4.7 Article

Aquaporin 11 alleviates retinal Muller intracellular edema through water efflux in diabetic retinopathy

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Summary: The study investigated the expression of AQP1, AQP4, and AQP11 in mouse models with acute hyponatremia and hypernatremia. Results showed that acute hyponatremia enhanced AQP4 expression in KO mice, while acute hypernatremia increased AQP4 but decreased AQP1 expression by half in KO mice. AQP4 plays a key role in brain edema regulation at the blood-brain barrier, suggesting that AQP11 may also be involved in osmotic regulation in the brain.

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