☆ 4.4 Review

Platelets in COVID-19 disease: friend, foe, or both?

PHARMACOLOGICAL REPORTS (2022)

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Article Hematology

Platelet Activation and Thrombosis in COVID-19

Toshiaki Iba et al.

Summary: COVID-19-associated coagulopathy has unique characteristics compared to bacterial sepsis, including minimal changes in platelet counts, normal prothrombin times, and increased D-dimer and fibrinogen levels. The pathophysiology of COVID-19-related coagulopathy involves platelet activation driving inflammation and thrombosis, with von Willebrand factor and platelet factor 4 playing important roles.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2023)

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Review Medicine, Research & Experimental

High levels of Von Willebrand factor markers in COVID-19: a systematic review and meta-analysis

Mehrdad Rostami et al.

Summary: Elevated levels of VWF, ADAMTS-13, and factor VIII in COVID-19 patients, especially in ICU patients. These findings suggest that these markers may have prognostic value in assessing the severity of COVID-19. New therapeutic programs can be developed accordingly.

CLINICAL AND EXPERIMENTAL MEDICINE (2022)

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Article Medicine, General & Internal

Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19 A Randomized Clinical Trial

Jeffrey S. Berger et al.

Summary: Adding a P2Y12 inhibitor to anticoagulant therapy did not result in improved organ support-free days in non-critically ill COVID-19 patients hospitalized for COVID-19.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Editorial Material Medicine, General & Internal

Antiplatelet Therapy in Patients With COVID-19-More Is Less?

Bart Spaetgens et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Article Hematology

Unconventional CD147-dependent platelet activation elicited by SARS-CoV-2 in COVID-19

Norma Maugeri et al.

Summary: The study found that COVID-19 patients have activated platelets at admission, characterized by expression and distribution of HMGB1 and von Willebrand factor, accumulation of platelet-derived extracellular vesicles and HMGB1(+) plt-EVs in plasma. Platelets interacting with SARS-CoV-2 in vitro underwent activation, suggesting a potential role of platelet activation in the inflammatory and hemostatic manifestations of COVID-19.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)

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Article Cardiac & Cardiovascular Systems

Cellular and molecular mechanisms in COVID-19 coagulopathy: role of inflammation and endotheliopathy

Rossella Cacciola et al.

Summary: The study found that moderate COVID-19 patients have significantly elevated levels of inflammation, endothelial and coagulation molecules, indicating severe abnormalities in coagulation function. Compared to mild patients, moderate COVID-19 patients have significantly shortened clotting time, decreased clot formation time, and enhanced clotting activity. Therefore, attention should be paid to coagulopathy in COVID-19, closely monitoring coagulation status and appropriately applying anticoagulants may help improve the prognosis of moderate patients and prevent disease progression.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2022)

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Article Medicine, General & Internal

Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19 A Randomized Clinical Trial

Charlotte A. Bradbury et al.

Summary: The study results showed that among critically ill patients with COVID-19, treatment with an antiplatelet agent compared with no antiplatelet agent did not significantly improve the number of organ support-free days within 21 days. The use of antiplatelet therapy in critically ill patients with COVID-19 did not show significant benefits.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Article Cardiac & Cardiovascular Systems

The roles of platelets in COVID-19-associated coagulopathy and vaccine-induced immune thrombotic thrombocytopenia

Toshiaki Iba et al.

Summary: In COVID-19, multiple thromboinflammatory events contribute to the pathophysiology, including activation of the coagulation system, the essential role of platelets in the disease, and the prothrombotic pathways initiated by the spike protein.

TRENDS IN CARDIOVASCULAR MEDICINE (2022)

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Article Pharmacology & Pharmacy

Direct Thrombin Inhibitor Dabigatran Compromises Pulmonary Endothelial Integrity in a Murine Model of Breast Cancer Metastasis to the Lungs; the Role of Platelets and Inflammation-Associated Haemostasis

Marta Smeda et al.

Summary: This study demonstrates that anticoagulant therapy may promote metastasis of breast cancer, as dabigatran reduces the protection of the pulmonary endothelial barrier and thereby increases the occurrence of pulmonary metastasis.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Hematology

ISTH guidelines for antithrombotic treatment in COVID-19

Sam Schulman et al.

