C Kettner et al.

BIOPHYSICAL JOURNAL (2003)

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Aquaporin water channels: molecular mechanisms for human diseases

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FEBS LETTERS (2003)

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Selectivity and conductance among the glycerol and water conducting aquaporin family of channels

RM Stroud et al.

FEBS LETTERS (2003)

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Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition

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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Plasticity of mitochondrial calcium signaling

G Csordás et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Interacting helical surfaces of the transmembrane segments of subunits a and c′ of the yeast V-ATPase defined by disulfide-mediated cross-linking

S Kawasaki-Nishi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Review Biochemistry & Molecular Biology

Mitochondrial potassium transport:: the K+ cycle

KD Garlid et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2003)

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The chloride channel ClC-4 contributes to endosomal acidification and trafficking

R Mohammad-Panah et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Biophysics

Subunit composition, structure, and distribution of bacterial V-type ATPases

JS Lolkema et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2003)

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Article Biochemistry & Molecular Biology

Targeting of the AE2 anion exchanger to the Golgi apparatus is cell type-dependent and correlates with the expression of Ank195, a Golgi membrane skeletal protein

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FEBS LETTERS (2003)

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Article Biochemistry & Molecular Biology

Rotation of the proteolipid ring in the V-ATPase

K Yokoyama et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Review Cell Biology

Calcium signalling: Dynamics, homeostasis and remodelling

MJ Berridge et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

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pH of TGN and recycling endosomes of H+/K+-ATPase-transfected HEK-293 cells:: implications for pH regulation in the secretory pathway

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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2003)

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The a-subunit of the V-type H+-ATPase interacts with phosphofructokinase-1 in humans

Y Su et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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A novel role for subunit C in mediating binding of the H+-V-ATPase to the actin cytoskeleton

O Vitavska et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis

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Fluorescence lifetime-resolved pH imaging of living cells

HJ Lin et al.

CYTOMETRY PART A (2003)

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Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human

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Determinants of [Cl-] in recycling and late endosomes and Golgi complex measured using fluorescent ligands

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JOURNAL OF CELL BIOLOGY (2003)

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Article Multidisciplinary Sciences

Evidence for rotation of V1-ATPase

H Imamura et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Activation of lysosomal function during dendritic cell maturation

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SCIENCE (2003)

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The PDZ-binding chloride channel ClC-3B localizes to the golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins

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The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons

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The permeability of the endoplasmic reticulum is dynamically coupled to protein synthesis

A Roy et al.

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Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2

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JOURNAL OF PHYSIOLOGY-LONDON (2003)

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The gastric Biology of Helicobactor pylori

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Green fluorescent protein variants as ratiometric dual emission pH sensors. 1. Structural characterization and preliminary application

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Structure of the LDL receptor extracellular domain at endosomal pH

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Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform -: Regulation by phosphatidylinositol 3′-kinase and the actin cytoskeleton

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Cytoprotective role of Ca2+-activated K+ channels in the cardiac inner mitochondrial membrane

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SCIENCE (2002)

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Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss

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Role of RANKL and RANK in bone loss and arthritis

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Cycling of early Golgi proteins via the cell surface and endosomes upon lumenal pH disruption

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TRAFFIC (2002)

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Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane

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NATURE (2002)

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UCP1 muscle gene transfer and mitochondrial proton leak mediated thermogenesis

E Larrarte et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2002)

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A large-conductance anion channel of the Golgi complex

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BIOPHYSICAL JOURNAL (2002)

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Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters

M Boll et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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The ClC-3 chloride channel promotes acidification of lysosomes in CHO-K1 and Huh-7 cells

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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)

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Specific modulation of Kex2/furin family proteases by potassium

NC Rockwell et al.

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Human Na+/H+ exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria

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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)

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The RAVE complex is essential for stable assembly of the yeast V-ATPase

AM Smardon et al.

