☆ 4.5 Article

An Analytical Solution for Saturable Absorption in Pharmacokinetics Models

PHARMACEUTICAL RESEARCH (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Pharmacology & Pharmacy

Prediction of Maternal and Fetoplacental Concentrations of Cefazolin, Cefuroxime, and Amoxicillin during Pregnancy Using Bottom-Up Physiologically Based Pharmacokinetic Models

Khaled Abduljalil et al.

Summary: This study developed a PBPK model to predict the disposition of certain drugs in maternal and fetal tissues. The model accurately predicted the exposure levels in both the mother and fetus, and could be used for clinical trial design and risk assessment for maternal-fetal exposure.

DRUG METABOLISM AND DISPOSITION (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Re-writing Oral Pharmacokinetics Using Physiologically Based Finite Time Pharmacokinetic (PBFTPK) Models

Pavlos Chryssafidis et al.

Summary: The purpose of this study was to develop physiologically based finite time pharmacokinetic models for the analysis of oral pharmacokinetic data. The models were based on the passive drug diffusion mechanism under the sink conditions principle. Simulated data and experimental literature data were used to validate the models. The results showed that the PBFTPK models are a powerful tool for analyzing oral pharmacokinetic data.

PHARMACEUTICAL RESEARCH (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Columbus' egg: Oral drugs are absorbed in finite time

P. Macheras et al.

Summary: The assumption of infinite time for oral drug absorption has had a significant impact on the study of bioavailability and bioequivalence. However, it has been revealed that drug absorption has a finite time period, calling for regulatory changes in assessment methods.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Re-examining digoxin bioavailability after half a century: Time for changes in the bioavailability concepts

Athanasios A. Tsekouras et al.

PHARMACEUTICAL RESEARCH (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Signal Processing Approach to Pharmacokinetic Data Analysis

C. O. S. Sorzano et al.

Summary: This article examines the connection between pharmacokinetic models and system theory, demonstrating how system theory can easily accommodate different therapeutic regimes and identify pharmacokinetic parameters through non-linear regression analysis. It also explores using the properties of linear systems to identify non-linearities in the data, as well as the use of bootstrapping to compare parameter populations and handle multiple hypothesis tests. Finally, it shows how bootstrap values can estimate the distribution of derived parameters.

PHARMACEUTICAL RESEARCH (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Revising Pharmacokinetics of Oral Drug Absorption: II Bioavailability-Bioequivalence Considerations

Pavlos Chryssafidis et al.

Summary: The study explores the application of PBFTPK models in assessing bioavailability and bioequivalence, developing a methodology for estimating absolute bioavailability exclusively from oral data. Simulated data showed that PBFTPK models are more similar to in vivo conditions, with useful parameters for assessing drug exposure and absorption extent. Estimates for F can be derived from oral data exclusively, with findings close to unity for theophylline formulations.

PHARMACEUTICAL RESEARCH (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug-Drug-Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals

Nina Hanke et al.

CLINICAL PHARMACOKINETICS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Revising Pharmacokinetics of Oral Drug Absorption: I Models Based on Biopharmaceutical/Physiological and Finite Absorption Time Concepts

Panos Macheras et al.

PHARMACEUTICAL RESEARCH (2020)

添加到收藏夹

Editorial Material Chemistry, Multidisciplinary

On an Unphysical Hypothesis of Bateman Equation and its Implications for Pharmacokinetics

Panos Macheras

PHARMACEUTICAL RESEARCH (2019)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Monoclonal antibodies for severe asthma: Pharmacokinetic profiles

Maria Gabriella Matera et al.

RESPIRATORY MEDICINE (2019)

添加到收藏夹

Review Nutrition & Dietetics

The Pharmacokinetics of Vitamin C

Jens Lykkesfeldt et al.

NUTRIENTS (2019)

添加到收藏夹

Article Medicine, General & Internal

Practical guidance for dosing and switching from paliperidone palmitate 1 monthly to 3 monthly formulation in schizophrenia

Srihari Gopal et al.

CURRENT MEDICAL RESEARCH AND OPINION (2015)

添加到收藏夹

Article History & Philosophy Of Science

The Hill equation and the origin of quantitative pharmacology

Rudolf Gesztelyi et al.

ARCHIVE FOR HISTORY OF EXACT SCIENCES (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

Subcutaneous Absorption of Monoclonal Antibodies: Role of Dose, Site of Injection, and Injection Volume on Rituximab Pharmacokinetics in Rats

Leonid Kagan et al.

PHARMACEUTICAL RESEARCH (2012)

添加到收藏夹

Editorial Material Chemistry, Multidisciplinary

The Changing Face of the Rate Concept in Biopharmaceutical Sciences: From Classical to Fractal and Finally to Fractional

Aristides Dokoumetzidis et al.

PHARMACEUTICAL RESEARCH (2011)

添加到收藏夹

Article Pharmacology & Pharmacy

On the use of the Weibull function for the discernment of drug release mechanisms

V Papadopoulou et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2006)

添加到收藏夹

Article Pharmacology & Pharmacy

Pharmacokinetic models for the saturable absorption of cefuroxime axetil and saturable elimination of cefuroxime

P Ruiz-Carretero et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.