Summary: Antithrombotic agents, particularly heparins, are recommended for patients with COVID-19 to reduce thromboembolism risk. The optimal dosing and timing of these treatments, as well as the benefits of other antithrombotic agents, are still unclear. A panel of experts developed 12 recommendations based on high- to moderate-quality evidence, including the use of prophylactic or therapeutic dose heparin for different patient groups. Additional weak recommendations were made for the use of sulodexide, adding antiplatelet agents, and prophylactic rivaroxaban in select patients. Future updates will incorporate new evidence and may modify these recommendations.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)

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Article Cardiac & Cardiovascular Systems

Aspirin Therapy on Prophylactic Anticoagulation for Patients Hospitalized With COVID-19: A Propensity Score-Matched Cohort Analysis of the HOPE-COVID-19 Registry

Francesco Santoro et al.

Summary: This study evaluates the safety and efficacy of adding aspirin to prophylactic anticoagulation therapy for patients hospitalized with COVID-19. The results demonstrate that combination therapy of prophylactic anticoagulation and aspirin is associated with lower in-hospital mortality risk compared to prophylactic anticoagulation alone.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2022)

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Article Pediatrics

Platelets are indispensable for alveolar development in neonatal mice

Zilu Huang et al.

Summary: This study reveals the significant role of platelets in normal postnatal lung development and the progression of BPD after premature birth, possibly by maintaining endothelial function.

FRONTIERS IN PEDIATRICS (2022)

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Review Cell Biology

Platelets at the Crossroads of Pro-Inflammatory and Resolution Pathways during Inflammation

Nadine Ludwig et al.

Summary: Given the role of platelets in immune modulation, they play a significant role in the acute inflammatory process.

CELLS (2022)

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Article Cardiac & Cardiovascular Systems

A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction

Sunil Rao et al.

Summary: This study investigated the pharmacodynamics, safety, and efficacy of the oral FXIa inhibitor asundexian for secondary prevention after acute myocardial infarction (MI). The results showed that asundexian effectively inhibited coagulation activity without increasing the risk of bleeding or ischemic events.

CIRCULATION (2022)

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Review Medicine, General & Internal

Antiplatelet therapy for patients with COVID-19: Systematic review and meta-analysis of observational studies and randomized controlled trials

Xiaolong Zong et al.

Summary: This study conducted a systematic review and meta-analysis to assess the efficacy of antiplatelet therapy for the treatment of COVID-19. The results showed that antiplatelet treatment may reduce the risk of mortality in COVID-19 patients, but the evidence from randomized controlled trials did not support the use of antiplatelet therapy in standard care.

FRONTIERS IN MEDICINE (2022)

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Review Medicine, General & Internal

Anticoagulants for people hospitalised with COVID-19

Ronald L. G. Flumignan et al.

Summary: COVID-19 patients often develop respiratory insufficiency and may experience pulmonary microthrombosis and thromboembolic events. The use of anticoagulants can prevent and treat these thrombotic issues, but their benefits are still under debate.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2022)

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Review Hematology

Thrombosis in COVID-19 infection: Role of platelet activation-mediated immunity

Mahin Behzadi Fard et al.

Summary: Thrombosis plays a significant role in COVID-19 complications, with platelet activation potentially contributing to vascular and coronary thrombosis. Toll-like receptors (TLRs) are crucial in platelet activation and are essential components in innate immunity response. Therapeutic use of TLR antagonists and monoclonal antibodies against P-selectin may provide advancements in combating thrombosis related complications in COVID-19.

THROMBOSIS JOURNAL (2021)

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Review Medical Laboratory Technology

Thrombocytopenia Is Associated with COVID-19 Severity and Outcome: An Updated Meta-Analysis of 5637 Patients with Multiple Outcomes

Xiaolong Zong et al.

Summary: Approximately 12% of hospitalized COVID-19 patients have thrombocytopenia (TCP), which is associated with more severe illness and poor outcomes. Patients with TCP are at a higher risk of progressing to acute respiratory distress syndrome and mortality, with the risk increased threefold.

LABORATORY MEDICINE (2021)

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Review Hematology

Platelet Proteomes, Pathways, and Phenotypes as Informants of Vascular Wellness and Disease

Joseph E. Aslan

Summary: Platelets rapidly change in form and function to repair vascular damage, but in chronic inflammatory conditions, diverse platelet subpopulations with various activated or inhibited phenotypes emerge, potentially indicating disease. The origins and significance of these platelet phenotypic variations remain unclear. Understanding the protein-level relationships of platelets in inflammation, immune response, and aging may help define platelet phenotypes.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

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Article Cell Biology

P2Y12 antagonism results in altered interactions between platelets and regulatory T cells during sepsis

Samara Albayati et al.

