☆ 4.7 Review

How to get rid of itching

PHARMACOLOGY & THERAPEUTICS (2023)

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Review Biochemistry & Molecular Biology

Transient Receptor Potential Channels and Itch

Omar Mahmoud et al.

Summary: Transient Receptor Potential (TRP) channels, found abundantly in the skin, play a crucial role in the sensory pathways of itch, pain, and inflammation. This review article explores the complex physiology of different TRP channels and their involvement in modulating itch sensation and the pathophysiology of acute and chronic itch conditions. The article also highlights emerging small molecule and topical TRP channel agents as potential anti-pruritic treatments, with some advancing into clinical trials.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Biochemistry & Molecular Biology

Histamine Sensitization of the Voltage-Gated Sodium Channel Nav1.7 Contributes to Histaminergic Itch in Mice

Shaoheng Li et al.

Summary: This study demonstrates that histamine activates H1 receptors to sensitize Nav1.7 channels, leading to histamine-dependent itch.

ACS CHEMICAL NEUROSCIENCE (2022)

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Editorial Material Dermatology

Involvement of Sensory Neurone-TRPV4 in Acute and Chronic Itch Behaviours

Qiaojuan Zhang et al.

ACTA DERMATO-VENEREOLOGICA (2022)

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Article Allergy

Anti-KIT monoclonal antibody CDX-0159 induces profound and durable mast cell suppression in a healthy volunteer study

Diego Alvarado et al.

Summary: In this study, CDX-0159, an anti-KIT monoclonal antibody, was found to effectively suppress MCs and showed safety and long antibody exposure in healthy volunteers. Importantly, CDX-0159 also demonstrated dose-dependent profound suppression of plasma tryptase, indicating systemic MC suppression or ablation.

ALLERGY (2022)

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Article Dermatology

Tralokinumab plus topical corticosteroids in adults with severe atopic dermatitis and inadequate response to or intolerance of ciclosporin A: a placebo-controlled, randomized, phase III clinical trial (ECZTRA 7)

J. Gutermuth et al.

Summary: The study evaluated the efficacy and safety of tralokinumab plus TCS in adult patients with severe AD not adequately controlled with CSA or with contraindications to oral CSA, showing the treatment was effective and well tolerated.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Article Dermatology

Nemolizumab plus topical agents in patients with atopic dermatitis (AD) and moderate-to-severe pruritus provide improvement in pruritus and signs of AD for up to 68 weeks: results from two phase III, long-term studies

K. Kabashima et al.

Summary: Long-term administration of nemolizumab in patients with inadequately controlled moderate-to-severe pruritus in AD showed continuous improvement in pruritus, signs of AD, and quality of life for up to 68 weeks, with a favorable safety profile, based on two long-term phase III studies.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Article Allergy

Asivatrep, a TRPV1 antagonist, for the topical treatment of atopic dermatitis: Phase 3, randomized, vehicle-controlled study (CAPTAIN-AD)

Chun Wook Park et al.

Summary: Asivatrep cream has shown significant efficacy and good tolerability in patients with AD.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Dermatology

Circuit Mechanisms of Itch in the Brain

Di Mu et al.

Summary: Itch is an unpleasant sensation with the desire to scratch, serving as a protective mechanism to remove harmful substances from the skin. Exciting progress has been made in deciphering the mechanisms of itch, revealing key neuronal subtypes and circuits for itch transmission and modulation in the central nervous system.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

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Article Dermatology

Patient-reported outcomes from the JADE COMPARE randomized phase 3 study of abrocitinib in adults with moderate-to-severe atopic dermatitis

J. P. Thyssen et al.

Summary: Abrocitinib demonstrated significant improvements in PROs compared to placebo, with the 200 mg dose showing numerically greater effects compared to dupilumab in patients with moderate-to-severe AD.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

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Article Dermatology

Efficacy and safety of oral nalbuphine extended release in prurigo nodularis: results of a phase 2 randomized controlled trial with an open-label extension phase

E. Weisshaar et al.

Summary: The study demonstrated that oral treatment with NAL-ER 162 mg twice daily provided significant anti-pruritic efficacy in patients with PN who completed at least 10 weeks of treatment and was well tolerated. Itch reduction was more pronounced in the treatment group compared to the placebo group in subjects who completed the treatment period.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

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Review Dermatology

Novel functions of S1P in chronic itchy and inflammatory skin diseases

N. Gray et al.

Summary: S1P is a pleiotropic sphingolipid signaling molecule that influences cell fate and immune cell trafficking. Evidence suggests that dysfunction and imbalance of the S1P-axis may contribute to inflammatory skin diseases, while studies on modulators targeting the S1P pathway show promising therapeutic potential.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

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News Item Dermatology

Structural Studies of Mas-Related G Protein-Coupled Receptors

E. Lerner

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

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Review Neurosciences

Role of TRP ion channels in pruritus

Parth Shirolkar et al.

Summary: The TRP channel superfamily responds to various stimuli, including itch. Six TRP channels are involved in itch perception, primarily in the skin and dorsal root ganglia. Mutations and activations of these channels can cause discomfort and disease.

NEUROSCIENCE LETTERS (2022)

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Article Dermatology

Difamilast, a selective phosphodiesterase 4 inhibitor, ointment in paediatric patients with atopic dermatitis: a phase III randomized double-blind, vehicle-controlled trial

H. Saeki et al.

Summary: The study was a phase III randomized, double-blind, vehicle-controlled trial in Japanese pediatric patients with AD, demonstrating the superiority of topical difamilast in improving symptoms compared to vehicle.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Article Dermatology

Abrocitinib induction, randomized withdrawal, and retreatment in patients with moderate-to-severe atopic dermatitis: Results from the JAK1 Atopic Dermatitis Efficacy and Safety (JADE) REGIMEN phase 3 trial

Andrew Blauvelt et al.