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ClC-3B, a novel ClC-3 splicing variant that interacts with EBP50 and facilitates expression of CFTR-regulated ORCC

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FASEB JOURNAL (2002)

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Article Biochemistry & Molecular Biology

Determinants of the phagosomal pH in neutrophils

A Jankowski et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Article Biochemistry & Molecular Biology

Chloride concentration in endosomes measured using a ratioable fluorescent Cl- indicator -: Evidence for chloride accumulation during acidification

ND Sonawane et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Article Biochemistry & Molecular Biology

The ATP synthase is involved in generating mitochondrial cristae morphology

P Paumard et al.

EMBO JOURNAL (2002)

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Article Biophysics

Model of the outer membrane potential generation by the inner membrane of mitochondria

VV Lemeshko

BIOPHYSICAL JOURNAL (2002)

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Article Multidisciplinary Sciences

X-ray structure of a CIC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity

R Dutzler et al.

NATURE (2002)

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Article Biochemistry & Molecular Biology

In situ measurements of the pH of mammalian peroxisomes using the fluorescent protein pHluorin

A Jankowski et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Biochemistry & Molecular Biology

The amino-terminal domain of the vacuolar proton-translocating ATPase a subunit controls targeting and in vivo dissociation, and the carboxyl-terminal domain affects coupling of proton transport and ATP hydrolysis

S Kawasaki-Nishi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Multidisciplinary Sciences

Barttin is a Cl- channel β-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion

R Estévez et al.

NATURE (2001)

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Article Cell Biology

Pmel17 initiates premelanosome morphogenesis within multivesicular bodies

JF Berson et al.

MOLECULAR BIOLOGY OF THE CELL (2001)

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Article Genetics & Heredity

Mutations in the human orthologue of the mouse underwhite gene (uw) underlie a new form of oculocutaneous albinism, OCA4

JM Newton et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2001)

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Article Multidisciplinary Sciences

Arg-735 of the 100-kDa subunit a of the yeast V-ATPase is essential for proton translocation

S Kawasaki-Nishi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Review Cell Biology

The melanosome: Membrane dynamics in black and white

MS Marks et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)

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Article Cell Biology

Lumenal endosomal and Golgi-retrieval determinants involved in pH-sensitive targeting of an early Golgi protein

C Bachert et al.

MOLECULAR BIOLOGY OF THE CELL (2001)

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Review Cell Biology

The endocytic pathway: A mosaic of domains

J Gruenberg

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)

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Article Biochemistry & Molecular Biology

Citrin and aralar1 are Ca2+-stimulated aspartate/glutamate transporters in mitochondria

L Palmieri et al.

EMBO JOURNAL (2001)

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Article Biochemistry & Molecular Biology

Mechanisms of pH regulation in the regulated secretory pathway

MM Wu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Biochemistry & Molecular Biology

Interaction between aldolase and vacuolar H+ -ATPase

M Lu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Biochemistry & Molecular Biology

Propagation of the apoptotic signal by mitochondrial waves

P Pacher et al.

EMBO JOURNAL (2001)

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Article Biochemistry & Molecular Biology

Neutralization of pH in the Golgi apparatus causes redistribution of glycosyltransferases and changes in the O-glycosylation of mucins

MAB Axelsson et al.

GLYCOBIOLOGY (2001)

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Article Oncology

Melanosomal pH controls rate of melanogenesis, eumelanin/phaeomelanin ratio and melanosome maturation in melanocytes and melanoma cells

J Ancans et al.

EXPERIMENTAL CELL RESEARCH (2001)

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Article Genetics & Heredity

Mutations in the gene encoding B, a novel transporter protein, reduce melanin content in medaka

S Fukamachi et al.

NATURE GENETICS (2001)

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Review Biochemistry & Molecular Biology

Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions

JR Forbes et al.

TRENDS IN MICROBIOLOGY (2001)

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Article Biochemistry & Molecular Biology

Translocon pores in the endoplasmic reticulum are permeable to a neutral, polar molecule

D Heritage et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Multidisciplinary Sciences

Identification and characterization of a lysosomal transporter for small neutral amino acids

C Sagné et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Article Biochemistry & Molecular Biology

Identification of a novel chloride channel expressed in the endoplasmic reticulum, Golgi apparatus, and nucleus

M Nagasawa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Biochemistry & Molecular Biology

Yeast V-ATPase complexes containing different isoforms of the 100-kDa a-subunit differ in coupling efficiency and in vivo dissociation

S Kawasaki-Nishi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Biochemistry & Molecular Biology

Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes

B Maranda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Biochemistry & Molecular Biology

Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network

M Numata et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Cell Biology

Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly

JH Seol et al.

