4.5 Article

Meningitis Among Neonates with Suspected Sepsis Presenting to Pediatric Emergency

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PEDIATRIC INFECTIOUS DISEASE JOURNAL
卷 42, 期 4, 页码 E124-E127

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LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0000000000003816

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antimicrobial stewardship; cerebrospinal fluid; multidrug resistance; neonate; sepsis

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We conducted a study to evaluate the risk factors, clinical features, and microbial profiles of meningitis in neonates with suspected sepsis. Out of 191 enrolled neonates over a 13-month period, 64 (33.5%) were diagnosed with meningitis. There were no significant differences in risk factors or clinical features between infants with and without meningitis. Culture-positive sepsis was observed in 49% of neonates (109 isolates), with Candida spp., coagulase-negative staphylococci, and Klebsiella pneumoniae being the most commonly identified pathogens. Among these bacteria, 53% were multidrug-resistant.
We aimed to assess the risk factors, clinical features and microbial profiles of meningitis in neonates with suspected sepsis referred to a pediatric emergency. Over 13 months, 191 neonates were enrolled, of whom 64 (33.5%) had meningitis. There were no significant differences in risk factors or clinical features between infants with and without meningitis. Ninety-three neonates (49%) had culture-positive sepsis (109 isolates). Candida spp. (n = 29), coagulase-negative staphylococci (n = 28) and Klebsiella pneumoniae (n = 23) were the most common pathogens. Forty-one (53%) bacteria were multidrug resistant.

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