Summary: The study demonstrated that most patients who continued abrocitinib treatment did not experience a flare during maintenance, and rescue treatment with abrocitinib plus topical therapy effectively restored response.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

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Article Allergy

Mechanistic insights into the antipruritic effects of lebrikizumab, an anti-IL-13 mAb

Yannick Miron et al.

Summary: These preclinical findings indicate that IL-13 plays a direct enhancer role in multiple itch and neuroactive pathways as well as transcriptional downstream effects, providing insights into the mechanistic basis for lebrikizumab's anti-itch effects.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Medicine, General & Internal

Efficacy and Safety of Difelikefalin in Japanese Patients With Moderate to Severe Pruritus Receiving Hemodialysis A Randomized Clinical Trial

Ichiei Narita et al.

Summary: This phase 2 trial suggests that 0.5 pg/kg of difelikefalin is the clinically recommended dose for treating moderate to severe pruritus in hemodialysis patients due to its efficacy, acceptable tolerability, and manageable safety profile.

JAMA NETWORK OPEN (2022)

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Review Biochemistry & Molecular Biology

Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases

Han-Bi Kim et al.

Summary: The aryl hydrocarbon receptor (AhR) is crucial for the metabolism of xenobiotics and has been found to be associated with various diseases in different organs. Recent studies have shed light on its functions in chronic inflammatory skin diseases such as atopic dermatitis (AD) and psoriasis (PS), as well as its impact on the immune system of the skin. The therapeutic effects of AhR ligands have been demonstrated, but further research is needed to fully understand the roles of AhR in chronic inflammatory skin diseases.

BIOMEDICINES (2022)

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Article Immunology

The Effects of Cannabinoid Agonist, Heat Shock Protein 90 and Nitric Oxide Synthase Inhibitors on Increasing IL-13 and IL-31 Levels in Chronic Pruritus

Zeynep Gizem Todurga Seven et al.

Summary: The study found that cannabinoid agonists and Hsp90 inhibitors can alleviate chronic itch caused by dry skin by reducing IL-13 and IL-31 levels.

IMMUNOLOGICAL INVESTIGATIONS (2022)

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Article Dermatology

Role of kappa-opioid and mu-opioid receptors in pruritus: Peripheral and central itch circuits

Brian S. Kim et al.

Summary: Modern genetic approaches have identified new neural pathways specific to itch, providing potential for drug development. Opioid receptors play a role in modulating itch, but the precise mechanisms are still being investigated. Nevertheless, several drugs have shown efficacy in clinical trials by targeting opioid receptor signaling.

EXPERIMENTAL DERMATOLOGY (2022)

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Review Immunology

Immunotargets and Therapy for Prurigo Nodularis

Angelina Labib et al.

Summary: Prurigo nodularis is a chronic inflammatory skin disease characterized by severely pruritic nodules, with treatment difficulty due to immunological dysregulation and neural amplification, and a lack of approved therapies at present.

IMMUNOTARGETS AND THERAPY (2022)

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Article Dermatology

Efficacy and patient-reported outcomes from a phase 2b, randomized clinical trial of tapinarof cream for the treatment of adolescents and adults with atopic dermatitis

Amy S. Paller et al.

Summary: Tapinarof has shown significant efficacy in treating atopic dermatitis, improving severity of eczema and affected skin area. Patients' impressions of Tapinarof were generally positive. The results indicate that Tapinarof represents a potential important advancement in topical medicine development for atopic dermatitis.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Article Dermatology

Tralokinumab plus topical corticosteroids for the treatment of moderate-to-severe atopic dermatitis: results from the double-blind, randomized, multicentre, placebo-controlled phase III ECZTRA 3 trial

J. I. Silverberg et al.

Summary: The study demonstrates that tralokinumab in combination with TCS is effective and well tolerated in patients with moderate-to-severe AD; high dose tralokinumab showed superior efficacy compared to placebo at 16 weeks. Patients who continued tralokinumab treatment at week 32 maintained response. The overall incidence of adverse events was similar across treatment groups.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Dermatology

Tralokinumab for moderate-to-severe atopic dermatitis: results from two 52-week, randomized, double-blind, multicentre, placebo-controlled phase III trials (ECZTRA 1 and ECZTRA 2)

A. Wollenberg et al.

Summary: Tralokinumab monotherapy was found to be superior to placebo at 16 weeks of treatment in two 52-week phase III trials, ECZTRA 1 and ECZTRA 2, and was well tolerated up to 52 weeks of treatment with sustained efficacy.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Allergy

Novel insights into the TRPV3-mediated itch in atopic dermatitis

Ciara Larkin et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Allergy

Mast Cell-Specific MRGPRX2: a Key Modulator of Neuro-Immune Interaction in Allergic Diseases

Monica Thapaliya et al.

Summary: Recent research has identified a potential link between atopic dermatitis and allergic asthma with Mas-related G protein-coupled receptor-X2 (MRGPRX2), suggesting that this receptor plays a key role in the pathogenesis of AD and allergic asthma.

CURRENT ALLERGY AND ASTHMA REPORTS (2021)

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Review Dermatology

Cannabinoids interaction with transient receptor potential family and implications in the treatment of rosacea

Kieran B. Garbutcheon-Singh et al.

Summary: With the recent interest in medical marijuana, research into cannabinoids is regaining wider attention. Cannabinoids are known to modulate cutaneous inflammation, pain, and itch by acting on different receptors. Rosacea may be associated with transient receptor potential ion channels, and cannabinoids may play a potential role in treating rosacea by affecting these pathways.