NATURE CELL BIOLOGY (2001)

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Regulation of organelle acidity

M Grabe et al.

JOURNAL OF GENERAL PHYSIOLOGY (2001)

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Inhibition of Na+-H+ exchanger-3 interferes with apical receptor-mediated endocytosis via vesicle fusion

M Gekle et al.

JOURNAL OF PHYSIOLOGY-LONDON (2001)

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Article Biochemistry & Molecular Biology

Actin modulates the gating of Neurospora crassa VDAC

X Xu et al.

JOURNAL OF MEMBRANE BIOLOGY (2001)

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Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells

G Raposo et al.

JOURNAL OF CELL BIOLOGY (2001)

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Article Cell Biology

Identification of the full-length AE2 (AE2a) isoform as the Golgi-associated anion exchanger in fibroblasts

K Holappa et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2001)

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Article Developmental Biology

Acidic endomembrane organelles are required for mouse postimplantation development

GH Sun-Wada et al.

DEVELOPMENTAL BIOLOGY (2000)

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Review Biochemistry & Molecular Biology

VDAC regulation by the Bcl-2 family of proteins

Y Tsujimoto et al.

CELL DEATH AND DIFFERENTIATION (2000)

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Article Biochemistry & Molecular Biology

The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site

LS Holliday et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Article Biochemistry & Molecular Biology

Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel

M Sun et al.

HUMAN MOLECULAR GENETICS (2000)

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Single amino acid mutations in transmembrane domain 5 confer to the plasma membrane Ca2+ pump properties typical of the Ca2+ pump of endo(sarco)plasmic reticulum

D Guerini et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Article Biophysics

The use of pHluorins for optical measurements of presynaptic activity

S Sankaranarayanan et al.

BIOPHYSICAL JOURNAL (2000)

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Evidence against the acidification hypothesis in cystic fibrosis

GA Gibson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2000)

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Review Cell Biology

The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components

R Gagescu et al.

MOLECULAR BIOLOGY OF THE CELL (2000)

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Article Biochemistry & Molecular Biology

Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function

F Jiang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Article Biochemistry & Molecular Biology

Determinants of the pH of the Golgi complex

FB Schapiro et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Article Biochemistry & Molecular Biology

The cytochrome bc1 and cytochrome c oxidase complexes associate to form a single supracomplex in yeast mitochondria

CM Cruciat et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Article Biophysics

GOLAC: An endogenous anion channel of the Golgi complex

MH Nordeen et al.

BIOPHYSICAL JOURNAL (2000)

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Article Multidisciplinary Sciences

Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival

MG Vander Heiden et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

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Article Biochemistry & Molecular Biology

Supercomplexes in the respiratory chains of yeast and mammalian mitochondria

H Schägger et al.

EMBO JOURNAL (2000)

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Article Biochemistry & Molecular Biology

Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca2+ pump

R Sudbrak et al.

HUMAN MOLECULAR GENETICS (2000)

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Article Biochemistry & Molecular Biology

Three subunit a isoforms of mouse vacuolar H+-ATPase -: Preferential expression of the a3 isoform during osteoclast differentiation

T Toyomura et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Article Biochemistry & Molecular Biology

Molecular cloning and expression of three isoforms of the 100-kDa a subunit of the mouse vacuolar proton-translocating ATPase

T Nishi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Article Cell Biology

Peroxisomes in human fibroblasts have a basic pH

TB Dansen et al.

NATURE CELL BIOLOGY (2000)

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Review Multidisciplinary Sciences

Bone resorption by osteoclasts

SL Teitelbaum

SCIENCE (2000)

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Article Genetics & Heredity

Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease

ZL Hu et al.

NATURE GENETICS (2000)

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