Summary: Blocking the P2Y(12) signaling pathway restrains Treg proliferation in both in vivo and in vitro conditions, suggesting a promising strategy for treating sepsis by targeting platelet-mediated Treg activity.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

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Review Geriatrics & Gerontology

Aging & COVID-19 susceptibility, disease severity, and clinical outcomes: The role of entangled risk factors

Melina Farshbafnadi et al.

Summary: The elderly population is at a higher risk of severe impacts from COVID-19 due to factors such as increased ACE-2 expression, immune dysregulation, decreased sex hormones, oxidative stress, and comorbidities like cardiovascular diseases and diabetes mellitus. These factors contribute to the higher mortality and morbidity rates observed in older adults infected with SARS-CoV-2.

EXPERIMENTAL GERONTOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

Sean X. Gu et al.

Summary: Platelet and endothelial dysfunction are essential components of COVID-19 pathology, while cardiovascular risk factors exacerbate the severity of the disease. Patients with pre-existing cardiovascular disease and risk factors are at the highest risk of death from COVID-19.

NATURE REVIEWS CARDIOLOGY (2021)

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Review Hematology

Platelets and COVID-19

Anne-Katrin Rohlfing et al.

HAMOSTASEOLOGIE (2021)

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Review Biochemistry & Molecular Biology

Prothrombotic Phenotype in COVID-19: Focus on Platelets

Cristina Barale et al.

Summary: COVID-19 infection is associated with a range of symptoms, with alveolar capillary microthrombi being a common finding, likely due to severe endothelial injury. This suggests a COVID-19-related coagulopathy may worsen thrombosis, organ damage, severity, and mortality.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, General & Internal

Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19 The ACTIV-4B Randomized Clinical Trial

Jean M. Connors et al.

Summary: This study aimed to assess the impact of anticoagulant or antiplatelet therapy on symptomatic clinically stable outpatients with COVID-19. The results showed that treatment with aspirin or apixaban compared with placebo did not reduce the rate of a composite clinical outcome, and the study was terminated early due to a lower than anticipated event rate.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Cell Biology

Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection

Giuseppe Cappellano et al.

Summary: This study evaluated the diagnostic performance of circulating platelets-derived extracellular vesicles as biomarkers for Sars-Cov-2 infection, suggesting that PLT-EVs might be an interesting biomarker deserving further investigations to test their predictive power.

CELLS (2021)

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Editorial Material Hematology

Platelets maintain vascular barrier function in the absence of injury or inflammation

Benoit Ho-Tin-Noe et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Biochemistry & Molecular Biology

COVID-19 induces a hyperactive phenotype in circulating platelets

Shane P. Comer et al.

Summary: This study found distinct differences in routine full blood count and other clinical laboratory parameters between patients with severe and nonsevere COVID-19. It also determined that all COVID-19 patients possess hyperactive circulating platelets, suggesting abnormal platelet reactivity may contribute to hypercoagulability in COVID-19, influencing the severity of the disease and recovery path complexity.

PLOS BIOLOGY (2021)

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Review Medicine, General & Internal

Thrombocytopenia in Virus Infections

Matthijs Raadsen et al.

Summary: Thrombocytopenia, a common finding in viral infections, is often associated with signs of an infectious disease. Different mechanisms and roles of platelets in viral infections are being explored in current literature.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Circulating Exosomes Are Strongly Involved in SARS-CoV-2 Infection

Elettra Barberis et al.

Summary: Limited knowledge of the host response to SARS-CoV-2 hinders understanding of COVID-19 pathogenesis and therapeutic strategies. This study revealed that SARS-CoV-2 infection modulates exosome content and their involvement in disease progression, highlighting the potential of plasma exosomes as biomarkers for disease severity. Proteomic analysis of patient-derived exosomes identified molecules implicated in immune response, inflammation, coagulation, and complement pathways associated with COVID-19 tissue damage and organ dysfunction. Moreover, the presence of SARS-CoV-2 RNA in exosomes suggests a potential route for viral spread.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Hematology

Dissemination of extreme levels of extracellular vesicles: tissue factor activity in patients with severe COVID-19

Christophe Guervilly et al.