DERMATOLOGIC THERAPY (2021)

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Letter Dermatology

Cutaneous Gene Expression in Primates with Itch

Leigh A. Nattkemper et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Letter Dermatology

Neurokinin-1 receptor antagonist tradipitant has mixed effects on itch in atopic dermatitis: results from EPIONE, a randomized clinical trial

S. E. Welsh et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

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Review Dermatology

Periostin, an Emerging Player in Itch Sensation

Takashi Hashimoto et al.

Summary: Periostin plays a role in amplifying T helper type 2 immune responses in allergic inflammation, and is also involved in itch sensation by directly stimulating nerve fibers and interacting with immune and nonimmune cells.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Pharmacology & Pharmacy

A plant-derived TRPV3 inhibitor suppresses pain and itch

Yalan Han et al.

Summary: Citrusinine-II, an acridone alkaloid isolated from Atalantia monophylla, was found to selectively inhibit the TRPV3 channel with potential efficacy in alleviating both chronic and acute itch. It also showed significant analgesic effects with minimal side effects, making it a promising candidate for the development of anti-pruritus drugs.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Medicine, General & Internal

Phase 3 Trials of Tapinarof Cream for Plaque Psoriasis

Mark G. Lebwohl et al.

Summary: Tapinarof cream used once daily was more effective in reducing the severity of plaque psoriasis over 12 weeks compared to vehicle control, but was associated with local adverse events and headache. Larger and longer trials are needed to evaluate the efficacy and safety of tapinarof cream.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Allergy

A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice

Katharina Wolf et al.

Summary: Mas gene-related G protein-coupled receptors (MRGPRs) play a fundamental role in pain and itch sensation, with MRGPRX2 and its murine orthologue MRGPRB2 mediating pseudoallergic drug reactions. The study identified a class of commonly used drugs that activate MRGPRX2, primarily consisting of cationic amphiphilic drugs, leading to degranulation of mast cells and scratching behavior in both human and mice models. This research contributes to understanding the structure-activity relationships and functionality of MRGPRX2 ligands to predict and prevent adverse reactions such as drug-induced pruritus.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Allergy

Biologics for the Use in Chronic Spontaneous Urticaria: When and Which

Marcus Maurer et al.

Summary: The guidelines recommend the use of omalizumab in antihistamine-refractory CSU, highlighting the key role of IgE and FcεRI in the pathogenesis. The review covers mechanisms of action, biomarkers, and strategies for improving treatment efficacy, as well as exploring off-label use of other biologics. Future directions include novel biologics targeting various pathways in CSU treatment.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Article Veterinary Sciences

Polyphenols and Cannabidiol Modulate Transcriptional Regulation of Th1/Th2 Inflammatory Genes Related to Canine Atopic Dermatitis

Marcella Massimini et al.

Summary: By using a novel in vitro model of AD, researchers attempted to reverse the altered transcriptional regulation of key genes associated with canine atopic dermatitis using a nutraceutical mixture. The results showed a significant downregulation of gene expression in inflamed cells and an increase in DNA methylation at specific CpG sites, laying the groundwork for potential use in veterinary medicine and deeper understanding of the mechanisms of action.

FRONTIERS IN VETERINARY SCIENCE (2021)

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Article Dermatology

Patient-Reported Symptoms and Disease Impacts in Adults With Moderate-to-Severe Atopic Dermatitis: Results From a Phase 2b Study With Abrocitinib

Eric L. Simpson et al.

Summary: Abrocitinib treatment resulted in rapid and persistent improvements in symptoms and impacts of atopic dermatitis in moderate-to-severe disease patients.

DERMATITIS (2021)

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Article Pharmacology & Pharmacy

Targeting Sphingosine-1-Phosphate Signaling in Immune-Mediated Diseases: Beyond Multiple Sclerosis

Tamara Perez-Jeldres et al.

Summary: Sphingosine-1-phosphate (S1P) acts through 5 G-protein-coupled receptors to regulate lymphocyte trafficking and is involved in the pathogenesis of immune-mediated diseases. Modulators of S1P receptors have shown promise in treating diseases like multiple sclerosis and are being evaluated for other immune-related conditions.

DRUGS (2021)

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Editorial Material Biochemistry & Molecular Biology

Psoriasis: Pathogenesis, Comorbidities, and Therapy Updated

Naoko Kanda

Summary: Psoriasis is a chronic inflammatory skin disease characterized by abnormal immune responses, hyperproliferation of keratinocytes, and comorbidities such as arthritis and cardiometabolic diseases. Recent research has uncovered potential biomarkers, therapeutic targets, and treatment options for psoriasis. Understanding the pathogenesis and treatment of psoriasis may lead to new approaches and therapies in the future.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

The Role of TRPA1 in Skin Physiology and Pathology

Roberto Maglie et al.

Summary: TRPA1, a member of the TRP superfamily, plays a crucial role in sensory neurons and has been found to be expressed in various skin cells, contributing to skin physiology and pathophysiology. Recent studies have highlighted the potential use of TRPA1 antagonists in the treatment of inflammatory and immunological skin disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell Biology

Therapeutic Potential of MRGPRX2 Inhibitors on Mast Cells

Hiroyuki Ogasawara et al.

Summary: Mast cells play a key role in inflammatory and allergic reactions by releasing intracellular inflammatory mediators. Both IgE-dependent and -independent pathways contribute to mast cell activation, with recent studies highlighting the importance of receptors like MRGPRX2 in regulating this process and potential therapeutic interventions for allergic and inflammatory diseases.

CELLS (2021)

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Review Medicine, General & Internal

Atopic Dermatitis

Sonja Staender

Summary: Atopic dermatitis is a chronic condition that typically begins in childhood and can persist into adulthood, with treatment options including both topical and systemic approaches targeting the underlying immune condition.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Abrocitinib versus Placebo or Dupilumab for Atopic Dermatitis

Thomas Bieber et al.

