期刊
CELL
卷 163, 期 6, 页码 1527-1538出版社
CELL PRESS
DOI: 10.1016/j.cell.2015.10.071
关键词
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资金
- Leibniz Association [PAKT-2006-FLI, SAW-2012-FLI]
- German Research Foundation (DFG) [RE 3505/1-1, HA 6214/2-1, SFB 1074, Z1]
- German Federal Ministry of Education and Research (BMBF) [0315581A/C, 031A099, 0315894A]
- European Community's Seventh Framework Program (FP7) [602783]
- Italian Ministry of Higher Education (FIRB) [RBAP10L8TY]
The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the laboratory. Its rapid growth, early sexual maturation, fast aging, and arrested embryonic development (diapause) make it an attractive model organism in biomedical research. Here, we report a draft sequence of its genome that allowed us to uncover an intra-species Y chromosome polymorphism representing-in real time-different stages of sex chromosome formation that display features of early mammalian XY evolution in action. Our data suggest that gdf6Y, encoding a TGF-beta family growth factor, is the master sex-determining gene in N. furzeri. Moreover, we observed genomic clustering of aging-related genes, identified genes under positive selection, and revealed significant similarities of gene expression profiles between diapause and aging, particularly for genes controlling cell cycle and translation. The annotated genome sequence is provided as an online resource (http://www.nothobranchius.info/NFINgb).
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