期刊
PEPTIDES
卷 163, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2023.170963
关键词
Kisspeptin; Estradiol; Estrogen; Neuropeptide; Reproduction; Neuroendocrine; AVPV; Arcuate; Feedback; HPG axis
Gonadal steroid feedback regulates the secretion of GnRH, with negative feedback modulating the amplitude and frequency of GnRH pulses and positive feedback inducing a surge pattern of GnRH release. Kisspeptin-expressing neurons in the arcuate nucleus and anteroventral periventricular area are thought to mediate these feedback mechanisms and patterns of GnRH secretion.
Gonadal steroid feedback regulates the brain's patterned secretion of gonadotropin-releasing hormone (GnRH). Negative feedback, which occurs in males and during the majority of the female cycle, modulates the amplitude and frequency of GnRH pulses. Positive feedback occurs in females when high estradiol induces a surge pattern of GnRH release. These two forms of feedback and their corresponding patterns of GnRH secretion are thought to be mediated by kisspeptin-expressing neurons in two hypothalamic areas: the arcuate nucleus and the anteroventral periventricular area. In this review, we present evidence for this theory and remaining questions to be addressed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据