Summary: The study demonstrated that both 200 mg and 100 mg doses of abrocitinib showed significant efficacy in treating moderate-to-severe atopic dermatitis compared to placebo, with the 200 mg dose being superior to dupilumab in improving itch response. Neither dose of abrocitinib showed significant differences from dupilumab in most other key secondary endpoints at week 16.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Dermatology

Association of Wildfire Air Pollution and Health Care Use for Atopic Dermatitis and Itch

Raj P. Fadadu et al.

Summary: This study found that short-term exposure to air pollution from wildfires was associated with increased healthcare use for patients with AD and itch, providing a better understanding of the association between poor air quality and skin health and guiding healthcare professionals in counseling patients with skin diseases and public health practices.

JAMA DERMATOLOGY (2021)

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Review Immunology

Pruritus as a Distinctive Feature of Type 2 Inflammation

Simone Garcovich et al.

Summary: Research has shown that inflammation and immune responses play an important role in the pathogenesis of chronic pruritic skin diseases, with the release of specific cytokines being the main regulators of chronic itch. Skin diseases such as atopic dermatitis and scabies are associated with the most severe pruritus, while in other conditions, type 2 inflammation is less represented and pruritus is milder.

VACCINES (2021)

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Article Dermatology

Rapid Improvement of Itch Associated With Atopic Dermatitis With Abrocitinib Is Partially Independent of Overall Disease Improvement: Results From Pooled Phase 2b and 3 Monotherapy Studies

Brian S. Kim et al.

Summary: The study demonstrated that abrocitinib significantly relieved itch in moderate to severe atopic dermatitis patients, with improvements in sleep and quality of life. The antipruritic effects of abrocitinib were independent of baseline itch severity, sex, race, body mass index, or overall disease improvement, suggesting a unique mechanism of action.

DERMATITIS (2021)

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Article Dermatology

The pruritogenic role of the type 2 immune response in diseases associated with chronic itch

Giuseppe Ingrasci et al.

Summary: While the etiologies of chronic pruritus are diverse, recent research suggests that there are similar interactions between keratinocytes, nerves, and the immune system in many conditions. The type 2 immune response, involving Th2 T Cells and related cytokines, plays a significant role in the development of pruritus in various itchy conditions. Atopic dermatitis is a prominent example, but the evidence supporting its role in other itchy conditions is growing, with new treatments targeting this immune system pathway being developed.

EXPERIMENTAL DERMATOLOGY (2021)

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Review Allergy

JAK inhibitors in the treatment of atopic dermatitis

Raj Chovatiya et al.

Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disorder with limited treatment options. Recent studies have shown that both topical and systemic Janus kinase (JAK) inhibitors hold promise in treating AD, with further research needed to fully understand their efficacy and safety.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Dermatology

28588 Efficacy and safety of roflumilast foam 0.3% in patients with seborrheic dermatitis in a randomized, double-blind, vehicle-controlled phase 2 study

Matthew Zirwas et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Article Dermatology

27874 Correlation of itch response to roflumilast cream with disease severity and patient-reported outcomes in patients with chronic plaque psoriasis

Linda Stein Gold et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Article Dermatology

26622 The impact of neuropathic itch on patients’ quality of life

Zoe M. Lipman et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Article Medicine, General & Internal

Approach to the Patient with Chronic Pruritus

Zoe M. Lipman et al.

MEDICAL CLINICS OF NORTH AMERICA (2021)

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Article Dermatology

Efficacy and Safety of Abrocitinib in Combination With Topical Therapy in Adolescents With Moderate-to-Severe Atopic Dermatitis The JADE TEEN Randomized Clinical Trial

Lawrence F. Eichenfield et al.

Summary: The study found that oral abrocitinib combined with topical therapy was significantly more effective than placebo with topical therapy in adolescents with moderate-to-severe AD, with an acceptable safety profile.

JAMA DERMATOLOGY (2021)

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Article Biochemistry & Molecular Biology

TRPV1 and TRPA1 Channels Are Both Involved Downstream of Histamine-Induced Itch

Jenny Wilzopolski et al.

Summary: The study found that both TRPV1 and TRPA1 channels play important roles in the transmission of histamine-induced itch, with TRPV1 inhibition reducing itch induced by both H1R and H4R, while TRPA1 inhibition only reduced H4R-induced itch. In vitro experiments showed that inhibition of TRPV1 and TRPA1 led to reduced Ca2+ influx into sensory neurons.

BIOMOLECULES (2021)

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Review Immunology

The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development

Kazufumi Kunimura et al.

Summary: Atopic dermatitis is a prevalent chronic inflammatory skin disease, with IL-31 as a key mediator of AD-related itch. EPAS1 and NKB have been identified as critical molecules for IL-31 production and transmission of itch, potentially serving as novel drug targets for AD-associated itch.

INTERNATIONAL IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Structure, function and pharmacology of human itch GPCRs

Can Cao et al.

Summary: Structural studies of MRGPRX2 and MRGPRX4 in complex with endogenous and synthetic ligands provide insights for developing therapeutic compounds for pain, itch, and mast cell-mediated hypersensitivity. These receptors are key mediators of itch and related mast cell-mediated hypersensitivity reactions.

NATURE (2021)

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Article Dermatology

Pathophysiologic mechanisms of itch in bullous pemphigoid

Takashi Hashimoto et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Article Allergy

Phase 2B randomized study of nemolizumab in adults with moderate-to-severe atopic dermatitis and severe pruritus

Jonathan Silverberg et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Dermatology

Phase 2 trial of a neurokinin-1 receptor antagonist for the treatment of chronic itch in patients with epidermolysis bullosa: A randomized clinical trial

Albert S. Chiou et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Article Dermatology

Phase 2, randomized, double-blind, placebo-controlled, 4-week study to evaluate the safety and efficacy of OPA-15406 (difamilast), a new topical selective phosphodiesterase type-4 inhibitor, in Japanese pediatric patients aged 2-14 years with atopic dermatitis

Hidehisa Saeki et al.

