期刊
PEDIATRIC DERMATOLOGY
卷 40, 期 2, 页码 261-264出版社
WILEY
DOI: 10.1111/pde.15198
关键词
early treatment; infantile hemangioma; propranolol; referral; treatment initiation
Early referral and treatment of infantile hemangioma is challenging, and there is a lack of data on the optimal timing for initiating treatment with oral propranolol. This study found that starting oral propranolol before 10 weeks of age was associated with a significantly higher treatment success rate of 86%, compared to a success rate of 60% when starting treatment after 10 weeks of age.
Background/Objectives: Early referral and treatment of infantile hemangioma (IH) is a major challenge for treatment success. However, there is a lack of data supporting a specific threshold for initiating treatment with oral propranolol. The aim of this analysis was to find factors, such as age at treatment initiation, leading to a higher success rate with oral propranolol treatment.Methods: Based on data from the pivotal phase 2-3 clinical trial of oral propranolol in IH, we used Generalized Additive Model (GAM) charts with Generalized Linear Models (GLM), then a rule discovery algorithm, to identify sub-groups presenting a high probability of occurrence of the predefined outcome (i.e., success [complete or nearly complete resolution of the target hemangioma] at 6 months of treatment).Results: Our analyses identified that patients who started oral propranolol 3 mg/kg/day before the age of 10 weeks had a success rate of 86%, higher than the 60% success rate for all patients that received the same regimen commencing after 10 weeks of age.Conclusions: Treatment initiation before 10 weeks of age was associated with a significantly higher rate of treatment success with oral propranolol 3 mg/kg/day. Infants with IH requiring treatment should be referred to an expert center and treated as soon as possible.
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