Summary: The study found that EV-TF activity is notably increased in severe COVID-19 patients compared to moderate cases, and is associated with inflammation, disease severity, and thrombotic risk. Patients with severe COVID-19 exhibited a distinct coagulopathy profile with high EV-TF and EV-fibrinolytic activities. These findings support the need for preventive anticoagulation in hospitalized COVID-19 patients.

BLOOD ADVANCES (2021)

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Letter Respiratory System

Between inflammation and thrombosis: endothelial cells in COVID-19

Anna Birnhuber et al.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Review Hematology

Platelets: 'multiple choice' effectors in the immune response and their implication in COVID-19 thromboinflammatory process

Roberta Rolla et al.

Summary: Platelets play a role in both innate and adaptive immune responses, beyond just their traditional function in hemostasis. Their interactions with hemostasis, inflammation, and the immune response are multifaceted, amplifying body defense processes but also potentially leading to life-threatening pathological processes.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2021)

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Review Biochemistry & Molecular Biology

Blood Platelets as an Important but Underrated Circulating Source of TGFβ

Kamil Karolczak et al.

Summary: Platelets are key regulators of TGF beta levels, but there is limited research on developing platelet-directed therapies; however, promising reports suggest that platelet TGF beta may play specific roles in cardiovascular diseases, liver fibrosis, tumor metastasis, cerebral malaria, and inflammatory cell function regulation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Medical Laboratory Technology

Update on endothelial dysfunction in COVID-19: severe disease, long COVID-19 and pediatric characteristics

Eleni Gavriilaki et al.

Summary: Emerging evidence suggests that endothelial dysfunction may play a role in severe COVID-19 in both adults and children, as well as in cases of long COVID-19, indicating shared pathophysiological pathways. This narrative review provides a comprehensive summary of the current knowledge on endothelial dysfunction caused by COVID-19, including new insights into long COVID-19 and pediatric cases. Understanding these aspects is crucial not only for comprehending the multi-systemic impact of COVID-19, but also for enhancing patient care and outcomes.

JOURNAL OF LABORATORY MEDICINE (2021)

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Review Cardiac & Cardiovascular Systems

Interplay between inflammation and thrombosis in cardiovascular pathology

Konstantin Stark et al.

Summary: Thrombosis is a major health challenge globally, with inflammation playing a crucial role in driving thrombotic diseases. Anti-inflammatory strategies show promise in targeting cardiovascular pathologies and addressing therapeutic gaps.

NATURE REVIEWS CARDIOLOGY (2021)

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Review Microbiology

Modulation of Hemostasis in COVID-19; Blood Platelets May Be Important Pieces in the COVID-19 Puzzle

Magdalena Ulanowska et al.

Summary: COVID-19, caused by SARS-CoV-2 virus, affects respiratory function and disrupts the coagulation system, leading to clotting and thrombotic events. Inflammation and cytokine storms are major causes of hemostasis disorders, with the use of anticoagulants such as heparin recommended to prevent and treat thrombosis. The relationship between blood platelets and COVID-19, as well as the potential use of antiplatelet drugs in COVID-19 cases, are also areas of focus in research.

PATHOGENS (2021)

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Article Immunology

Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education

Jan Rossaint et al.

Summary: Platelets play a crucial role in immune cell recruitment and host defense in addition to hemostasis. They form aggregates with regulatory T cells in the lung during inflammation, facilitating the release of anti-inflammatory mediators and reprogramming of macrophages for an effective resolution of pulmonary inflammation.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Medicine, Research & Experimental

Soluble P-selectin as a potential diagnostic and prognostic biomarker for COVID-19 disease: A case-control study

Emre Karsli et al.

Summary: This study demonstrates that sP-Selectin can serve as a valuable biomarker for diagnosing and predicting the need for intensive care treatment in COVID-19 infections.

LIFE SCIENCES (2021)

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Article Multidisciplinary Sciences

Platelets amplify endotheliopathy in COVID-19

Tessa J. Barrett et al.

Summary: The study reveals an inflammatory hypercoagulable state between platelets and endothelial cells in COVID-19, with platelet-released factors promoting endotheliopathy. S100A8, S100A9, and their protein product MRP8/14 are enriched in COVID-19 platelets and contribute significantly to poor clinical outcomes. Targeting platelet P2Y(12) appears to be a promising strategy for reducing proinflammatory platelet-endothelial interactions in COVID-19.

SCIENCE ADVANCES (2021)

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Article Biochemistry & Molecular Biology

Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks

Louisa Ruhl et al.