JOURNAL OF DERMATOLOGY (2020)

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Article Dermatology

Mechanisms of Itch in Stasis Dermatitis: Significant Role of IL-31 from Macrophages

Takashi Hashimoto et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

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Review Medicine, Research & Experimental

Role of macrophage TRPV4 in inflammation

Bidisha Dutta et al.

LABORATORY INVESTIGATION (2020)

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Article Medicine, General & Internal

A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus

Steven Fishbane et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Dermatology

PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes

Jiahui Zhao et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

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Article Dermatology

Serlopitant for psoriatic pruritus: A phase 2 randomized, double-blind, placebo-controlled clinical trial

David M. Pariser et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Review Dermatology

Cannabinoids for the treatment of chronic pruritus: A review

Christina Avila et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Article Dermatology

Dupilumab treatment results in early and sustained improvements in itch in adolescents and adults with moderate to severe atopic dermatitis: Analysis of the randomized phase 3 studies SOLO 1 and SOLO 2, AD ADOL, and CHRONOS

Jonathan I. Silverberg et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Article Medicine, General & Internal

Trial of Nemolizumab in Moderate-to-Severe Prurigo Nodularis

Sonja Staender et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

Tissue-resident macrophages can be generated de novo in adult human skin from resident progenitor cells during substance P-mediated neurogenic inflammation ex vivo

Jennifer Gherardini et al.

PLOS ONE (2020)

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Article Dermatology

Efficacy and Safety of Lebrikizumab, a High-Affinity Interleukin 13 Inhibitor, in Adults With Moderate to Severe Atopic Dermatitis A Phase 2b Randomized Clinical Trial

Emma Guttman-Yassky et al.

JAMA DERMATOLOGY (2020)

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Article Dermatology

Enhanced Thermal Sensitivity of TRPV3 in Keratinocytes Underlies Heat-Induced Pruritogen Release and Pruritus in Atopic Dermatitis

Seong Hoon Seo et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

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Article Cell Biology

Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch

Santosh K. Mishra et al.

CELL REPORTS (2020)

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Article Dermatology

Efficacy and Safety of Abrocitinib in Patients With Moderate-to-Severe Atopic Dermatitis A Randomized Clinical Trial

Jonathan Silverberg et al.

JAMA DERMATOLOGY (2020)

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Article Dermatology

Safety, tolerability and efficacy of repeated intravenous infusions of KHK4083, a fully human anti-OX40 monoclonal antibody, in Japanese patients with moderate to severe atopic dermatitis

Hidemi Nakagawa et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2020)

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Article Urology & Nephrology

Randomized Controlled Trial of Difelikefalin for Chronic Pruritus in Hemodialysis Patients

Steven Fishbane et al.

KIDNEY INTERNATIONAL REPORTS (2020)

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Article Medicine, General & Internal

Efficacy and safety of abrocitinib in adults and adolescents with moderate-to-severe atopic dermatitis (JADE MONO-1): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial

Eric L Simpson et al.

LANCET (2020)

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Article Anesthesiology

Antinociceptive, reinforcing, and pruritic effects of the G-protein signalling-biased mu opioid receptor agonist PZM21 in non-human primates

Huiping Ding et al.

BRITISH JOURNAL OF ANAESTHESIA (2020)

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Article Medicine, General & Internal

Trial of Nemolizumab and Topical Agents for Atopic Dermatitis with Pruritus

Kenji Kabashima et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Multidisciplinary Sciences

Central circuit mechanisms of itch

Xiao-Jun Chen et al.

NATURE COMMUNICATIONS (2020)

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Article Immunology

Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens

Caroline Perner et al.

IMMUNITY (2020)

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Letter Medicine, General & Internal

Benralizumab for Chronic Spontaneous Urticaria

Jonathan A. Bernstein et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Letter Public, Environmental & Occupational Health

Evaluation of apremilast in chronic pruritus of unknown origin: A proof-of-concept, phase 2a, open-label, single-arm clinical trial

Marie Clark et al.

HEALTH SCIENCE REPORTS (2020)

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Article Dermatology

The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis

Julie Sophie Hohwu Elsner et al.

ACTA DERMATO-VENEREOLOGICA (2020)

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Review Dermatology

Possible roles of basophils in chronic itch

Takashi Hashimoto et al.

EXPERIMENTAL DERMATOLOGY (2019)

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Article Dermatology

A phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of atopic dermatitis

Johnny Peppers et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

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Article Allergy

GBR 830, an anti-OX40, improves skin gene signatures and clinical scores in patients with atopic dermatitis

Emma Guttman-Yassky et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Dermatology

Serlopitant reduced pruritus in patients with prurigo nodularis in a phase 2, randomized, placebo-controlled trial

Sonja Staender et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

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Article Anesthesiology

Effect of adding nalbuphine to intrathecal bupivacaine with morphine on postoperative nausea and vomiting and pruritus after elective cesarean delivery: a randomized double blinded study

Abdelrady S. Ibrahim et al.

MINERVA ANESTESIOLOGICA (2019)

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Article Neurosciences

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain

Dustin P. Green et al.

NEURON (2019)

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Review Allergy

Periostin: An emerging biomarker for allergic diseases

Kenji Izuhara et al.

ALLERGY (2019)

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Review Dermatology

Substance P and neurokinin 1 receptor are new targets for the treatment of chronic pruritus

S. Staender et al.

BRITISH JOURNAL OF DERMATOLOGY (2019)

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Article Immunology

Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch

James Meixiong et al.

IMMUNITY (2019)

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Article Multidisciplinary Sciences

MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus

James Meixiong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Biology

MRGPRX4 is a bile acid receptor for human cholestatic itch

Huasheng Yu et al.

ELIFE (2019)

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Letter Dermatology

Interleukin-4 and interleukin-13 evoke scratching behaviour in mice

Michelle Campion et al.

EXPERIMENTAL DERMATOLOGY (2019)

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Article Biochemistry & Molecular Biology

3′-O-Methylorobol Inhibits the Voltage-Gated Sodium Channel Nav1.7 with Anti-Itch Efficacy in A Histamine-Dependent Itch Mouse Model

Fan Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Immunology

House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation

Nadine Serhan et al.

NATURE IMMUNOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects

Navin Goyal et al.

AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS (2019)

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Article Dermatology

Efficacy and Safety of Oral Janus Kinase 1 Inhibitor Abrocitinib for Patients With Atopic Dermatitis A Phase 2 Randomized Clinical Trial

Melinda J. Gooderham et al.

JAMA DERMATOLOGY (2019)

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Article Dermatology

Efficacy and safety of PAC-14028 cream - a novel, topical, nonsteroidal, selective TRPV1 antagonist in patients with mild-to-moderate atopic dermatitis: a phase IIb randomized trial

Y. W. Lee et al.

BRITISH JOURNAL OF DERMATOLOGY (2019)

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Article Allergy

Role of P2X3 receptors in scratching behavior in mouse models

Miho Shiratori-Hayashi et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Dermatology

A Phase 2 Randomized Trial of Apremilast in Patients with Atopic Dermatitis

Eric L. Simpson et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

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Article Biology

Identification of a bilirubin receptor that may mediate a component of cholestatic itch

James Meixiong et al.

ELIFE (2019)

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Letter Allergy

Dupilumab as a novel therapy for difficult to treat chronic spontaneous urticaria

Jason Kihyuk Lee et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

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Article Dermatology

Antipruritic Effects of Janus Kinase Inhibitor Tofacitinib in a Mouse Model of Psoriasis

Takashi Hashimoto et al.

ACTA DERMATO-VENEREOLOGICA (2019)

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Review Neurosciences

Regulation of Pain and Itch by TRP Channels

Carlene Moore et al.

NEUROSCIENCE BULLETIN (2018)

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Article Dermatology

Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor

Gil Yosipovitch et al.

ACTA DERMATO-VENEREOLOGICA (2018)

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Article Dermatology

Role of Substance P and Its Receptor Neurokinin 1 in Chronic Prurigo: A Randomized, Proof-of-Concept, Controlled Trial with Topical Aprepitant

Tatevik Ohanyan et al.

ACTA DERMATO-VENEREOLOGICA (2018)

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Article Dermatology

Involvement of spinal cannabinoid receptors in the antipruritic effects of WIN 55,212-2, a cannabinoid receptor agonist

K. A. Bilir et al.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2018)

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Review Immunology

Role of mast cells and basophils in pruritus

Martin Steinhoff et al.

IMMUNOLOGICAL REVIEWS (2018)

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Letter Dermatology

Anti-pruritic efficacies of doxycycline and erythromycin in the treatment of acne vulgaris: A randomized single-blinded pilot study

Taige Cao et al.

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY (2018)

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Article Allergy

Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch

Jialie Luo et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Article Dermatology

The Genetics of Chronic Itch: Gene Expression in the Skin of Patients with Atopic Dermatitis and Psoriasis with Severe Itch

Leigh A. Nattkemper et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

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Article Chemistry, Medicinal

Identification of N-{cis-3-(Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)aminolcyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases

Michael L. Vazquez et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

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Letter Health Care Sciences & Services

Prevalence and Characteristics of Pruritus and Association With Quality of Life in People Living With HIV: A Cross-Sectional Study

Thomas Xu et al.

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT (2018)

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Article Dermatology

Phosphodiesterase 4 inhibitors

Rema Zebda et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

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Article Dermatology

Serlopitant for the treatment of chronic pruritus: Results of a randomized, multicenter, placebo-controlled phase 2 clinical trial

Gil Yosipovitch et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

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Article Dermatology

Efficacy and safety of lebrikizumab (an anti-IL-13 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical corticosteroids: A randomized, placebo-controlled phase II trial (TREBLE)

Eric L. Simpson et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

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Article Neurosciences

miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus

Qingjian Han et al.

NEURON (2018)

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Review Anesthesiology

Alloknesis and hyperknesis-mechanisms, assessment methodology, and clinical implications of itch sensitization

Hjalte Holm Andersen et al.

PAIN (2018)

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Review Food Science & Technology

Antipruritic Effects of Botulinum Neurotoxins

Parisa Gazerani

TOXINS (2018)

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Article Biology

Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling

Francie Moehring et al.

ELIFE (2018)

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Article Multidisciplinary Sciences

Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation

Helvira Melo et al.

SCIENTIFIC REPORTS (2018)

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Review Allergy

Itch: From mechanism to (novel) therapeutic approaches

Gil Yosipovitch et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Article Chemistry, Multidisciplinary

A pivotal role for the activation of TRPV3 channel in itch sensations induced by the natural skin sensitizer carvacrol

Ting-ting Cui et al.

ACTA PHARMACOLOGICA SINICA (2018)

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Review Chemistry, Medicinal

TRP Channels as Drug Targets to Relieve Itch

Zili Xie et al.

PHARMACEUTICALS (2018)

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Article Respiratory System

Upregulation of Mas-related G Protein coupled receptor X2 in asthmatic lung mast cells and its activation by the novel neuropeptide hemokinin-1

Wichayapha Manorak et al.