Summary: The study investigated the immune response in severe COVID-19 patients during acute phase and in convalescent patients, revealing a highly inflammatory microenvironment and endothelial injury in severe cases.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Cell Biology

C-type lectins and extracellular vesicles in virus-induced NETosis

Pei-Shan Sung et al.

Summary: Dysregulated formation of neutrophil extracellular traps (NETs) is observed in acute viral infections, with excessive NET formation associated with disease severity, and related to dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and other members of C-type lectin family.

JOURNAL OF BIOMEDICAL SCIENCE (2021)

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Article Immunology

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

Aldo Bonaventura et al.

Summary: The authors suggest that SARS-CoV-2 infection induces a prothrombotic state and dysregulated immunothrombosis, leading to severe manifestations of COVID-19. They also discuss potential antithrombotic and immunomodulating drugs for treating COVID-19 patients, aiming to reduce the acute and long-term consequences of the disease by targeting immunothrombosis.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies

Andreas Daiber et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Article Peripheral Vascular Disease

Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients

David M. Smadja et al.

ANGIOGENESIS (2020)

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Article Hematology

Platelets docking to VWF prevent leaks during leukocyte extravasation by stimulating Tie-2

Laura J. Braun et al.

BLOOD (2020)

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Article Cell Biology

Platelet functions and activities as potential hematologic parameters related to Coronavirus Disease 2019 (Covid-19)

Francesca Salamanna et al.

PLATELETS (2020)

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Letter Medicine, General & Internal

Endothelial cell infection and endotheliitis in COVID-19

Zsuzsanna Varga et al.

LANCET (2020)

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Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Cardiac & Cardiovascular Systems

Loss of Protease-Activated Receptor 4 Prevents Inflammation Resolution and Predisposes the Heart to Cardiac Rupture After Myocardial Infarction

Mikhail A. Kolpakov et al.

CIRCULATION (2020)

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Article Hematology

Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome

Elizabeth A. Middleton et al.

BLOOD (2020)

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Article Hematology

Platelet gene expression and function in patients with COVID-19

Bhanu Kanth Manne et al.

BLOOD (2020)

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Editorial Material Cardiac & Cardiovascular Systems

Endothelial barrier integrity in COVID-19-dependent hyperinflammation: does the protective facet of platelet function matter?

Marta Smeda et al.

CARDIOVASCULAR RESEARCH (2020)

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Article Medicine, General & Internal

Vascular occlusion by neutrophil extracellular traps in COVID-19

Moritz Leppkes et al.

EBIOMEDICINE (2020)

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Review Oncology

Role of platelet biomarkers in inflammatory response

Yufei Chen et al.

BIOMARKER RESEARCH (2020)

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Article Hematology

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19

Eugenio D. Hottz et al.

BLOOD (2020)

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Article Cardiac & Cardiovascular Systems

Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19

Younes Zaid et al.

CIRCULATION RESEARCH (2020)

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Editorial Material Cardiac & Cardiovascular Systems

COVID-19 is, in the end, an endothelial disease

Peter Libby et al.

EUROPEAN HEART JOURNAL (2020)

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Article Hematology

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

F. A. Klok et al.

THROMBOSIS RESEARCH (2020)

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Article Hematology

COVID-19 and Venous Thromboembolism: A Meta-analysis of Literature Studies

Alessandro Di Minno et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2020)

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Review Hematology

The Immune Nature of Platelets Revisited

Amal Maouia et al.

TRANSFUSION MEDICINE REVIEWS (2020)

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Article Multidisciplinary Sciences

Mode of induction of platelet-derived extracellular vesicles is a critical determinant of their phenotype and function

P. M. Ferreira et al.

SCIENTIFIC REPORTS (2020)

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Article Hematology

Platelets function as an acute viral reservoir during HIV-1 infection by harboring virus and T-cell complex formation

Sydney R. Simpson et al.

BLOOD ADVANCES (2020)

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Editorial Material Cardiac & Cardiovascular Systems

Platelets and COVID-19 Inflammation, Hyperactivation and Additional Questions

Milka Koupenova et al.

CIRCULATION RESEARCH (2020)

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Article Multidisciplinary Sciences

Vascular surveillance by haptotactic blood platelets in inflammation and infection

Leo Nicolai et al.

NATURE COMMUNICATIONS (2020)

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Article Cardiac & Cardiovascular Systems

Degradation of Glycocalyx and Multiple Manifestations of Endothelial Dysfunction Coincide in the Early Phase of Endothelial Dysfunction Before Atherosclerotic Plaque Development in Apolipoprotein E/Low-Density Lipoprotein Receptor-Deficient Mice

Anna Bar et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2019)

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Article Multidisciplinary Sciences

The role of platelets in mediating a response to human influenza infection

Milka Koupenova et al.

NATURE COMMUNICATIONS (2019)

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Article Cardiac & Cardiovascular Systems

Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation

Elena Y. Senchenkova et al.

CIRCULATION (2019)

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Article Cardiac & Cardiovascular Systems

Combination Antiplatelet and Oral Anticoagulant Therapy in Patients With Coronary and Peripheral Artery Disease Focus on the COMPASS Trial

Paul A. Gurbel et al.

CIRCULATION (2019)

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Article Cell Biology

Detection of tissue factor in platelets: why is it so troublesome?

Bjarne Osterud et al.

PLATELETS (2019)

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Article Multidisciplinary Sciences

Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation

Xiaoli Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Hematology

Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin

Katsue Suzuki-Inoue

BLOOD (2019)

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Review Immunology

Platelets in Inflammation and Resolution

Andreas Margraf et al.

JOURNAL OF IMMUNOLOGY (2019)

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Review Cardiac & Cardiovascular Systems

Platelet biology and functions: new concepts and clinical perspectives

Paola E. J. van der Meijden et al.

NATURE REVIEWS CARDIOLOGY (2019)

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Review Gastroenterology & Hepatology

Platelets and Platelet-Derived Extracellular Vesicles in Liver Physiology and Disease

Alexandre Balaphas et al.

HEPATOLOGY COMMUNICATIONS (2019)

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Article Hematology

Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury

William Bain et al.

BLOOD ADVANCES (2019)

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Article Biochemistry & Molecular Biology

CLEC-2-Induced Signaling in Blood Platelets

A. A. Martyanov et al.

BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY (2019)

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Review Biochemistry & Molecular Biology

Amicus or Adversary Revisited: Platelets in Acute Lung Injury and Acute Respiratory Distress Syndrome

Elizabeth A. Middleton et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)

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Review Biochemical Research Methods

Understanding extracellular vesicle diversity - current status

David W. Greening et al.

EXPERT REVIEW OF PROTEOMICS (2018)

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Article Immunology

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution

Jonathan D. Proto et al.

IMMUNITY (2018)

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Review Immunology

Role of Platelets in Leukocyte Recruitment and Resolution of Inflammation

Jan Rossaint et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Medicine, General & Internal

Platelets in Immune Response to Virus and Immunopathology of Viral Infections

Eugenio D. Hottz et al.

FRONTIERS IN MEDICINE (2018)

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Article Hematology

Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice

Hui Zhou et al.

BLOOD ADVANCES (2018)

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Review Hematology

Platelets and vascular integrity: how platelets prevent bleeding in inflammation

Benoit Ho-Tin-Noe et al.

BLOOD (2018)

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Article Immunology

Platelets Mediate Host Defense against Staphylococcus aureus through Direct Bactericidal Activity and by Enhancing Macrophage Activities

Ramadan A. Ali et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Cell Biology

Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PGE2 and Cytokines

Bona Linke et al.

MEDIATORS OF INFLAMMATION (2017)

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Article Multidisciplinary Sciences

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

Emma Lefrancais et al.

NATURE (2017)

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Article Hematology

Thrombin-activated platelet-derived exosomes regulate endothelial cell expression of ICAM-1 via microRNA-223 during the thrombosis-inflammation response

Jiannan Li et al.

THROMBOSIS RESEARCH (2017)

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Review Virology

Myeloid C-Type Lectin Receptors in Viral Recognition and Antiviral Immunity

Joao T. Monteiro et al.

VIRUSES-BASEL (2017)

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Article Multidisciplinary Sciences

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

Julie Rayes et al.

NATURE COMMUNICATIONS (2017)

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Article Cell Biology

Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact

Kazuhiro Takara et al.

CELL REPORTS (2017)

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Article Microbiology

Signaling C-type lectin receptors in antimycobacterial immunity

Mohlopheni J. Marakalala et al.

PLOS PATHOGENS (2017)

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Article Multidisciplinary Sciences

Platelets protect lung from injury induced by systemic inflammatory response

Shuhua Luo et al.

SCIENTIFIC REPORTS (2017)

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Review Microbiology

C-type lectin receptors in anti-fungal immunity

Moe Shiokawa et al.