RESPIRATORY RESEARCH (2018)

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Letter Dermatology

Efficacy of a topical proteinase-activated receptor-2 inhibitor on cowhage-induced pruritus: a randomized placebo-controlled double-blind study

T. Cao et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2017)

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Article Immunology

The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin

Takanori Hidaka et al.

NATURE IMMUNOLOGY (2017)

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Article Neurosciences

Antioxidants Attenuate Acute and Chronic Itch: Peripheral and Central Mechanisms of Oxidative Stress in Pruritus

Feng-Ming Zhou et al.

NEUROSCIENCE BULLETIN (2017)

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Article Allergy

Substance P activates Mas-related G protein-coupled receptors to induce itch

Ehsan Azimi et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Allergy

Synergistic antipruritic effects of gamma aminobutyric acid A and B agonists in a mouse model of atopic dermatitis

Ferda Cevikbas et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Review Immunology

Role of Substance P Neuropeptide in Inflammation, Wound Healing, and Tissue Homeostasis

Susmit Suvas

JOURNAL OF IMMUNOLOGY (2017)

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Article Dermatology

Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans

Susan H. Smith et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

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Article Chemistry, Medicinal

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Russell F. Graceffa et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

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Article Medicine, Research & Experimental

Up-regulated expression of substance P in CD8+ T cells and NK1R on monocytes of atopic dermatitis

Zenan Zhang et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

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Article Biochemistry & Molecular Biology

In silico design of novel probes for the atypical opioid receptor MRGPRX2

Katherine Lansu et al.

NATURE CHEMICAL BIOLOGY (2017)

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Review Allergy

The molecular and cellular mechanisms of itch and the involvement of TRP channels in the peripheral sensory nervous system and skin

Hiroki Kittaka et al.

ALLERGOLOGY INTERNATIONAL (2017)

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Article Urology & Nephrology

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Nalbuphine ER Tablets for Uremic Pruritus

Vandana S. Mathur et al.

AMERICAN JOURNAL OF NEPHROLOGY (2017)

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Article Biochemistry & Molecular Biology

Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch

Landon K. Oetjen et al.

CELL (2017)

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Article Chemistry, Medicinal

Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice

Anthony J. Roecker et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

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Review Allergy

Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?

Nicholas K. Mollanazar et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2016)

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Review Anesthesiology

The pathogenesis of Prurigo nodularis - Super-Itch' in exploration

C. Zeidler et al.

EUROPEAN JOURNAL OF PAIN (2016)

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Article Dermatology

Cutaneous T-cell Lymphoma and Pruritus: The Expression of IL-31 and its Receptors in the Skin

Leigh A. Nattkemper et al.

ACTA DERMATO-VENEREOLOGICA (2016)

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Article Dermatology

Effects of Apremilast on Pruritus and Skin Discomfort/Pain Correlate With Improvements in Quality of Life in Patients With Moderate to Severe Plaque Psoriasis

Jeffrey M. Sobell et al.

ACTA DERMATO-VENEREOLOGICA (2016)

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Article Dermatology

Pathophysiology of pruritus in primary localized cutaneous amyloidosis

H. L. Tey et al.

BRITISH JOURNAL OF DERMATOLOGY (2016)

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Article Health Care Sciences & Services

Health-related quality of life in haemodialysis patients suffering from chronic itch: results from GEHIS (German Epidemiology Haemodialysis Itch Study)

Melanie Weiss et al.

QUALITY OF LIFE RESEARCH (2016)

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Article Pathology

Histamine Released from Epidermal Keratinocytes Plays a Role in α-Melanocyte-Stimulating Hormone-Induced Itching in Mice

Kyoko Shimizu et al.

AMERICAN JOURNAL OF PATHOLOGY (2015)

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Article Immunology

Improved pruritus correlates with lower levels of IL-31 in CTCL patients under different therapeutic modalities

Filiberto Cedeno-Laurent et al.

CLINICAL IMMUNOLOGY (2015)

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Article Dermatology

Health-Related Quality of Life in Chronic Pruritus: An Analysis Related to Disease Etiology, Clinical Skin Conditions and Itch Intensity

Benjamin Warlich et al.

DERMATOLOGY (2015)

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Article Dermatology

A putative antipruritic mechanism of the phosphodiesterase-4 inhibitor E6005 by attenuating capsaicin-induced depolarization of C-fibre nerves

Hisashi Wakita et al.

EXPERIMENTAL DERMATOLOGY (2015)

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Article Dermatology

Topical cannabinoid receptor 1 agonist attenuates the cutaneous inflammatory responses in oxazolone-induced atopic dermatitis model

Hyun Jong Kim et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2015)

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Article Dermatology

The Psychological Burden of Skin Diseases: A Cross-Sectional Multicenter Study among Dermatological Out-Patients in 13 European Countries

Florence J. Dalgard et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

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Article Pharmacology & Pharmacy

S-777469, a Novel Cannabinoid Type 2 Receptor Agonist, Suppresses Itch-Associated Scratching Behavior in Rodents through Inhibition of Itch Signal Transmission

Takayo Haruna et al.

PHARMACOLOGY (2015)

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Article Pathology

Expression of Periostin in Normal, Atopic, and Nonatopic Chronically Inflamed Canine Skin

T. Mineshige et al.

VETERINARY PATHOLOGY (2015)

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Article Multidisciplinary Sciences

Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates

Heeseung Lee et al.

SCIENTIFIC REPORTS (2015)

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Article Dermatology

Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis

Yoko Murata et al.

JOURNAL OF DERMATOLOGY (2015)

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Article Multidisciplinary Sciences

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

Benjamin D. McNeil et al.