CURRENT OPINION IN MICROBIOLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Differential eNOS-signalling by platelet subpopulations regulates adhesion and aggregation

Aneta Radziwon-Balicka et al.

CARDIOVASCULAR RESEARCH (2017)

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Article Physiology

Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse

Sian Lax et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2017)

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Article Cell Biology

Mediators and molecular pathways involved in the regulation of neutrophil extracellular trap formation mediated by activated platelets

Agostina Carestia et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2016)

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Review Hematology

Platelet immunoreceptor tyrosine-based activation motif (ITAM) and hemITAM signaling and vascular integrity in inflammation and development

R. H. Lee et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2016)

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Review Biotechnology & Applied Microbiology

Resolution of inflammation: a new therapeutic frontier

James N. Fullerton et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

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Review Physiology

PLATELETS IN PULMONARY IMMUNE RESPONSES AND INFLAMMATORY LUNG DISEASES

Elizabeth A. Middleton et al.

PHYSIOLOGICAL REVIEWS (2016)

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Article Hematology

The Role of Platelets in Venous Thromboembolism

Silvia Montoro-Garcia et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2016)

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Article Biochemistry & Molecular Biology

Platelets Guide Leukocytes to Their Sites of Extravasation

Gabriele Zuchtriegel et al.

PLOS BIOLOGY (2016)

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Review Immunology

Intercellular Interactions as Regulators of NETosis

Nayef M. Kazzaz et al.

FRONTIERS IN IMMUNOLOGY (2016)

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Review Immunology

Resolution of inflammation: what Controls its Onset?

Michelle A. Sugimoto et al.

FRONTIERS IN IMMUNOLOGY (2016)

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Article Physiology

Anticoagulation increases alveolar hemorrhage in mice infected with influenza A

Kohei Tatsumi et al.

PHYSIOLOGICAL REPORTS (2016)

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Article Critical Care Medicine

Platelet Activation and Aggregation Promote Lung Inflammation and Influenza Virus Pathogenesis

Vuong Ba Le et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

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Review Immunology

Human platelets and their capacity of binding viruses: meaning and challenges?

Adrien Chabert et al.

BMC IMMUNOLOGY (2015)

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Review Hematology

The diversity of platelet microparticles

Eric Boilard et al.

CURRENT OPINION IN HEMATOLOGY (2015)

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Article Medicine, Research & Experimental

Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage

Issaka Yougbare et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

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Review Immunology

Nouvelle Cuisine: Platelets Served with Inflammation

Rick Kapur et al.

JOURNAL OF IMMUNOLOGY (2015)

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Article Hematology

Expression and functionality of Toll-like receptor3 in the megakaryocytic lineage

L. P. D'Atri et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2015)

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Review Immunology

Are platelets cells? And if yes, are they immune cells?

Olivier Garraud et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Review Medicine, Research & Experimental

Platelets in hemostasis and thrombosis: Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis

Yan Hou et al.

JOURNAL OF BIOMEDICAL RESEARCH (2015)

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Article Hematology

Influenza virus H1N1 activates platelets through FcγRIIA signaling and thrombin generation

Eric Boilard et al.

BLOOD (2014)

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Article Hematology

Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis

Milka Koupenova et al.

BLOOD (2014)

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Article Multidisciplinary Sciences

Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective

Raja-Elie E. Abdulnour et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Review Physiology

Platelets in Lung Biology

Andrew S. Weyrich et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 (2013)

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Article Hematology

Platelets support a protective immune response to LCMV by preventing splenic necrosis

Gilbert David Loria et al.

BLOOD (2013)

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Article Hematology

Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation

Eugenio D. Hottz et al.

BLOOD (2013)

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Article Medicine, Research & Experimental

PAR-1 contributes to the innate immune response during viral infection

Silvio Antoniak et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

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Article Immunology

Activated Platelets Enhance IL-10 Secretion and Reduce TNF-α Secretion by Monocytes

Sif Gudbrandsdottir et al.

JOURNAL OF IMMUNOLOGY (2013)

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Review Hematology

Platelet receptors activated via mulitmerization: glycoprotein VI, GPIb-IX-V, and CLEC-2

Y. Ozaki et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2013)

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Article Immunology

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance

Connie H. Y. Wong et al.

NATURE IMMUNOLOGY (2013)

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Review Physiology

NEW FUNDAMENTALS IN HEMOSTASIS

Henri H. Versteeg et al.

PHYSIOLOGICAL REVIEWS (2013)

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Review Immunology

Graft rejection - endogenous or allogeneic?

William R. Critchley et al.

IMMUNOLOGY (2012)

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Article Cell Biology

T granules in human platelets function in TLR9 organization and signaling

Jonathan N. Thon et al.

JOURNAL OF CELL BIOLOGY (2012)

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Article Immunology

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

Marie-Luise von Bruehl et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

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Article Multidisciplinary Sciences

Platelet Factor 4 and Duffy Antigen Required for Platelet Killing of Plasmodium falciparum

Brendan J. McMorran et al.

SCIENCE (2012)

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Review Hematology

Platelets at work in primary hemostasis

Katleen Broos et al.

BLOOD REVIEWS (2011)

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Article Immunology

Lipopolysaccharide Signaling without a Nucleus: Kinase Cascades Stimulate Platelet Shedding of Proinflammatory IL-1β-Rich Microparticles

G. Thomas Brown et al.

JOURNAL OF IMMUNOLOGY (2011)

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Review Hematology

Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation

D. Cox et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2011)

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Review Hematology

Novel platelet activation receptor CLEC-2: from discovery to prospects

K. Suzuki-Inoue et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2011)

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Article Microbiology

Novel Anti-bacterial Activities of β-defensin 1 in Human Platelets: Suppression of Pathogen Growth and Signaling of Neutrophil Extracellular Trap Formation

Bjoern F. Kraemer et al.

PLOS PATHOGENS (2011)

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Article Hematology

P-Selectin-Mediated Platelet-Neutrophil Aggregate Formation Activates Neutrophils in Mouse and Human Sickle Cell Disease

Renata Polanowska-Grabowska et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)

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Article Immunology

Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums

Kodi S. Ravichandran

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

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Article Virology

Pathogenic Hantaviruses Direct the Adherence of Quiescent Platelets to Infected Endothelial Cells

Irina N. Gavrilovskaya et al.

JOURNAL OF VIROLOGY (2010)

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Review Hematology

Effect of antiplatelet therapy on inflammatory markers in atherothrombotic patients

Joseph B. Muhlestein

THROMBOSIS AND HAEMOSTASIS (2010)

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Article Surgery

Platelet-Derived CD40L (CD154) Mediates Neutrophil Upregulation of Mac-1 and Recruitment in Septic Lung Injury

Milladur Rahman et al.

ANNALS OF SURGERY (2009)

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Article Hematology

Inflammation induces hemorrhage in thrombocytopenia

Tobias Goerge et al.

BLOOD (2008)

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Article Biochemistry & Molecular Biology

Platelets augment respiratory burst in neutrophils activated by selected species of gram-positive or gram-negative bacteria

Jacek Miedzobrodzki et al.

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA (2008)

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Review Medicine, General & Internal

Platelets, petechiae, and preservation of the vascular wall

Ralph L. Nachman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Review Medicine, General & Internal

Mechanisms of disease:: Platelet activation and atherothrombosis

Giovanni Davi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

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Review Immunology

Platelet integrins and immunoreceptors

Ana Kasirer-Friede et al.

IMMUNOLOGICAL REVIEWS (2007)

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Article Biochemistry & Molecular Biology

Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood

Stephen R. Clark et al.

NATURE MEDICINE (2007)

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Article Cell Biology

Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation

BD Elzey et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2005)

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Article Ophthalmology

LPA and S1P increase corneal epithelial and endothelial cell transcellular resistance

F Yin et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2005)

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Article Hematology

Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions

JA Coppinger et al.

BLOOD (2004)

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Article Immunology

Platelet-mediated modulation of adaptive immunity: A communication link between innate and adaptive immune compartments

BD Elzey et al.

IMMUNITY (2003)

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Article Hematology

Obligatory role of lipid mediators in platelet-neutrophil adhesion

S Chlopicki et al.

THROMBOSIS RESEARCH (2003)

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Article Physiology

Platelet lipid(s) bound to albumin increases endothelial electrical resistance: mimicked by LPA

FL Minnear et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2001)

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Article Cardiac & Cardiovascular Systems

RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium

P von Hundelshausen et al.

CIRCULATION (2001)

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Article Biochemistry & Molecular Biology

Thrombocidins, microbicidal proteins from human flood platelets, are C-terminal deletion products of CXC chemokines

J Krijgsveld et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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