NATURE (2015)

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Review Biochemistry & Molecular Biology

TRP Channel Cannabinoid Receptors in Skin Sensation, Homeostasis, and Inflammation

Michael J. Caterina

ACS CHEMICAL NEUROSCIENCE (2014)

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Review Dermatology

Role of AhR/ARNT system in skin homeostasis

Masutaka Furue et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2014)

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Review Clinical Neurology

The neurology of itch

Amar Dhand et al.

BRAIN (2014)

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Review Dermatology

Itch and nerve fibers with special reference to atopic dermatitis: Therapeutic implications

Mitsutoshi Tominaga et al.

JOURNAL OF DERMATOLOGY (2014)

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Letter Dermatology

Substance P Is Upregulated in the Serum of Patients with Chronic Spontaneous Urticaria

Martin Metz et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

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Article Anesthesiology

Paroxysmal itch caused by gain-of-function Nav1.7 mutation

Grazia Devigili et al.

PAIN (2014)

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Article Geriatrics & Gerontology

N-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patients

Chao Yuan et al.

CLINICAL INTERVENTIONS IN AGING (2014)

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Article Pharmacology & Pharmacy

The Histamine H4 Receptor Antagonist, JNJ 39758979, Is Effective in Reducing Histamine-Induced Pruritus in a Randomized Clinical Study in Healthy Subjects

Alexa Kollmeier et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)

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Review Pharmacology & Pharmacy

The role of histamine in neurogenic inflammation

A. C. Rosa et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

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Article Biochemistry & Molecular Biology

The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

Sarah R. Wilson et al.

CELL (2013)

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Article Medicine, General & Internal

Chronic Pruritus

Gil Yosipovitch et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Endocrinology & Metabolism

Keratinocytes express cytokines and nerve growth factor in response to neuropeptide activation of the ERK1/2 and JNK MAPK transcription pathways

Xiaoyou Shi et al.

REGULATORY PEPTIDES (2013)

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Article Genetics & Heredity

Exome Sequencing Reveals Mutations in TRPV3 as a Cause of Olmsted Syndrome

Zhimiao Lin et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2012)

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Article Pharmacology & Pharmacy

Apremilast mechanism of action and application to psoriasis and psoriatic arthritis

Peter Schafer

BIOCHEMICAL PHARMACOLOGY (2012)

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Article Chemistry, Medicinal

Discovery of S-777469: An orally available CB2 agonist as an antipruritic agent

Masahide Odan et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

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Article Critical Care Medicine

The use of botulinum toxin in the management of burns itching: Preliminary results

N. Akhtar et al.

BURNS (2012)

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Article Medicine, Research & Experimental

Periostin promotes chronic allergic inflammation in response to Th2 cytokines

Miho Masuoka et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

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Article Neurosciences

Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate

Steve Davidson et al.

JOURNAL OF NEUROPHYSIOLOGY (2012)

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Article Neurosciences

A tale of two itches. Common features and notable differences in brain activation evoked by cowhage and histamine induced itch

Alexandru D. P. Papoiu et al.

NEUROIMAGE (2012)

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Review Immunology

Protease-activated receptor 2 signaling in inflammation

Andrea S. Rothmeier et al.

SEMINARS IN IMMUNOPATHOLOGY (2012)

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Article Neurosciences

Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice

Tong Liu et al.

NEUROSCIENCE BULLETIN (2012)

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Article Dermatology

Expression of tachykinins and their receptors in plaque psoriasis with pruritus

B. Amatya et al.

BRITISH JOURNAL OF DERMATOLOGY (2011)

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Article Pharmacology & Pharmacy

G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: Roles of Mas-related genes MrgX1 and MrgX2

Sakeen W. Kashem et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2011)

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Article Microbiology

Tetracyclines Modulate Protease-Activated Receptor 2-Mediated Proinflammatory Reactions in Epidermal Keratinocytes

Chika Ishikawa et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)

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Article Dermatology

Botulinum toxin type A reduces histamine-induced itch and vasomotor responses in human skin

P. Gazerani et al.

BRITISH JOURNAL OF DERMATOLOGY (2009)

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Article Immunology

Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

Anais Briot et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)

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Article Cell Biology

Periostin localizes to cells in normal skin, but is associated with the extracellular matrix during wound repair

Linda Jackson-Boeters et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2009)

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Article Neurosciences

TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase

Won-Sik Shim et al.

JOURNAL OF NEUROSCIENCE (2007)

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Article Dermatology

Substance P receptor expression in human skin keratinocytes and fibroblasts

J. -Y. Liu et al.

BRITISH JOURNAL OF DERMATOLOGY (2006)

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Article Endocrinology & Metabolism

Effects of the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide and galanin on the production of nerve growth factor and inflammatory cytokines in cultured human keratinocytes

Attila Dallos et al.

NEUROPEPTIDES (2006)

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Article Biochemistry & Molecular Biology

Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions

M Tauchi et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

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Article Multidisciplinary Sciences

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin

M Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Letter Hematology

Emollients with endocannabinoids in the treatment of uremic pruritus: Discussion of the therapeutic options

JC Szepietowski et al.

THERAPEUTIC APHERESIS AND DIALYSIS (2005)

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Article Anesthesiology

CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain

N Clayton et al.

PAIN (2002)

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Article Dermatology

Adjuvant botulinum toxin A in dyshidrotic hand eczema: a controlled prospective pilot study with left-right comparison

U Wollina et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2002)

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Article Dermatology

The neurosensory tachykinins substance P and neurokinin A directly induce keratinocyte nerve growth factor

GJ Burbach et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2001)

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Article Immunology

OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells

PR Rogers et al.

IMMUNITY (2001)

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Article Biochemistry & Molecular Biology

Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

M Steinhoff et al.

NATURE MEDICINE (2000)

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